Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells

Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression (Z4 events) are important for the maintenance of telomere length and genome stability in mESCs. However, the mo...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	DNA research Ročník 22; číslo 5; s. 307 - 318
Hlavní autori:	Akiyama, Tomohiko, Xin, Li, Oda, Mayumi, Sharov, Alexei A., Amano, Misa, Piao, Yulan, Cadet, J. Scotty, Dudekula, Dawood B., Qian, Yong, Wang, Weidong, Ko, Shigeru B. H., Ko, Minoru S. H.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 01.10.2015
Predmet:	Acetylation Animals Cell Nucleolus - metabolism Chromatin Assembly and Disassembly DNA Methylation Epigenesis, Genetic Genomic Instability Heterochromatin - genetics Histones - metabolism Mice Mouse Embryonic Stem Cells - metabolism Telomere Homeostasis - genetics Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic pericentromere embryonic stem cells heterochromatin
ISSN:	1340-2838, 1756-1663, 1756-1663
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression (Z4 events) are important for the maintenance of telomere length and genome stability in mESCs. However, the molecular details of Z4 events remain unclear. Here we show that Z4 events involve unexpected transcriptional derepression in heterochromatin regions that usually remain silent. During a Z4 event, we see rapid derepression and rerepression of heterochromatin leading to a burst of transcription that coincides with transient histone hyperacetylation and DNA demethylation, clustering of pericentromeric heterochromatin around the nucleolus, and accumulation of activating and repressive chromatin remodelling complexes. This heterochromatin-based transcriptional activity suggests that mESCs may maintain their extraordinary genome stability at least in part by transiently resetting their heterochromatin.
AbstractList	Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression (Z4 events) are important for the maintenance of telomere length and genome stability in mESCs. However, the molecular details of Z4 events remain unclear. Here we show that Z4 events involve unexpected transcriptional derepression in heterochromatin regions that usually remain silent. During a Z4 event, we see rapid derepression and rerepression of heterochromatin leading to a burst of transcription that coincides with transient histone hyperacetylation and DNA demethylation, clustering of pericentromeric heterochromatin around the nucleolus, and accumulation of activating and repressive chromatin remodelling complexes. This heterochromatin-based transcriptional activity suggests that mESCs may maintain their extraordinary genome stability at least in part by transiently resetting their heterochromatin. Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression (Z4 events) are important for the maintenance of telomere length and genome stability in mESCs. However, the molecular details of Z4 events remain unclear. Here we show that Z4 events involve unexpected transcriptional derepression in heterochromatin regions that usually remain silent. During a Z4 event, we see rapid derepression and rerepression of heterochromatin leading to a burst of transcription that coincides with transient histone hyperacetylation and DNA demethylation, clustering of pericentromeric heterochromatin around the nucleolus, and accumulation of activating and repressive chromatin remodelling complexes. This heterochromatin-based transcriptional activity suggests that mESCs may maintain their extraordinary genome stability at least in part by transiently resetting their heterochromatin.Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that infrequent bursts of Zscan4 expression (Z4 events) are important for the maintenance of telomere length and genome stability in mESCs. However, the molecular details of Z4 events remain unclear. Here we show that Z4 events involve unexpected transcriptional derepression in heterochromatin regions that usually remain silent. During a Z4 event, we see rapid derepression and rerepression of heterochromatin leading to a burst of transcription that coincides with transient histone hyperacetylation and DNA demethylation, clustering of pericentromeric heterochromatin around the nucleolus, and accumulation of activating and repressive chromatin remodelling complexes. This heterochromatin-based transcriptional activity suggests that mESCs may maintain their extraordinary genome stability at least in part by transiently resetting their heterochromatin.
Author	Piao, Yulan Amano, Misa Cadet, J. Scotty Ko, Shigeru B. H. Ko, Minoru S. H. Wang, Weidong Qian, Yong Dudekula, Dawood B. Akiyama, Tomohiko Xin, Li Oda, Mayumi Sharov, Alexei A.
