Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study
Platelet endothelial aggregation receptor 1 (PEAR1) and prostaglandin endoperoxide synthase 1 (PTGS1) polymorphisms can affect laboratory aspirin resistance. However, the impact of genetic polymorphisms on the recurrence of ischemic stroke (IS) patients treated with aspirin is not fully understood....
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| Veröffentlicht in: | Medicine (Baltimore) Jg. 103; H. 19; S. e38031 |
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10.05.2024
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| Abstract | Platelet endothelial aggregation receptor 1 (PEAR1) and prostaglandin endoperoxide synthase 1 (PTGS1) polymorphisms can affect laboratory aspirin resistance. However, the impact of genetic polymorphisms on the recurrence of ischemic stroke (IS) patients treated with aspirin is not fully understood. This study aimed to examine the relationship between gene polymorphisms of PEAR1 and PTGS1 and IS recurrence in patients treated with aspirin. Peripheral blood samples were collected from 174 patients with nonrecurrent IS and 34 with recurrent IS after aspirin treatment. Follow-up was performed on all patients. PEAR1 rs12041331 and PTGS1 rs10306114 polymorphisms were determined using the PCR fluorescence probe method. And the correlations of them with the clinical characteristics were examined by multivariable logistic regression analysis. The distribution frequencies of PEAR1 rs12041331 and PTGS1 rs10306114 genotypes were in Hardy-Weinberg equilibrium, and there was no significant difference in the distribution of PEAR1 rs12041331 polymorphism. Compared to the nonrecurrent group, the AA genotype of the PTGS1 polymorphism was more frequent in the recurrent group (59.77% vs 35.29%, P = .003), and the A allele also showed a higher frequency than the G allele in the recurrent group (P = .001). Multivariable logistic regression analysis showed that smoking (OR = 5.228, 95% CI: 1.938-14.102, P = .001), coronary heart disease (OR = 4.754, 95% CI: 1.498-15.089, P = .008), and the polymorphism at PTGS1(A>G) AA/AG + GG (OR = 2.955, 95% CI: 1.320-6.616, P = .008) were independently associated with IS recurrence in Chinese patients. Our findings suggested that PTGS rs10306114 polymorphisms should receive more attention in the use of aspirin in patients with IS. |
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| AbstractList | Platelet endothelial aggregation receptor 1 ( PEAR1 ) and prostaglandin endoperoxide synthase 1 ( PTGS1 ) polymorphisms can affect laboratory aspirin resistance. However, the impact of genetic polymorphisms on the recurrence of ischemic stroke (IS) patients treated with aspirin is not fully understood. This study aimed to examine the relationship between gene polymorphisms of PEAR1 and PTGS1 and IS recurrence in patients treated with aspirin. Peripheral blood samples were collected from 174 patients with nonrecurrent IS and 34 with recurrent IS after aspirin treatment. Follow-up was performed on all patients. PEAR1 rs12041331 and PTGS1 rs10306114 polymorphisms were determined using the PCR fluorescence probe method. And the correlations of them with the clinical characteristics were examined by multivariable logistic regression analysis. The distribution frequencies of PEAR1 rs12041331 and PTGS1 rs10306114 genotypes were in Hardy-Weinberg equilibrium, and there was no significant difference in the distribution of PEAR1 rs12041331 polymorphism. Compared to the nonrecurrent group, the AA genotype of the PTGS1 polymorphism was more frequent in the recurrent group (59.77% vs 35.29%, P = .003), and the A allele also showed a higher frequency than the G allele in the recurrent group ( P = .001). Multivariable logistic regression analysis showed that smoking (OR = 5.228, 95% CI: 1.938–14.102, P = .001), coronary heart disease (OR = 4.754, 95% CI: 1.498–15.089, P = .008), and the polymorphism at PTGS1(A>G) AA/AG + GG (OR = 2.955, 95% CI: 1.320–6.616, P = .008) were independently associated with IS