Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells

Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression (Z4 events) are important for the maintenance of telomere length and genome stability in mESCs. However, the mo...

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Veröffentlicht in:	DNA research Jg. 22; H. 5; S. 307 - 318
Hauptverfasser:	Akiyama, Tomohiko, Xin, Li, Oda, Mayumi, Sharov, Alexei A., Amano, Misa, Piao, Yulan, Cadet, J. Scotty, Dudekula, Dawood B., Qian, Yong, Wang, Weidong, Ko, Shigeru B. H., Ko, Minoru S. H.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 01.10.2015
Schlagworte:	Acetylation Animals Cell Nucleolus - metabolism Chromatin Assembly and Disassembly DNA Methylation Epigenesis, Genetic Genomic Instability Heterochromatin - genetics Histones - metabolism Mice Mouse Embryonic Stem Cells - metabolism Telomere Homeostasis - genetics Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic pericentromere embryonic stem cells heterochromatin
ISSN:	1340-2838, 1756-1663, 1756-1663
Online-Zugang:	Volltext
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