Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice

Quercetin is a known antioxidant and protein kinase C (PKC) inhibitor. Previous studies have shown that mania involves oxidative stress and an increase in PKC activity. We hypothesized that quercetin affects manic symptoms. In the present study, manic-like behavior (hyperlocomotion) and oxidative st...

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Veröffentlicht in:	Free radical biology & medicine Jg. 99; S. 79 - 86
Hauptverfasser:	Kanazawa, Luiz K.S., Vecchia, Débora D., Wendler, Etiéli M., Hocayen, Palloma de A.S., dos Reis Lívero, Francislaine A., Stipp, Maria Carolina, Barcaro, Inara M.R., Acco, Alexandra, Andreatini, Roberto
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.10.2016
Schlagworte:	Animals Antimanic Agents - pharmacology Antioxidants - pharmacology Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - etiology Bipolar Disorder - metabolism Bipolar Disorder - physiopathology Corpus Striatum - drug effects Corpus Striatum - metabolism Disease Models, Animal Drug Administration Schedule Glutathione - agonists Glutathione - metabolism Hippocampus - drug effects Hippocampus - metabolism Lipid Peroxidation - drug effects Male Mania Mice Oxidative stress Oxidative Stress - drug effects Paradoxical sleep deprivation Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Protein kinase C Psychomotor Agitation - drug therapy Psychomotor Agitation - etiology Psychomotor Agitation - metabolism Psychomotor Agitation - physiopathology Quercetin Quercetin - pharmacology Sleep Deprivation - complications Sleep Deprivation - metabolism Sleep Deprivation - physiopathology PSD Oxidative stress BD Protein kinase C DPPH DTNB Paradoxical sleep deprivation CNS PKC SOD Bipolar disorder GSK-3 LPO PFC GPx CAT Quercetin CMC Mania GSH
ISSN:	0891-5849, 1873-4596, 1873-4596
Online-Zugang:	Volltext
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Zusammenfassung:	Quercetin is a known antioxidant and protein kinase C (PKC) inhibitor. Previous studies have shown that mania involves oxidative stress and an increase in PKC activity. We hypothesized that quercetin affects manic symptoms. In the present study, manic-like behavior (hyperlocomotion) and oxidative stress were induced by 24h paradoxical sleep deprivation (PSD) in male Swiss mice. Both 10 and 40mg/kg quercetin prevented PSD-induced hyperlocomotion. Quercetin reversed the PSD-induced decrease in glutathione (GSH) levels in the prefrontal cortex (PFC) and striatum. Quercetin also reversed the PSD-induced increase in lipid peroxidation (LPO) in the PFC, hippocampus, and striatum. Pearson's correlation analysis revealed a negative correlation between locomotor activity and GSH in the PFC in sleep-deprived mice and a positive correlation between locomotor activity and LPO in the PFC and striatum in sleep-deprived mice. These results suggest that quercetin exerts an antimanic-like effect at doses that do not impair spontaneous locomotor activity, and the antioxidant action of quercetin might contribute to its antimanic-like effects. •Quercetin blocked the hyperactivity induced by sleep deprivation.•Sleep deprivation increased oxidative stress.•Quercetin blocked sleep deprivation-induced oxidative stress.•There is a significant correlation between hyperactivity and oxidative stress.•Quercetin showed an antimanic-like effect probably related to its antioxidant action.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0891-5849 1873-4596 1873-4596
DOI:	10.1016/j.freeradbiomed.2016.07.027