Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells

Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression (Z4 events) are important for the maintenance of telomere length and genome stability in mESCs. However, the mo...

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Vydané v:	DNA research Ročník 22; číslo 5; s. 307 - 318
Hlavní autori:	Akiyama, Tomohiko, Xin, Li, Oda, Mayumi, Sharov, Alexei A., Amano, Misa, Piao, Yulan, Cadet, J. Scotty, Dudekula, Dawood B., Qian, Yong, Wang, Weidong, Ko, Shigeru B. H., Ko, Minoru S. H.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 01.10.2015
Predmet:	Acetylation Animals Cell Nucleolus - metabolism Chromatin Assembly and Disassembly DNA Methylation Epigenesis, Genetic Genomic Instability Heterochromatin - genetics Histones - metabolism Mice Mouse Embryonic Stem Cells - metabolism Telomere Homeostasis - genetics Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic pericentromere embryonic stem cells heterochromatin
ISSN:	1340-2838, 1756-1663, 1756-1663
On-line prístup:	Získať plný text
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