Safety and Immunogenicity of an mRNA-Based RSV Vaccine Including a 12-Month Booster in a Phase 1 Clinical Trial in Healthy Older Adults
Abstract Background An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults. Methods Based on a randomized, observer-blind, placebo-controlled design, this phase 1 dose-ranging study evaluated the safety, react...
Uložené v:
| Vydané v: | The Journal of infectious diseases Ročník 230; číslo 3; s. e647 - e656 |
|---|---|
| Hlavní autori: | , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
US
Oxford University Press
23.09.2024
|
| Predmet: | |
| ISSN: | 0022-1899, 1537-6613, 1537-6613 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Abstract
Background
An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults.
Methods
Based on a randomized, observer-blind, placebo-controlled design, this phase 1 dose-ranging study evaluated the safety, reactogenicity, and immunogenicity of mRNA-1345 in adults aged 65 to 79 years. Participants were randomized to receive 1 dose of mRNA-1345 (12.5, 25, 50, 100, or 200 µg) or placebo and matched mRNA-1345 booster or placebo at 12 months.
Results
Overall, 298 participants received the first injection and 247 received the 12-month booster injection. mRNA-1345 was generally well tolerated after both injections, with the most frequently reported solicited adverse reactions being injection site pain, fatigue, headache, arthralgia, and myalgia. Reactogenicity was higher after the booster injection but with severity, time to onset, and duration similar to the first injection. A single mRNA-1345 injection boosted RSV-A and RSV-B neutralizing antibody titers and prefusion F binding antibody (preF bAb) concentrations at 1 month (geometric mean fold rises: RSV-A, 10.2–16.5; RSV-B, 5.3–12.5; preF bAb, 7.2–12.1). RSV antibody levels remained above baseline through 12 months, indicating immune persistence. A 12-month booster injection also increased RSV-A and RSV-B neutralizing antibody titers and preF bAb concentrations; titers after booster injection were numerically lower than those after the first dose, with overlapping 95% CIs.
Conclusions
mRNA-1345 was well tolerated and immunogenic following a single injection and a 12-month booster.
Clinical Trials Registration
NCT04528719 (ClinicalTrials.gov).
Older adults and those with comorbidities are at increased risk of severe RSV. We assessed the safety and immunogenicity of mRNA-1345, an RSV vaccine, in adults aged 65 to 79 years. mRNA-1345 was well tolerated and immunogenic following a single injection and 12-month booster. |
|---|---|
| AbstractList | Abstract
Background
An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults.
Methods
Based on a randomized, observer-blind, placebo-controlled design, this phase 1 dose-ranging study evaluated the safety, reactogenicity, and immunogenicity of mRNA-1345 in adults aged 65 to 79 years. Participants were randomized to receive 1 dose of mRNA-1345 (12.5, 25, 50, 100, or 200 µg) or placebo and matched mRNA-1345 booster or placebo at 12 months.
Results
Overall, 298 participants received the first injection and 247 received the 12-month booster injection. mRNA-1345 was generally well tolerated after both injections, with the most frequently reported solicited adverse reactions being injection site pain, fatigue, headache, arthralgia, and myalgia. Reactogenicity was higher after the booster injection but with severity, time to onset, and duration similar to the first injection. A single mRNA-1345 injection boosted RSV-A and RSV-B neutralizing antibody titers and prefusion F binding antibody (preF bAb) concentrations at 1 month (geometric mean fold rises: RSV-A, 10.2–16.5; RSV-B, 5.3–12.5; preF bAb, 7.2–12.1). RSV antibody levels remained above baseline through 12 months, indicating immune persistence. A 12-month booster injection also increased RSV-A and RSV-B neutralizing antibody titers and preF bAb concentrations; titers after booster injection were numerically lower than those after the first dose, with overlapping 95% CIs.
Conclusions
mRNA-1345 was well tolerated and immunogenic following a single injection and a 12-month booster.
Clinical Trials Registration
NCT04528719 (ClinicalTrials.gov).