recurrence in Chinese patients. Our findings suggested that PTGS rs10306114 polymorphisms should receive more attention in the use of aspirin in patients with IS. Platelet endothelial aggregation receptor 1 (PEAR1) and prostaglandin endoperoxide synthase 1 (PTGS1) polymorphisms can affect laboratory aspirin resistance. However, the impact of genetic polymorphisms on the recurrence of ischemic stroke (IS) patients treated with aspirin is not fully understood. This study aimed to examine the relationship between gene polymorphisms of PEAR1 and PTGS1 and IS recurrence in patients treated with aspirin. Peripheral blood samples were collected from 174 patients with nonrecurrent IS and 34 with recurrent IS after aspirin treatment. Follow-up was performed on all patients. PEAR1 rs12041331 and PTGS1 rs10306114 polymorphisms were determined using the PCR fluorescence probe method. And the correlations of them with the clinical characteristics were examined by multivariable logistic regression analysis. The distribution frequencies of PEAR1 rs12041331 and PTGS1 rs10306114 genotypes were in Hardy-Weinberg equilibrium, and there was no significant difference in the distribution of PEAR1 rs12041331 polymorphism. Compared to the nonrecurrent group, the AA genotype of the PTGS1 polymorphism was more frequent in the recurrent group (59.77% vs 35.29%, P = .003), and the A allele also showed a higher frequency than the G allele in the recurrent group (P = .001). Multivariable logistic regression analysis showed that smoking (OR = 5.228, 95% CI: 1.938-14.102, P = .001), coronary heart disease (OR = 4.754, 95% CI: 1.498-15.089, P = .008), and the polymorphism at PTGS1(A>G) AA/AG + GG (OR = 2.955, 95% CI: 1.320-6.616, P = .008) were independently associated with IS recurrence in Chinese patients. Our findings suggested that PTGS rs10306114 polymorphisms should receive more attention in the use of aspirin in patients with IS.Platelet endothelial aggregation receptor 1 (PEAR1) and prostaglandin endoperoxide synthase 1 (PTGS1) polymorphisms can affect laboratory aspirin resistance. However, the impact of genetic polymorphisms on the recurrence of ischemic stroke (IS) patients treated with aspirin is not fully understood. This study aimed to examine the relationship between gene polymorphisms of PEAR1 and PTGS1 and IS recurrence in patients treated with aspirin. Peripheral blood samples were collected from 174 patients with nonrecurrent IS and 34 with recurrent IS after aspirin treatment. Follow-up was performed on all patients. PEAR1 rs12041331 and PTGS1 rs10306114 polymorphisms were determined using the PCR fluorescence probe method. And the correlations of them with the clinical characteristics were examined by multivariable logistic regression analysis. The distribution frequencies of PEAR1 rs12041331 and PTGS1 rs10306114 genotypes were in Hardy-Weinberg equilibrium, and there was no significant difference in the distribution of PEAR1 rs12041331 polymorphism. Compared to the nonrecurrent group, the AA genotype of the PTGS1 polymorphism was more frequent in the recurrent group (59.77% vs 35.29%, P = .003), and the A allele also showed a higher frequency than the G allele in the recurrent group (P = .001). Multivariable logistic regression analysis showed that smoking (OR = 5.228, 95% CI: 1.938-14.102, P = .001), coronary heart disease (OR = 4.754, 95% CI: 1.498-15.089, P = .008), and the polymorphism at PTGS1(A>G) AA/AG + GG (OR = 2.955, 95% CI: 1.320-6.616, P = .008) were independently associated with IS recurrence in Chinese patients. Our findings suggested that PTGS rs10306114 polymorphisms should receive more attention in the use of aspirin in patients with IS. |
| Author | Zhang, Linlin Meng, Zhongru Wang, Hongxia Miao, Yang |