Author_xml	– sequence: 1 givenname: Tomohiko surname: Akiyama fullname: Akiyama, Tomohiko – sequence: 2 givenname: Li surname: Xin fullname: Xin, Li – sequence: 3 givenname: Mayumi surname: Oda fullname: Oda, Mayumi – sequence: 4 givenname: Alexei A. surname: Sharov fullname: Sharov, Alexei A. – sequence: 5 givenname: Misa surname: Amano fullname: Amano, Misa – sequence: 6 givenname: Yulan surname: Piao fullname: Piao, Yulan – sequence: 7 givenname: J. Scotty surname: Cadet fullname: Cadet, J. Scotty – sequence: 8 givenname: Dawood B. surname: Dudekula fullname: Dudekula, Dawood B. – sequence: 9 givenname: Yong surname: Qian fullname: Qian, Yong – sequence: 10 givenname: Weidong surname: Wang fullname: Wang, Weidong – sequence: 11 givenname: Shigeru B. H. surname: Ko fullname: Ko, Shigeru B. H. – sequence: 12 givenname: Minoru S. H. surname: Ko fullname: Ko, Minoru S. H.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26324425$$D View this record in MEDLINE/PubMed
BookMark	eNp1kcuLFDEQxoOsuA89epUcvbSbd6Yvgiy-YMHLevES8qh2It1Jm2QW5-afboZZBxWEkCrIr74vVXWJzlJOgNBzSl5RMvLrkGyBeh3qPaH8EbqgWqqBKsXPes4FGdiGb87RZa3fCBFUcv0EnTPFmRBMXqCfd8WmGiE17HaltorzhL9Ub5PA8GPt0jXmhLsHtt7nZbUpQsBuj9sWcLFrDDhAgRPZy7fQoGS_LXmxLSbcz5J3FTAsruxzih7XBgv2MM_1KXo82bnCs4d4hT6_e3t382G4_fT-482b28ELydsAygGXLoz9FlqSoCUjI_PaKdHD5Imc7Ois59oy5hQBurEyqA2fHEhr-RV6fdRdd26B4HvHxc5mLXGxZW-yjebvlxS35mu-N0KOio-6C7x8ECj5-w5qM0ushxZsgt6doZr1eWsqVEdf_Ol1Mvk99g4MR8CXXGuB6YRQYg5rNce1muNaO8__4X1sfbb58NU4_6fqF9UnrkY
CitedBy_id	crossref_primary_10_1016_j_jmb_2016_12_009 crossref_primary_10_1016_j_tig_2016_10_007 crossref_primary_10_1016_j_cels_2016_10_015 crossref_primary_10_3390_cells11030548 crossref_primary_10_1093_hmg_ddab352 crossref_primary_10_1371_journal_pbio_3000324 crossref_primary_10_3390_ijms242216019 crossref_primary_10_1016_j_stem_2018_05_025 crossref_primary_10_15252_embr_201948942 crossref_primary_10_1016_j_cels_2020_06_004 crossref_primary_10_1016_j_jbc_2021_101367 crossref_primary_10_7554_eLife_87742 crossref_primary_10_1038_s41556_019_0453_8 crossref_primary_10_1093_biolre_ioab141 crossref_primary_10_1038_s41467_021_26576_2 crossref_primary_10_1038_s41467_024_46121_1 crossref_primary_10_1016_j_bbrc_2018_02_155 crossref_primary_10_3390_ijms25073898 crossref_primary_10_1093_hmg_ddad021 crossref_primary_10_1093_nar_gkaf504 crossref_primary_10_1111_cpr_13534 crossref_primary_10_1007_s00412_017_0656_3 crossref_primary_10_1007_s11626_016_0013_5 crossref_primary_10_1007_s11626_016_0096_z crossref_primary_10_1038_s41388_020_1333_1 crossref_primary_10_1093_humupd_dmaf006 crossref_primary_10_1093_nar_gkx884 crossref_primary_10_1016_j_gde_2020_06_008 crossref_primary_10_1016_j_jgg_2020_02_003 crossref_primary_10_1038_s44318_025_00488_z crossref_primary_10_1016_j_stem_2020_11_018 crossref_primary_10_1242_dev_139360 crossref_primary_10_1038_s41418_019_0359_9 crossref_primary_10_1038_ng_3846 crossref_primary_10_1093_nar_gkz594 crossref_primary_10_3390_ijms241512121 crossref_primary_10_1038_s41556_022_00928_6 crossref_primary_10_7554_eLife_87742_3 crossref_primary_10_1101_gad_321174_118 crossref_primary_10_3390_cells10113111 crossref_primary_10_1093_stmcls_sxae029 crossref_primary_10_1186_s13287_024_04027_1 crossref_primary_10_1134_S0006297923110068 crossref_primary_10_1038_s41580_018_0008_z crossref_primary_10_1038_s41467_018_05038_2 crossref_primary_10_1038_s41467_025_62303_x crossref_primary_10_1007_s11626_016_0097_y crossref_primary_10_1093_stmcls_sxad051 crossref_primary_10_1073_pnas_2407490121 crossref_primary_10_1016_j_molcel_2020_06_001 crossref_primary_10_1242_dev_189688 crossref_primary_10_1016_j_celrep_2024_114077 crossref_primary_10_1242_dev_189845 crossref_primary_10_1093_humupd_dmx026 crossref_primary_10_3389_fcell_2022_1024093 crossref_primary_10_3389_fcell_2021_703466 crossref_primary_10_7554_eLife_54756