Older adults and those with comorbidities are at increased risk of severe RSV. We assessed the safety and immunogenicity of mRNA-1345, an RSV vaccine, in adults aged 65 to 79 years. mRNA-1345 was well tolerated and immunogenic following a single injection and 12-month booster. An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults.BACKGROUNDAn mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults.Based on a randomized, observer-blind, placebo-controlled design, this phase 1 dose-ranging study evaluated the safety, reactogenicity, and immunogenicity of mRNA-1345 in adults aged 65 to 79 years. Participants were randomized to receive 1 dose of mRNA-1345 (12.5, 25, 50, 100, or 200 µg) or placebo and matched mRNA-1345 booster or placebo at 12 months.METHODSBased on a randomized, observer-blind, placebo-controlled design, this phase 1 dose-ranging study evaluated the safety, reactogenicity, and immunogenicity of mRNA-1345 in adults aged 65 to 79 years. Participants were randomized to receive 1 dose of mRNA-1345 (12.5, 25, 50, 100, or 200 µg) or placebo and matched mRNA-1345 booster or placebo at 12 months.Overall, 298 participants received the first injection and 247 received the 12-month booster injection. mRNA-1345 was generally well tolerated after both injections, with the most frequently reported solicited adverse reactions being injection site pain, fatigue, headache, arthralgia, and myalgia. Reactogenicity was higher after the booster injection but with severity, time to onset, and duration similar to the first injection. A single mRNA-1345 injection boosted RSV-A and RSV-B neutralizing antibody titers and prefusion F binding antibody (preF bAb) concentrations at 1 month (geometric mean fold rises: RSV-A, 10.2-16.5; RSV-B, 5.3-12.5; preF bAb, 7.2-12.1). RSV antibody levels remained above baseline through 12 months, indicating immune persistence. A 12-month booster injection also increased RSV-A and RSV-B neutralizing antibody titers and preF bAb concentrations; titers after booster injection were numerically lower than those after the first dose, with overlapping 95% CIs.RESULTSOverall, 298 participants received the first injection and 247 received the 12-month booster injection. mRNA-1345 was generally well tolerated after both injections, with the most frequently reported solicited adverse reactions being injection site pain, fatigue, headache, arthralgia, and myalgia. Reactogenicity was higher after the booster injection but with severity, time to onset, and duration similar to the first injection. A single mRNA-1345 injection boosted RSV-A and RSV-B neutralizing antibody titers and prefusion F binding antibody (preF bAb) concentrations at 1 month (geometric mean fold rises: RSV-A, 10.2-16.5; RSV-B, 5.3-12.5; preF bAb, 7.2-12.1). RSV antibody levels remained above baseline through 12 months, indicating immune persistence. A 12-month booster injection also increased RSV-A and RSV-B neutralizing antibody titers and preF bAb concentrations; titers after booster injection were numerically lower than those after the first dose, with overlapping 95% CIs.mRNA-1345 was well tolerated and immunogenic following a single injection and a 12-month booster.CONCLUSIONSmRNA-1345 was well tolerated and immunogenic following a single injection and a 12-month booster.NCT04528719 (ClinicalTrials.gov).CLINICAL TRIALS REGISTRATIONNCT04528719 (ClinicalTrials.gov). An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults. Based on a randomized, observer-blind, placebo-controlled design, this phase 1 dose-ranging study evaluated the safety, reactogenicity, and immunogenicity of mRNA-1345 in adults aged 65 to 79 years. Participants were randomized to receive 1 dose of mRNA-1345 (12.5, 25, 50, 100, or 200 µg) or placebo and matched mRNA-1345 booster or