Excessive dietary lipid intake provokes an acquired form of lysosomal lipid storage disease in the kidney

Obesity and dyslipidaemia are features of the metabolic syndrome and risk factors for chronic kidney disease. The cellular mechanisms connecting metabolic syndrome with chronic kidney disease onset and progression remain largely unclear. We show that proximal tubular epithelium is a target site for...

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Bibliographic Details
Published in:	The Journal of pathology Vol. 246; no. 4; pp. 470 - 484
Main Authors:	Rampanelli, Elena, Ochodnicky, Peter, Vissers, Johannes PC, Butter, Loes M, Claessen, Nike, Calcagni, Alessia, Kors, Lotte, Gethings, Lee A, Bakker, Stephan JL, de Borst, Martin H, Navis, Gerjan J, Liebisch, Gerhard, Speijer, Dave, van den Bergh Weerman, Marius A, Jung, Bettina, Aten, Jan, Steenbergen, Eric, Schmitz, Gerd, Ballabio, Andrea, Florquin, Sandrine, Aerts, Johannes MFG, Leemans, Jaklien C
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.12.2018 Wiley Subscription Services, Inc
Subjects:	Cholesterol chronic kidney disease diet Dietary intake Dyslipidemia Epidermis Epithelial cells Epithelium Fibrosis Inflammation kidney Kidney diseases Kidneys Lipids Lipoproteins lysosomal storage disease Lysosomal storage diseases lysosome Lysosomes Metabolic syndrome metabolism multilamellar bodies Obesity Overnutrition Phospholipids Proteomics Risk factors Transcription Urine Vacuoles Well being kidney chronic kidney disease lipids inflammation lysosomal storage disease multilamellar bodies fibrosis metabolism diet lysosome
ISSN:	0022-3417, 1096-9896, 1096-9896
Online Access:	Get full text
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