Cites_doi	10.1073/pnas.1016071107 10.1016/j.molcel.2007.09.011 10.1038/nature06008 10.1371/journal.pone.0089821 10.1038/emboj.2010.318 10.1023/A:1018418914106 10.1016/j.celrep.2013.04.034 10.1038/nrc3091 10.1371/journal.pgen.1002279 10.1126/science.1211222 10.1016/j.cell.2006.02.041 10.1152/ajpgi.00299.2012 10.1016/j.tig.2008.08.002 10.1038/nature06968 10.1016/j.ydbio.2007.05.003 10.1007/s00412-013-0439-4 10.1038/nature08514 10.1126/science.1200801 10.1016/j.stem.2009.07.012 10.1073/pnas.0909344107 10.1016/j.stem.2009.05.015 10.1371/journal.pgen.1002090 10.1101/gad.2027411 10.1038/ncb1685 10.1083/jcb.200403109 10.1073/pnas.78.12.7634 10.1038/nature08882 10.1139/O10-113 10.1016/j.semcancer.2012.06.008 10.1093/dnares/dst018 10.1242/dev.102624 10.1016/j.devcel.2005.10.017 10.1146/annurev-cellbio-100913-013116 10.1038/nrg2047 10.1146/annurev-cellbio-101512-122415 10.1016/j.gene.2005.06.022 10.1016/j.cell.2010.10.019 10.1098/rstb.2013.0540 10.1371/journal.pgen.1002093 10.1242/jcs.01390 10.1038/nature10716 10.1111/j.1432-0436.2007.00220.x 10.1016/S0092-8674(02)00868-1 10.1371/journal.pbio.1000379 10.1038/ncomms2966 10.1073/pnas.90.18.8424 10.1098/rstb.2013.0549 10.1016/j.gep.2007.10.009 10.1038/309255a0 10.1038/nature02625 10.1002/jcp.1041330127 10.1016/j.gde.2013.06.003 10.1095/biolreprod.102.007906 10.1038/292154a0 10.1016/j.devcel.2010.09.002 10.1016/S0092-8674(02)00644-X 10.1186/1471-2121-6-44 10.1186/1756-8935-8-3 10.1186/gb-2010-11-4-r36 10.1242/dev.064741 10.1038/nature06403 10.1016/S1534-5807(03)00373-3
ContentType	Journal Article
Copyright	Published by Oxford University Press on behalf of Kazusa DNA Research Institute 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US. Published by Oxford University Press on behalf of Kazusa DNA Research Institute 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US. 2015
Copyright_xml	– notice: Published by Oxford University Press on behalf of Kazusa DNA Research Institute 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US. – notice: Published by Oxford University Press on behalf of Kazusa DNA Research Institute 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US. 2015
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM
DOI	10.1093/dnares/dsv013
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1756-1663
EndPage	318
ExternalDocumentID	PMC4596397 26324425 10_1093_dnares_dsv013
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Intramural
GrantInformation_xml	– fundername: NIA NIH HHS grantid: AG000702 – fundername: Intramural NIH HHS – fundername: NIA NIH HHS grantid: AG000656 – fundername: National Institutes of Health (AG000656, AG000702) – fundername: The Mitsunada Sakaguchi Laboratory – fundername: National Institute on Aging – fundername: Keio University Medical Science Fund – fundername: Takeda Science Foundation
GroupedDBID	--- .I3 0R~ 18M 29G 2WC 4.4 53G 5GY 5VS 5WA 70E AAFWJ AAHBH AAMVS AAOGV AAPXW AAVAP AAYXX ABEJV ABGNP ABPTD ABQLI ABSMQ ABXVV ACFRR ACGFO ACGFS ACUTJ ACVCV ADBBV ADHZD ADRAZ AEGXH AENEX AENZO AFPKN AGMDO AIAGR ALMA_UNASSIGNED_HOLDINGS ALUQC AMNDL AOIJS APJGH ASAOO ATDFG BAWUL BAYMD BCNDV C1A CIDKT CITATION CS3 CXTWN CZ4 DFGAJ DIK DU5 D~K E3Z EBD EBS EJD EMOBN F5P GROUPED_DOAJ GX1 H13 HH5 HYE HZ~ KQ8 KSI M48 MBTAY O5R O5S OAWHX OJQWA OK1 OVT O~Y P2P PEELM RD5 RNS ROZ RPM RXO SV3 TOX TR2 WG7 X7H ZKX ~91 ~D7 ~S- ABQTQ CGR CUY CVF ECM EIF NPM 7X8 5PM
ID	FETCH-LOGICAL-c453t-e6be35bd9e354750d752092c7b6492cfc05fa9bac37a22b60e18a5d683fbe5aa3
ISICitedReferencesCount	74
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000362820100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1340-2838 1756-1663