placebo at 12 months. Overall, 298 participants received the first injection and 247 received the 12-month booster injection. mRNA-1345 was generally well tolerated after both injections, with the most frequently reported solicited adverse reactions being injection site pain, fatigue, headache, arthralgia, and myalgia. Reactogenicity was higher after the booster injection but with severity, time to onset, and duration similar to the first injection. A single mRNA-1345 injection boosted RSV-A and RSV-B neutralizing antibody titers and prefusion F binding antibody (preF bAb) concentrations at 1 month (geometric mean fold rises: RSV-A, 10.2-16.5; RSV-B, 5.3-12.5; preF bAb, 7.2-12.1). RSV antibody levels remained above baseline through 12 months, indicating immune persistence. A 12-month booster injection also increased RSV-A and RSV-B neutralizing antibody titers and preF bAb concentrations; titers after booster injection were numerically lower than those after the first dose, with overlapping 95% CIs. mRNA-1345 was well tolerated and immunogenic following a single injection and a 12-month booster. NCT04528719 (ClinicalTrials.gov). |
| Author | Kapoor, Archana Das, Rituparna Harper, Charles Reuter, Caroline Wilson, Lauren Panozzo, Catherine A Stoszek, Sonia K Shaw, Christine A Mithani, Runa Dhar, Rakesh Guo, Ruiting Goswami, Jaya Chen, Grace L Wilson, Eleanor Simorellis, Alana K Essink, Brandon |
| Author_xml | – sequence: 1 givenname: Christine A surname: Shaw fullname: Shaw, Christine A – sequence: 2 givenname: Brandon surname: Essink fullname: Essink, Brandon – sequence: 3 givenname: Charles surname: Harper fullname: Harper, Charles – sequence: 4 givenname: Runa surname: Mithani fullname: Mithani, Runa – sequence: 5 givenname: Archana surname: Kapoor fullname: Kapoor, Archana – sequence: 6 givenname: Rakesh surname: Dhar fullname: Dhar, Rakesh – sequence: 7 givenname: Lauren surname: Wilson fullname: Wilson, Lauren – sequence: 8 givenname: Ruiting surname: Guo fullname: Guo, Ruiting – sequence: 9 givenname: Catherine A surname: Panozzo fullname: Panozzo, Catherine A – sequence: 10 givenname: Eleanor surname: Wilson fullname: Wilson, Eleanor – sequence: 11 givenname: Alana K surname: Simorellis fullname: Simorellis, Alana K – sequence: 12 givenname: Caroline surname: Reuter fullname: Reuter, Caroline – sequence: 13 givenname: Sonia K surname: Stoszek fullname: Stoszek, Sonia K – sequence: 14 givenname: Grace L surname: Chen fullname: Chen, Grace L – sequence: 15 givenname: Rituparna surname: Das fullname: Das, Rituparna – sequence: 16 givenname: Jaya surname: Goswami fullname: Goswami, Jaya email: jaya.goswami@modernatx.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38385566$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kcluwjAQhq2qVaHLtcfKx_aQ1o5jkxwBdUGiiwriGhl7AkaOTePkwBP0tWsE7WWWf76Zw_wX6NR5BwjdUPJAScEejau0CY8bI4Hk9AT1KWeDRAjKTlGfkDRNaF4UPXQRwoYQkjExOEc9lrOccyH66GcmK2h3WDqNJ3XdOb8CZ5SJkq-iiuuv92EykgE0_pot8EIqZRzgiVO208atsMQ0Td68a9d45H1oocHGRfVzHZcwxWNr4kFp8bwxMcbZK0jbrnf4w-oID3Vn23CFzippA1wf8yWaPz_Nx6_J9ONlMh5OE5Vx1iaKKE2BQsG5WjLGKh47IQRUqSZEgCIVZFKISnBdFNm-3HMyh9hnKbtEd4ez28Z_dxDasjZBgbXSge9CmRaMZANO8j16e0S7ZQ263Damls2u_PtdBO4PgO-2_1NKyr0v5cGX8ugL-wUx7IEF |
| CitedBy_id | crossref_primary_10_1016_j_vaccine_2025_127589 crossref_primary_10_1038_s41541_025_01181_2 crossref_primary_10_3390_vaccines13060569 crossref_primary_10_3390_vaccines13090979 crossref_primary_10_3724_zdxbyxb_2024_0709 crossref_primary_10_3389_fimmu_2025_1501275 crossref_primary_10_3390_microorganisms13081876 crossref_primary_10_1080_21645515_2025_2557676 crossref_primary_10_3390_vaccines12121418 crossref_primary_10_3390_vaccines12121317 crossref_primary_10_1002_mco2_70016 crossref_primary_10_1093_infdis_jiae316 crossref_primary_10_1099_jgv_0_002095 