Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice

Quercetin is a known antioxidant and protein kinase C (PKC) inhibitor. Previous studies have shown that mania involves oxidative stress and an increase in PKC activity. We hypothesized that quercetin affects manic symptoms. In the present study, manic-like behavior (hyperlocomotion) and oxidative st...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 99; pp. 79 - 86
Main Authors:	Kanazawa, Luiz K.S., Vecchia, Débora D., Wendler, Etiéli M., Hocayen, Palloma de A.S., dos Reis Lívero, Francislaine A., Stipp, Maria Carolina, Barcaro, Inara M.R., Acco, Alexandra, Andreatini, Roberto
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.10.2016
Subjects:	Animals Antimanic Agents - pharmacology Antioxidants - pharmacology Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - etiology Bipolar Disorder - metabolism Bipolar Disorder - physiopathology Corpus Striatum - drug effects Corpus Striatum - metabolism Disease Models, Animal Drug Administration Schedule Glutathione - agonists Glutathione - metabolism Hippocampus - drug effects Hippocampus - metabolism Lipid Peroxidation - drug effects Male Mania Mice Oxidative stress Oxidative Stress - drug effects Paradoxical sleep deprivation Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Protein kinase C Psychomotor Agitation - drug therapy Psychomotor Agitation - etiology Psychomotor Agitation - metabolism Psychomotor Agitation - physiopathology Quercetin Quercetin - pharmacology Sleep Deprivation - complications Sleep Deprivation - metabolism Sleep Deprivation - physiopathology PSD Oxidative stress BD Protein kinase C DPPH DTNB Paradoxical sleep deprivation CNS PKC SOD Bipolar disorder GSK-3 LPO PFC GPx CAT Quercetin CMC Mania GSH
ISSN:	0891-5849, 1873-4596, 1873-4596
Online Access:	Get full text
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