IngestDate	Thu Aug 21 13:41:15 EDT 2025 Wed Oct 01 14:03:44 EDT 2025 Thu Apr 03 07:06:04 EDT 2025 Tue Nov 18 21:19:26 EST 2025 Sat Nov 29 04:41:41 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Keywords	pericentromere embryonic stem cells heterochromatin
Language	English
License	Published by Oxford University Press on behalf of Kazusa DNA Research Institute 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c453t-e6be35bd9e354750d752092c7b6492cfc05fa9bac37a22b60e18a5d683fbe5aa3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Equal contribution first authors. Edited by Dr Osamu Ohara
OpenAccessLink	http://dx.doi.org/10.1093/dnares/dsv013
PMID	26324425
PQID	1721347146
PQPubID	23479
PageCount	12
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_4596397 proquest_miscellaneous_1721347146 pubmed_primary_26324425 crossref_primary_10_1093_dnares_dsv013 crossref_citationtrail_10_1093_dnares_dsv013
PublicationCentury	2000
PublicationDate	2015-10-01
PublicationDateYYYYMMDD	2015-10-01
PublicationDate_xml	– month: 10 year: 2015 text: 2015-10-01 day: 01
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	DNA research
PublicationTitleAlternate	DNA Res
PublicationYear	2015
Publisher	Oxford University Press
Publisher_xml	– name: Oxford University Press
References	2015100708321807000_22.5.307.24 2015100708321807000_22.5.307.23 2015100708321807000_22.5.307.26 2015100708321807000_22.5.307.25 2015100708321807000_22.5.307.28 2015100708321807000_22.5.307.27 2015100708321807000_22.5.307.60 2015100708321807000_22.5.307.62 2015100708321807000_22.5.307.61 2015100708321807000_22.5.307.20 2015100708321807000_22.5.307.63 2015100708321807000_22.5.307.22 2015100708321807000_22.5.307.21 2015100708321807000_22.5.307.6 2015100708321807000_22.5.307.13 2015100708321807000_22.5.307.57 2015100708321807000_22.5.307.5 2015100708321807000_22.5.307.12 2015100708321807000_22.5.307.56 2015100708321807000_22.5.307.4 2015100708321807000_22.5.307.15 2015100708321807000_22.5.307.59 2015100708321807000_22.5.307.3 2015100708321807000_22.5.307.14 2015100708321807000_22.5.307.58 2015100708321807000_22.5.307.2 2015100708321807000_22.5.307.17 2015100708321807000_22.5.307.1 2015100708321807000_22.5.307.16 2015100708321807000_22.5.307.19 Olson (2015100708321807000_22.5.307.29) 2003; 63 2015100708321807000_22.5.307.9 2015100708321807000_22.5.307.8 2015100708321807000_22.5.307.7 2015100708321807000_22.5.307.51 2015100708321807000_22.5.307.50 2015100708321807000_22.5.307.53 2015100708321807000_22.5.307.52 2015100708321807000_22.5.307.11 2015100708321807000_22.5.307.55 2015100708321807000_22.5.307.10 2015100708321807000_22.5.307.54 2015100708321807000_22.5.307.46 2015100708321807000_22.5.307.45 2015100708321807000_22.5.307.48 2015100708321807000_22.5.307.47 2015100708321807000_22.5.307.49 Amano (2015100708321807000_22.5.307.18) 2013; 4 2015100708321807000_22.5.307.40 2015100708321807000_22.5.307.42 2015100708321807000_22.5.307.41 2015100708321807000_22.5.307.44 2015100708321807000_22.5.307.43 2015100708321807000_22.5.307.35 2015100708321807000_22.5.307.34 2015100708321807000_22.5.307.37 2015100708321807000_22.5.307.36 2015100708321807000_22.5.307.39 2015100708321807000_22.5.307.38 2015100708321807000_22.5.307.31 2015100708321807000_22.5.307.30 2015100708321807000_22.5.307.33 2015100708321807000_22.5.307.32 21998593 - PLoS Genet. 2011 Oct;7(10):e1002279 16139965 - Gene. 2005 Oct 10;359:1-17 18497825 - Nature. 2008 May 22;453(7194):519-23 18157120 - Nat Cell Biol. 2008 Feb;10(2):228-36 23932125 - Curr Opin Genet Dev. 2013 Oct;23(5):504-11 24866112 - Development. 2014 Jun;141(11):2173-81 17363977 - Nat Rev Genet. 2007 Apr;8(4):299-309 17825083 - Differentiation. 2008 Jan;76(1):15-23 16399082 - Dev Cell. 2006 Jan;10(1):105-16 20336070 - Nature. 2010 Apr 8;464(7290):858-63 17553482 - Dev Biol. 2007 Jul 15;307(2):539-50 21106759 - Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6 23746443 - Cell Rep. 2013 Jun 27;3(6):1945-57 17603471 - Nature. 