crossref_primary_10_3390_vaccines13020097 crossref_primary_10_7326_ANNALS_24_02701 crossref_primary_10_1080_25310429_2025_2451456 crossref_primary_10_1007_s40121_024_01079_x crossref_primary_10_1016_S1473_3099_24_00589_9 crossref_primary_10_3390_vaccines13080827 crossref_primary_10_1002_psp4_70041 crossref_primary_10_15585_mmwr_mm7332e1 crossref_primary_10_3390_vaccines13080882 crossref_primary_10_20517_microstructures_2024_172 crossref_primary_10_1038_s41467_025_61153_x crossref_primary_10_3389_bjbs_2025_14557 crossref_primary_10_3390_vaccines12121444 crossref_primary_10_3390_vaccines13030304 crossref_primary_10_3390_vaccines12050500 crossref_primary_10_3390_vaccines13010052 crossref_primary_10_1177_00185787241298140 crossref_primary_10_3390_vaccines12090980 crossref_primary_10_3390_microorganisms12112305 crossref_primary_10_1097_MCP_0000000000001151 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2024 The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. |
| Copyright_xml | – notice: The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2024 – notice: The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. |
| DBID | TOX CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1093/infdis/jiae081 |
| DatabaseName | Oxford Journals Open Access Collection Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: TOX name: Oxford Journals Open Access Collection url: https://academic.oup.com/journals/ sourceTypes: Publisher – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1537-6613 |
| EndPage | e656 |
| ExternalDocumentID | 38385566 10.1093/infdis/jiae081 |
| Genre | Randomized Controlled Trial Journal Article Clinical Trial, Phase I |
| GrantInformation_xml | – fundername: Moderna, Inc |
| GroupedDBID | --- -DZ -~X ..I .2P .55 .GJ .I3 .XZ .ZR 08P 0R~ 123 1KJ 1TH 29K 2AX 2WC 36B 3O- 4.4 41~ 48X 53G 5GY 5RE 5VS 5WD 6.Y 70D 85S AABZA AACGO AACZT AAHBH AAHTB AAJKP AAJQQ AAMVS AANCE AAOGV AAPGJ AAPNW AAPQZ AAPXW AAQQT AARHZ AAUAY AAUQX AAVAP AAWDT AAWTL AAYOK ABBHK ABEUO ABIXL ABJNI ABKDP ABLJU ABNHQ ABNKS ABOCM ABPEJ ABPLY ABPPZ ABPTD ABQLI ABQNK ABSAR ABSMQ ABTLG ABWST ABXSQ ABXVV ABZBJ ACFRR ACGFO ACGFS ACGOD ACMRT ACPQN ACPRK ACUFI ACUTJ ACUTO ACYHN ACZBC ADACV ADBBV ADEYI ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADULT ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKPW AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEUPB AEWNT AEXZC AFFNX AFFZL AFHKK AFIYH AFOFC AFSHK AFXAL AFXEN AFYAG AGINJ AGKEF AGKRT AGMDO AGQXC AGSYK AGUTN AHMBA AHXPO AI. AIAGR AIJHB AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APJGH APWMN AQDSO AQKUS AQVQM ATGXG AVNTJ AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BR6 BTRTY BVRKM BZKNY C45 CDBKE CS3 CZ4 D-I DAKXR DCCCD DIK DILTD DOOOF DU5 D~K EBS ECGQY EE~ EIHJH EJD EMOBN ENERS ESX F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK G8K GAUVT GJXCC GX1 H13 H5~ HAR HQ3 HTVGU HW0 HZ~ IH2 IOX IPSME J21 J5H JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KAQDR KBUDW KOP KQ8 KSI KSN L7B LSO LU7 M49 MBLQV MHKGH MJL ML0 MVM N4W N9A NEJ NGC NOMLY NOYVH NU- NVLIB O0~ O9- OAUYM OAWHX OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P0- P2P PAFKI PEELM PQQKQ Q1. Q5Y QBD RD5 ROX ROZ RUSNO RW1 RXO SA0 SJN TCURE TEORI TJX TMA TOX TR2 VH1 W2D W8F WH7 X7H X7M Y6R YAYTL YKOAZ YXANX ZE2 ZGI ZKG ZXP ~91 ABDFA ABEJV ABGNP ABPQP ABVGC ADNBA AEMQT AGORE AHGBF AHMMS AJBYB AJNCP ALXQX CGR CUY CVF ECM EIF JXSIZ NPM 7X8 |
| ID | FETCH-LOGICAL-c453t-c0cd1e1e955cb333f51e1666ef2d006ec0fe4a66f65d9944a66cb33a8e5d9423 |
| IEDL.DBID | TOX |
| ISICitedReferencesCount | 39 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001182648300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0022-1899 1537-6613 |
