Effect of membrane exposure on guided bone regeneration: A systematic review and meta‐analysis

Aims This review aimed at investigating the effect of membrane exposure on guided bone regeneration (GBR) outcomes at peri‐implant sites and edentulous ridges. Material and Methods Electronic and manual literature searches were conducted by two independent reviewers using four databases, including M...

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Vydáno v:Clinical oral implants research Ročník 29; číslo 3; s. 328 - 338
Hlavní autoři: Garcia, Jeffrey, Dodge, Austin, Luepke, Paul, Wang, Hom‐Lay, Kapila, Yvonne, Lin, Guo‐Hao
Médium: Journal Article
Jazyk:angličtina
Vydáno: Denmark Wiley Subscription Services, Inc 01.03.2018
Témata:
Alveolar Ridge Augmentation
Augmentation
Bone growth
Bone Regeneration
Bone Transplantation
Clinical trials
Confidence intervals
Databases, Factual
Dehiscence
Dental Implantation, Endosseous
evidence‐based dentistry
Exposure
Guided Tissue Regeneration, Periodontal - methods
Humans
Literature reviews
Medical research
Membranes, Artificial
Meta-analysis
Mouth, Edentulous
Quantitative analysis
Regeneration
Regeneration (physiology)
review
surgical wound dehiscence
Treatment Outcome
Wound Healing
meta-analysis
bone regeneration
surgical wound dehiscence
alveolar ridge augmentation
evidence-based dentistry
review
ISSN:0905-7161, 1600-0501, 1600-0501
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Shrnutí:Aims This review aimed at investigating the effect of membrane exposure on guided bone regeneration (GBR) outcomes at peri‐implant sites and edentulous ridges. Material and Methods Electronic and manual literature searches were conducted by two independent reviewers using four databases, including MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials, for articles up to February 2017. Articles were included if they were human clinical trials or case series reporting outcomes of GBR procedures with and without membrane exposure. A random‐effects meta‐analysis was conducted, and the weighted mean difference (WMD) between the two groups and 95% confidence interval (CI) were reported. Results Overall, eight articles were included in the quantitative analysis. The WMD of the horizontal bone gain at edentulous ridges was −76.24% (95% CI = −137.52% to −14.97%, p = .01) between sites with membrane exposure and without exposure. In addition, the WMD of the dehiscence reduction at peri‐implant sites was −27.27% (95% CI of −45.87% to −8.68%, p = .004). Both analyses showed significantly favorable outcomes at the sites without membrane exposure. Conclusion Based on the findings of this study, membrane exposure after GBR procedures has a significant detrimental influence on the outcome of bone augmentation. For the edentulous ridges, the sites without membrane exposure achieved 74% more horizontal bone gain than the sites with exposure. For peri‐implant dehiscence defects, the sites without membrane exposure had 27% more defect reduction than the sites with exposure.
Bibliografie:ObjectType-Article-2
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ObjectType-Evidence Based Healthcare-1
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ISSN:0905-7161
1600-0501
1600-0501
DOI:10.1111/clr.13121