2007 Aug 2;448(7153):553-60 21498567 - Genes Dev. 2011 Apr 15;25(8):781-8 22722067 - Semin Cancer Biol. 2013 Apr;23(2):99-108 20951352 - Dev Cell. 2010 Oct 19;19(4):625-38 25000994 - Annu Rev Cell Dev Biol. 2014;30:561-80 20359321 - Genome Biol. 2010;11(4):R36 22170606 - Nature. 2011 Dec 22;480(7378):490-5 23599043 - Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1103-16 3667706 - J Cell Physiol. 1987 Oct;133(1):197-201 6717601 - Nature. 1984 May 17-23;309(5965):255-6 21655081 - PLoS Genet. 2011 Jun;7(6):e1002090 25288119 - Annu Rev Cell Dev Biol. 2014;30:647-75 8378314 - Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8424-8 15331660 - J Cell Sci. 2004 Sep 1;117(Pt 19):4355-63 19796622 - Cell Stem Cell. 2009 Oct 2;5(4):420-33 21326362 - Biochem Cell Biol. 2011 Feb;89(1):45-60 6950406 - Proc Natl Acad Sci U S A. 1981 Dec;78(12):7634-8 21775417 - Development. 2011 Sep;138(17):3699-709 19829295 - Nature. 2009 Nov 19;462(7271):315-22 18778867 - Trends Genet. 2008 Oct;24(10):511-7 21131905 - EMBO J. 2011 Jan 19;30(2):249-62 21655082 - PLoS Genet. 2011 Jun;7(6):e1002093 15302854 - J Cell Biol. 2004 Aug 16;166(4):493-505 23649898 - DNA Res. 2013 Aug;20(4):391-402 25349449 - Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130540. doi: 10.1098/rstb.2013.0540 7242681 - Nature. 1981 Jul 9;292(5819):154-6 21233348 - Science. 2011 Feb 4;331(6017):593-6 18178135 - Gene Expr Patterns. 2008 Feb;8(3):181-98 23739662 - Nat Commun. 2013;4:1966 24126501 - Chromosoma. 2014 Mar;123(1-2):43-55 14583452 - Cancer Res. 2003 Oct 15;63(20):6602-6 12533431 - Biol Reprod. 2003 Feb;68(2):651-4 21734722 - Nat Rev Cancer. 2011 Aug;11(8):588-96 19497275 - Cell Stem Cell. 2009 Jun 5;4(6):487-92 25788984 - Epigenetics Chromatin. 2015 Jan 15;8:3 11909520 - Cell. 2002 Feb 22;108(4):489-500 16336643 - BMC Cell Biol. 2005;6:44 15164071 - Nature. 2004 May 27;429(6990):457-63 17936700 - Mol Cell. 2007 Oct 12;28(1):1-13 24594919 - PLoS One. 2014;9(3):e89821 12176313 - Cell. 2002 Aug 9;110(3):277-80 16630819 - Cell. 2006 Apr 21;125(2):315-26 18097409 - Nature. 2007 Dec 20;450(7173):1230-4 20133639 - Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2926-31 25349456 - Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130549. doi: 10.1098/rstb.2013.0549 22722858 - Nature. 2012 Jul 5;487(7405):57-63 14723852 - Dev Cell. 2004 Jan;6(1):117-31 9322369 - Transgenic Res. 1997 Sep;6(5):321-8 20520791 - PLoS Biol. 2010 May;8(5):e1000379 22116031 - Science. 2011 Dec 23;334(6063):1706-10
References_xml	– ident: 2015100708321807000_22.5.307.34 doi: 10.1073/pnas.1016071107 – ident: 2015100708321807000_22.5.307.26 doi: 10.1016/j.molcel.2007.09.011 – ident: 2015100708321807000_22.5.307.45 doi: 10.1038/nature06008 – ident: 2015100708321807000_22.5.307.21 doi: 10.1371/journal.pone.0089821 – ident: 2015100708321807000_22.5.307.38 doi: 10.1038/emboj.2010.318 – ident: 2015100708321807000_22.5.307.15 doi: 10.1023/A:1018418914106 – ident: 2015100708321807000_22.5.307.12 doi: 10.1016/j.celrep.2013.04.034 – ident: 2015100708321807000_22.5.307.39 doi: 10.1038/nrc3091 – ident: 2015100708321807000_22.5.307.60 doi: 10.1371/journal.pgen.1002279 – ident: 2015100708321807000_22.5.307.36 doi: 10.1126/science.1211222 – ident: 2015100708321807000_22.5.307.44 doi: 10.1016/j.cell.2006.02.041 – ident: 2015100708321807000_22.5.307.57 doi: 10.1152/ajpgi.00299.2012 – ident: 2015100708321807000_22.5.307.25 doi: 10.1016/j.tig.2008.08.002 – ident: 2015100708321807000_22.5.307.8 doi: 10.1038/nature06968 – ident: 2015100708321807000_22.5.307.16 doi: 10.1016/j.ydbio.2007.05.003 – ident: 2015100708321807000_22.5.307.55 doi: 10.1007/s00412-013-0439-4 – ident: 2015100708321807000_22.5.307.47 doi: 10.1038/nature08514 – volume: 63 start-page: 6602 year: 2003 