| IngestDate | Wed Oct 01 14:21:09 EDT 2025 Mon Jul 21 05:55:24 EDT 2025 Thu Oct 10 23:24:17 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | older adult safety and immunogenicity mRNA-1345 respiratory syncytial virus mRNA vaccine |
| Language | English |
| License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c453t-c0cd1e1e955cb333f51e1666ef2d006ec0fe4a66f65d9944a66cb33a8e5d9423 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://dx.doi.org/10.1093/infdis/jiae081 |
| PMID | 38385566 |
| PQID | 2930475082 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2930475082 pubmed_primary_38385566 oup_primary_10_1093_infdis_jiae081 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-Sep-23 |
| PublicationDateYYYYMMDD | 2024-09-23 |
| PublicationDate_xml | – month: 09 year: 2024 text: 2024-Sep-23 day: 23 |
| PublicationDecade | 2020 |
| PublicationPlace | US |
| PublicationPlace_xml | – name: US – name: United States |
| PublicationTitle | The Journal of infectious diseases |
| PublicationTitleAlternate | J Infect Dis |
| PublicationYear | 2024 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| SSID | ssj0004367 |
| Score | 2.5993173 |
| Snippet | Abstract
Background
An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older... An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults. Based on a... An mRNA-based respiratory syncytial virus (RSV) vaccine, mRNA-1345, is under clinical investigation to address RSV disease burden in older adults.BACKGROUNDAn... |
| SourceID | proquest pubmed oup |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | e647 |
| SubjectTerms | Aged Antibodies, Neutralizing - blood Antibodies, Viral - blood Female Humans Immunization, Secondary Immunogenicity, Vaccine Male mRNA Vaccines Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Vaccines - administration & dosage Respiratory Syncytial Virus Vaccines - adverse effects Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Virus, Human - genetics Respiratory Syncytial Virus, Human - immunology RNA, Messenger - genetics RNA, Messenger - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology |
| Title | Safety and Immunogenicity of an mRNA-Based RSV Vaccine Including a 12-Month Booster in a Phase 1 Clinical Trial in Healthy Older Adults |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38385566 https://www.proquest.com/docview/2930475082 |
| Volume | 230 |
| WOSCitedRecordID | wos001182648300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dT9swED9tiCFeGGMMygDdpr1aJHGcOo8tAsEDpYIK9S1y_KEWsQQ1KVL_Av5tzk3oJLYH9hLFdmxH95H7WZe7A_hlyCQL6QSzeRqwWBvHyAxrFsfacilTKVywLDbRHQzkeJwO22TR1T9c-Ck_IUqbaXVyP1U2WAZZh0J6iR5dj_9EQPKk-5oXPKQjxCo949vpb-LY_oKTS7Ny_vk_XmgbtlrsiL2G2V_ggy124FNTTXKxAxtXrZ_8KzzfKmfrBarC4KWPAClJTmiMukpHvfj7ZtBjfbJgBm9u7_BOaT8R6WvxMPfWDBWGESOFryfYL30gyAynBfUOJzQJQ2zziT7gyEuwH2sCmhZ47et-Y8_n9ah2YXR-Njq9YG3JBaZjwWumA21CG9pUCJ1zzp2gFp1wrIsM6afVgbOxShKXCJOmsb_1zylpqU3I7BusFWVh9wEjJXIT0kopaXwoA5VHMjG5lLk2Ua7yDvwkRmSPTU6NrPGF86yhbdbStgM_XvmUkdh7X4YqbDmvMkIpQUxoR0Yd2GsYuFqLDt1SEEw9eM8W32EzIpzifwGJ-CGs1bO5PYJ1_VRPq9kxfOyOJV0Hw6vjpcS9AGBE0bI |
| linkProvider | Oxford University Press |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Safety+and+Immunogenicity+of+an+mRNA-Based+RSV+Vaccine+Including+a+12-Month+Booster+in+a+Phase+1+Clinical+Trial+in+Healthy+Older+Adults&rft.jtitle=The+Journal+of+infectious+diseases&rft.au=Shaw%2C+Christine+A&rft.au=Essink%2C+Brandon&rft.au=Harper%2C+Charles&rft.au=Mithani%2C+Runa&rft.date=2024-09-23&rft.pub=Oxford+University+Press&rft.issn=0022-1899&rft.eissn=1537-6613&rft.volume=230&rft.issue=3&rft.spage=e647&rft.epage=e656&rft_id=info:doi/10.1093%2Finfdis%2Fjiae081&rft.externalDocID=10.1093%2Finfdis%2Fjiae081 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1899&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1899&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1899&client=summon |