BMI and Outcomes of SARS‐CoV‐2 Among US Veterans

Objective The purpose of this study is to examine the associations of BMI with testing positive for severe acute respiratory coronavirus 2 (SARS‐CoV‐2) and risk of adverse outcomes in a cohort of Veterans Affairs enrollees. Method Adjusted relative risks/hazard ratios (HRs) were calculated for the a...

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Vol. 29; no. 5; pp. 900 - 908
Main Authors: Eastment, McKenna C., Berry, Kristin, Locke, Emily, Green, Pamela, O’Hare, Ann, Crothers, Kristina, Dominitz, Jason A., Fan, Vincent S., Shah, Javeed A., Ioannou, George N.
Format: Journal Article
Language:English
Published: United States Blackwell Publishing Ltd 01.05.2021
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Body Mass Index
Cardiovascular disease
Cohort Studies
Comorbidity
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 - mortality
Data warehouses
Diabetes
Female
Hospitalization
Humans
Intensive care
Intensive Care Units
Male
Middle Aged
Mortality
Obesity
Obesity - complications
Overweight
Patients
Proportional Hazards Models
Respiration, Artificial
Risk Factors
Severe acute respiratory syndrome coronavirus 2
Sociodemographics
Ventilators
Veterans
Veterans - statistics & numerical data
Young Adult
United States > US
ISSN:1930-7381, 1930-739X, 1930-739X
Online Access:Get full text
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Summary:Objective The purpose of this study is to examine the associations of BMI with testing positive for severe acute respiratory coronavirus 2 (SARS‐CoV‐2) and risk of adverse outcomes in a cohort of Veterans Affairs enrollees. Method Adjusted relative risks/hazard ratios (HRs) were calculated for the associations between BMI category (underweight, normal weight, overweight, class 1 obesity, class 2 obesity, and class 3 obesity) and testing positive for SARS‐CoV‐2 or experiencing hospitalization, intensive care unit admission, mechanical ventilation, and death among those testing positive. Results Higher BMI categories were associated with higher risk of a positive SARS‐CoV‐2 test compared with the normal weight category (class 3 obesity adjusted relative risk: 1.34, 95% CI: 1.28‐1.42). Among 25,952 patients who tested positive for SARS‐CoV‐2, class 3 obesity was associated with higher risk of mechanical ventilation (adjusted HR [aHR]: 1.77, 95% CI: 1.35‐2.32) and mortality (aHR: 1.42, 95% CI: 1.12‐1.78) compared with normal weight individuals. These associations were present primarily in patients younger than 65 and were attenuated or absent in older age groups (interaction P < 0.05). Conclusion Veterans Affairs enrollees with higher BMI were more likely to test positive for SARS‐CoV‐2 and were more likely to be mechanically ventilated or die if infected with SARS‐CoV‐2. Higher BMI contributed relatively more to the risk of death in those younger than 65 years of age as compared with other age categories.
Bibliography:See Commentary
pg. 786.
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ISSN:1930-7381
1930-739X
1930-739X
DOI:10.1002/oby.23111