ident: 2015100708321807000_22.5.307.29 article-title: Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1 publication-title: Cancer Res. – ident: 2015100708321807000_22.5.307.49 doi: 10.1126/science.1200801 – ident: 2015100708321807000_22.5.307.30 doi: 10.1016/j.stem.2009.07.012 – ident: 2015100708321807000_22.5.307.42 doi: 10.1073/pnas.0909344107 – ident: 2015100708321807000_22.5.307.9 doi: 10.1016/j.stem.2009.05.015 – ident: 2015100708321807000_22.5.307.37 doi: 10.1371/journal.pgen.1002090 – ident: 2015100708321807000_22.5.307.48 doi: 10.1101/gad.2027411 – ident: 2015100708321807000_22.5.307.54 doi: 10.1038/ncb1685 – ident: 2015100708321807000_22.5.307.41 doi: 10.1083/jcb.200403109 – ident: 2015100708321807000_22.5.307.2 doi: 10.1073/pnas.78.12.7634 – ident: 2015100708321807000_22.5.307.17 doi: 10.1038/nature08882 – ident: 2015100708321807000_22.5.307.53 doi: 10.1139/O10-113 – ident: 2015100708321807000_22.5.307.50 doi: 10.1016/j.semcancer.2012.06.008 – ident: 2015100708321807000_22.5.307.19 doi: 10.1093/dnares/dst018 – ident: 2015100708321807000_22.5.307.61 doi: 10.1242/dev.102624 – ident: 2015100708321807000_22.5.307.46 doi: 10.1016/j.devcel.2005.10.017 – ident: 2015100708321807000_22.5.307.6 doi: 10.1146/annurev-cellbio-100913-013116 – ident: 2015100708321807000_22.5.307.22 doi: 10.1038/nrg2047 – ident: 2015100708321807000_22.5.307.28 doi: 10.1146/annurev-cellbio-101512-122415 – ident: 2015100708321807000_22.5.307.63 doi: 10.1016/j.gene.2005.06.022 – ident: 2015100708321807000_22.5.307.13 doi: 10.1016/j.cell.2010.10.019 – ident: 2015100708321807000_22.5.307.7 doi: 10.1098/rstb.2013.0540 – ident: 2015100708321807000_22.5.307.43 doi: 10.1371/journal.pgen.1002093 – ident: 2015100708321807000_22.5.307.27 doi: 10.1242/jcs.01390 – ident: 2015100708321807000_22.5.307.35 doi: 10.1038/nature10716 – ident: 2015100708321807000_22.5.307.59 doi: 10.1111/j.1432-0436.2007.00220.x – ident: 2015100708321807000_22.5.307.52 doi: 10.1016/S0092-8674(02)00868-1 – ident: 2015100708321807000_22.5.307.10 doi: 10.1371/journal.pbio.1000379 – volume: 4 start-page: 1966 year: 2013 ident: 2015100708321807000_22.5.307.18 article-title: Zscan4 restores the developmental potency of embryonic stem cells publication-title: Nat. Commun. doi: 10.1038/ncomms2966 – ident: 2015100708321807000_22.5.307.14 doi: 10.1073/pnas.90.18.8424 – ident: 2015100708321807000_22.5.307.62 doi: 10.1098/rstb.2013.0549 – ident: 2015100708321807000_22.5.307.20 doi: 10.1016/j.gep.2007.10.009 – ident: 2015100708321807000_22.5.307.3 doi: 10.1038/309255a0 – ident: 2015100708321807000_22.5.307.51 doi: 10.1038/nature02625 – ident: 2015100708321807000_22.5.307.4 doi: 10.1002/jcp.1041330127 – ident: 2015100708321807000_22.5.307.5 doi: 10.1016/j.gde.2013.06.003 – ident: 2015100708321807000_22.5.307.32 doi: 10.1095/biolreprod.102.007906 – ident: 2015100708321807000_22.5.307.1 doi: 10.1038/292154a0 – ident: 2015100708321807000_22.5.307.33 doi: 10.1016/j.devcel.2010.09.002 – ident: 2015100708321807000_22.5.307.23 doi: 10.1016/S0092-8674(02)00644-X – ident: 2015100708321807000_22.5.307.40 doi: 10.1186/1471-2121-6-44 – ident: 2015100708321807000_22.5.307.24 doi: 10.1186/1756-8935-8-3 – ident: 2015100708321807000_22.5.307.31 doi: 10.1186/gb-2010-11-4-r36 – ident: 2015100708321807000_22.5.307.56 doi: 10.1242/dev.064741 – ident: 2015100708321807000_22.5.307.11 doi: 10.1038/nature06403 – ident: 2015100708321807000_22.5.307.58 doi: 10.1016/S1534-5807(03)00373-3 – reference: 24126501 - Chromosoma. 2014 Mar;123(1-2):43-55 – reference: 17553482 - Dev Biol. 2007 Jul 15;307(2):539-50 – reference: 21998593 - PLoS Genet. 2011 Oct;7(10):e1002279 – reference: 18497825 - Nature. 2008 May 22;453(7194):519-23 – reference: 15164071 - Nature. 