| Author_xml | – sequence: 1 givenname: Linlin surname: Zhang fullname: Zhang, Linlin email: 1515605617@qq.com organization: Department of Pharmacology, the First People's Hospital of Yancheng, Yancheng 224000, Jiangsu, China – sequence: 2 givenname: Zhongru surname: Meng fullname: Meng, Zhongru email: 1158234705@qq.com organization: Department of Pharmacology, the First People's Hospital of Yancheng, Yancheng 224000, Jiangsu, China – sequence: 3 givenname: Hongxia surname: Wang fullname: Wang, Hongxia email: 805353057@qq.com organization: Department of Pharmacology, the First People's Hospital of Yancheng, Yancheng 224000, Jiangsu, China – sequence: 4 givenname: Yang orcidid: 0009-0009-1543-2731 surname: Miao fullname: Miao, Yang email: myang88508706@163.com organization: Department of Pharmacology, the First People's Hospital of Yancheng, Yancheng 224000, Jiangsu, China |
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| Cites_doi | 10.1016/j.biopha.2022.113845 10.1038/aps.2016.90 10.1253/circj.CJ-12-1421 10.1016/j.jstrokecerebrovasdis.2016.05.039 10.1161/CIRCULATIONAHA.116.025250 10.1159/000274804 10.2217/pgs-2019-0133 10.1080/17425255.2017.1363887 10.2217/pgs-2022-0033 10.1001/jamaneurol.2021.5080 10.1177/1074248407310869 10.1001/jamanetworkopen.2023.1455 10.1038/s41467-022-34870-w 10.3390/biomedicines10102564 10.1016/j.thromres.2018.01.026 10.3389/fcvm.2021.664012 10.3390/genes14101840 10.1080/09537104.2020.1863938 10.2174/1381612823666170817122043 10.1186/s12883-016-0788-8 10.2174/138161206775193064 10.1111/j.1538-7836.2004.0615d.x 10.5114/aoms/159180 10.1097/01.crd.0000148175.60718.69 10.1159/000488101 10.1016/j.yexcr.2018.03.027 10.1161/CIRCINTERVENTIONS.118.007019 10.1371/journal.pone.0111816 10.1016/j.jns.2017.03.014 10.1007/s11239-020-02149-w 10.1016/j.thromres.2016.02.031 10.1016/j.pharmthera.2013.08.005 10.1177/1076029612444002 10.1002/cpt.1959 10.1161/STROKEAHA.121.034378 10.1093/cvr/cvv193 10.2174/1381612043453144 10.1023/A:1022066305399 10.1159/000342489 10.1016/S0140-6736(06)68040-9 10.1016/j.jcma.2012.08.018 10.1097/MD.0000000000005687 10.1111/cts.12438 |
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| Issue | 19 |
| Keywords | recurrence aspirin gene polymorphisms ischemic stroke |
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| License | http://creativecommons.org/licenses/by/4.0 Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Notes | Received: 21 August 2023 / Received in final form: 24 March 2024 / Accepted: 5 April 2024 LZ and ZM contributed equally to this work. The authors have no conflicts of interest to disclose. This work was supported by grants from the Health Commission Medical Research Project of Yancheng, China (No. YK2023057), Jiangsu Research Hospital Association for Precision Medication (no. JY202135), and Jiangsu Pharmaceutical Association (no. H202135). The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. All procedures were performed in accordance with the Declaration of Helsinki. This study was approved by the Ethics Committee of First People's Hospital of Yancheng (no. 2021-K-79). How to cite this article: Zhang L, Meng Z, Wang H, Miao Y. Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study. Medicine 2024;103:19(e38031). * Correspondence: Yang Miao, Department of Pharmacology, The First People's Hospital of Yancheng, 66 South Renmin Road, Yancheng, Jiangsu 224000, China (e-mail: myang88508706@163.com). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| Snippet | Platelet endothelial aggregation receptor 1 (PEAR1) and prostaglandin endoperoxide synthase 1 (PTGS1) polymorphisms can affect laboratory aspirin resistance.... Platelet endothelial aggregation receptor 1 ( PEAR1 ) and prostaglandin endoperoxide synthase 1 ( PTGS1 ) polymorphisms can affect laboratory aspirin... |
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| SubjectTerms | Aged Asian People - genetics Aspirin - therapeutic use China - epidemiology Cyclooxygenase 1 - genetics Diagnostic Accuracy Study Female Follow-Up Studies Genotype Humans Ischemic Stroke - drug therapy Ischemic Stroke - genetics Male Middle Aged Platelet Aggregation Inhibitors - therapeutic use Polymorphism, Single Nucleotide Receptors, Cell Surface - genetics Recurrence |
| Title | Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study |
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