2004 May 27;429(6990):457-63 – reference: 25349456 - Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130549. doi: 10.1098/rstb.2013.0549 – reference: 18097409 - Nature. 2007 Dec 20;450(7173):1230-4 – reference: 8378314 - Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8424-8 – reference: 22116031 - Science. 2011 Dec 23;334(6063):1706-10 – reference: 23746443 - Cell Rep. 2013 Jun 27;3(6):1945-57 – reference: 23739662 - Nat Commun. 2013;4:1966 – reference: 16139965 - Gene. 2005 Oct 10;359:1-17 – reference: 17825083 - Differentiation. 2008 Jan;76(1):15-23 – reference: 12533431 - Biol Reprod. 2003 Feb;68(2):651-4 – reference: 18178135 - Gene Expr Patterns. 2008 Feb;8(3):181-98 – reference: 17603471 - Nature. 2007 Aug 2;448(7153):553-60 – reference: 25788984 - Epigenetics Chromatin. 2015 Jan 15;8:3 – reference: 20520791 - PLoS Biol. 2010 May;8(5):e1000379 – reference: 24594919 - PLoS One. 2014;9(3):e89821 – reference: 22170606 - Nature. 2011 Dec 22;480(7378):490-5 – reference: 21655082 - PLoS Genet. 2011 Jun;7(6):e1002093 – reference: 21775417 - Development. 2011 Sep;138(17):3699-709 – reference: 21233348 - Science. 2011 Feb 4;331(6017):593-6 – reference: 16336643 - BMC Cell Biol. 2005;6:44 – reference: 25288119 - Annu Rev Cell Dev Biol. 2014;30:647-75 – reference: 6717601 - Nature. 1984 May 17-23;309(5965):255-6 – reference: 20359321 - Genome Biol. 2010;11(4):R36 – reference: 14583452 - Cancer Res. 2003 Oct 15;63(20):6602-6 – reference: 11909520 - Cell. 2002 Feb 22;108(4):489-500 – reference: 22722067 - Semin Cancer Biol. 2013 Apr;23(2):99-108 – reference: 17363977 - Nat Rev Genet. 2007 Apr;8(4):299-309 – reference: 21734722 - Nat Rev Cancer. 2011 Aug;11(8):588-96 – reference: 19497275 - Cell Stem Cell. 2009 Jun 5;4(6):487-92 – reference: 21655081 - PLoS Genet. 2011 Jun;7(6):e1002090 – reference: 16630819 - Cell. 2006 Apr 21;125(2):315-26 – reference: 14723852 - Dev Cell. 2004 Jan;6(1):117-31 – reference: 21326362 - Biochem Cell Biol. 2011 Feb;89(1):45-60 – reference: 21131905 - EMBO J. 2011 Jan 19;30(2):249-62 – reference: 23599043 - Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1103-16 – reference: 18157120 - Nat Cell Biol. 2008 Feb;10(2):228-36 – reference: 25349449 - Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130540. doi: 10.1098/rstb.2013.0540 – reference: 23932125 - Curr Opin Genet Dev. 2013 Oct;23(5):504-11 – reference: 18778867 - Trends Genet. 2008 Oct;24(10):511-7 – reference: 20133639 - Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2926-31 – reference: 15302854 - J Cell Biol. 2004 Aug 16;166(4):493-505 – reference: 6950406 - Proc Natl Acad Sci U S A. 1981 Dec;78(12):7634-8 – reference: 7242681 - Nature. 1981 Jul 9;292(5819):154-6 – reference: 25000994 - Annu Rev Cell Dev Biol. 2014;30:561-80 – reference: 12176313 - Cell. 2002 Aug 9;110(3):277-80 – reference: 19829295 - Nature. 2009 Nov 19;462(7271):315-22 – reference: 20336070 - Nature. 2010 Apr 8;464(7290):858-63 – reference: 20951352 - Dev Cell. 2010 Oct 19;19(4):625-38 – reference: 23649898 - DNA Res. 2013 Aug;20(4):391-402 – reference: 21498567 - Genes Dev. 2011 Apr 15;25(8):781-8 – reference: 15331660 - J Cell Sci. 2004 Sep 1;117(Pt 19):4355-63 – reference: 17936700 - Mol Cell. 2007 Oct 12;28(1):1-13 – reference: 3667706 - J Cell Physiol. 1987 Oct;133(1):197-201 – reference: 24866112 - Development. 2014 Jun;141(11):2173-81 – reference: 9322369 - Transgenic Res. 1997 Sep;6(5):321-8 – reference: 21106759 - Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6 – reference: 16399082 - Dev Cell. 2006 Jan;10(1):105-16 – reference: 19796622 - Cell Stem Cell. 2009 Oct 2;5(4):420-33 – reference: 22722858 - Nature. 2012 Jul 5;487(7405):57-63
SSID	ssj0041537
Score	2.4132154
Snippet	Mouse embryonic stem cells (mESCs) have a remarkable capacity to maintain normal genome stability and karyotype in culture. We previously showed that...
SourceID	pubmedcentral proquest pubmed crossref
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	307
SubjectTerms	Acetylation Animals Cell Nucleolus - metabolism Chromatin Assembly and Disassembly DNA Methylation Epigenesis, Genetic Genomic Instability Heterochromatin - genetics Histones - metabolism Mice Mouse Embryonic Stem Cells - metabolism Telomere Homeostasis - genetics Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic
Title	Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells
URI	https://www.ncbi.nlm.nih.gov/pubmed/26324425 https://www.proquest.com/docview/1721347146 https://pubmed.ncbi.nlm.nih.gov/PMC4596397
Volume	22
WOSCitedRecordID	wos000362820100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: Open Access: DOAJ - Directory of Open Access Journals customDbUrl: eissn: 1756-1663 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041537 issn: 1340-2838 databaseCode: DOA dateStart: 19940101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVASL databaseName: Oxford Academic Journals (Open Access) customDbUrl: eissn: 1756-1663 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041537 issn: 1340-2838 databaseCode: TOX dateStart: 19960101 isFulltext: true titleUrlDefault: https://academic.oup.com/journals/ providerName: Oxford University Press
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Nb5swFLfSbpN2mfa97CPypKkXhppgwHCMtlY7ROkOdEK7IBuMgtpAlqRRc9s_sf9379lASLtJ3WFS5CBjMPH7xX48v_d7hHxQYpS6LJA27orZLuOpHfpOBu88kjMBclY6kPbbhE-nQRyHX3u9X00szOaSl2VwfR0u_quooQ6EjaGz_yDu9qZQAccgdChB7FDeTfC4-mCUowXjtTKuGt9XMIIu0vkbt9fSQocvkWoP9LLRQtHZUCyKzMIEnm1LrU3C6FfpbFmhfqt9I9FioCw1l8utzqGDfNAW7gKsuuru5-nYqumEWrPz-KLYirnWWaNqXs2Ki6o5FRtCg0nRmn4zYQKKtlfzthI5pqtNE52jitocW5suRl7rBNfMthxJEP16hlN_qKunaMfpQNHrzLfMpMy9tQ4YjqysxBguPFhthiO2W_Kabf7pWXJ6Ppkk0UkcHS1-2JiMDDft68wsB-Sew70QJ8voLG4WeFB5NBVr-6Q1dSv0eWx6PDb97as6t95fbrrhdvSa6DF5VL-Q0LEB0hPSU-VT8sCkKN0-Iz9bOFEDJ1rl1MCJ7uBE4XloB05UbinAiWo40S6c8PIbcKLw0XCiLZwowolqOD0n56cn0acvdp21w05dj61t5UvFPJmFULqgj2YcPa2clEvfha88HXq5CKVIGReOI_2hGgXCy_yA5VJ5QrAX5LCsSvWKUD_1sjDnucg4qPWphMsk43woJc_ykcj75GMzwElaU9pjZpXLxLhWsMTIIzHy6JOjtvnCcLn8reH7RloJzLb4a0WpYCASNJgw0Odcv09eGum1t9KZD2AJ7BO-J9e2ATK5758pi5lmdHe9EDfYX9-h3zfk4e6v9JYcrpdX6h25n27WxWo5IAc8DgbasDTQoP0NOQvMWA
linkProvider	Oxford University Press
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transient+bursts+of+Zscan4+expression+are+accompanied+by+the+rapid+derepression+of+heterochromatin+in+mouse+embryonic+stem+cells&rft.jtitle=DNA+research&rft.au=Akiyama%2C+Tomohiko&rft.au=Xin%2C+Li&rft.au=Oda%2C+Mayumi&rft.au=Sharov%2C+Alexei+A&rft.date=2015-10-01&rft.issn=1756-1663&rft.eissn=1756-1663&rft.volume=22&rft.issue=5&rft.spage=307&rft_id=info:doi/10.1093%2Fdnares%2Fdsv013&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1340-2838&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1340-2838&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1340-2838&client=summon