Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice

Quercetin is a known antioxidant and protein kinase C (PKC) inhibitor. Previous studies have shown that mania involves oxidative stress and an increase in PKC activity. We hypothesized that quercetin affects manic symptoms. In the present study, manic-like behavior (hyperlocomotion) and oxidative st...

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Published in:Free radical biology & medicine Vol. 99; pp. 79 - 86
Main Authors: Kanazawa, Luiz K.S., Vecchia, Débora D., Wendler, Etiéli M., Hocayen, Palloma de A.S., dos Reis Lívero, Francislaine A., Stipp, Maria Carolina, Barcaro, Inara M.R., Acco, Alexandra, Andreatini, Roberto
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.10.2016
Subjects:
Animals
Antimanic Agents - pharmacology
Antioxidants - pharmacology
Bipolar disorder
Bipolar Disorder - drug therapy
Bipolar Disorder - etiology
Bipolar Disorder - metabolism
Bipolar Disorder - physiopathology
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Disease Models, Animal
Drug Administration Schedule
Glutathione - agonists
Glutathione - metabolism
Hippocampus - drug effects
Hippocampus - metabolism
Lipid Peroxidation - drug effects
Male
Mania
Mice
Oxidative stress
Oxidative Stress - drug effects
Paradoxical sleep deprivation
Prefrontal Cortex - drug effects
Prefrontal Cortex - metabolism
Protein kinase C
Psychomotor Agitation - drug therapy
Psychomotor Agitation - etiology
Psychomotor Agitation - metabolism
Psychomotor Agitation - physiopathology
Quercetin
Quercetin - pharmacology
Sleep Deprivation - complications
Sleep Deprivation - metabolism
Sleep Deprivation - physiopathology
PSD
Oxidative stress
BD
Protein kinase C
DPPH
DTNB
Paradoxical sleep deprivation
CNS
PKC
SOD
Bipolar disorder
GSK-3
LPO
PFC
GPx
CAT
Quercetin
CMC
Mania
GSH
ISSN:0891-5849, 1873-4596, 1873-4596
Online Access:Get full text
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Summary:Quercetin is a known antioxidant and protein kinase C (PKC) inhibitor. Previous studies have shown that mania involves oxidative stress and an increase in PKC activity. We hypothesized that quercetin affects manic symptoms. In the present study, manic-like behavior (hyperlocomotion) and oxidative stress were induced by 24h paradoxical sleep deprivation (PSD) in male Swiss mice. Both 10 and 40mg/kg quercetin prevented PSD-induced hyperlocomotion. Quercetin reversed the PSD-induced decrease in glutathione (GSH) levels in the prefrontal cortex (PFC) and striatum. Quercetin also reversed the PSD-induced increase in lipid peroxidation (LPO) in the PFC, hippocampus, and striatum. Pearson's correlation analysis revealed a negative correlation between locomotor activity and GSH in the PFC in sleep-deprived mice and a positive correlation between locomotor activity and LPO in the PFC and striatum in sleep-deprived mice. These results suggest that quercetin exerts an antimanic-like effect at doses that do not impair spontaneous locomotor activity, and the antioxidant action of quercetin might contribute to its antimanic-like effects. •Quercetin blocked the hyperactivity induced by sleep deprivation.•Sleep deprivation increased oxidative stress.•Quercetin blocked sleep deprivation-induced oxidative stress.•There is a significant correlation between hyperactivity and oxidative stress.•Quercetin showed an antimanic-like effect probably related to its antioxidant action.
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ISSN:0891-5849
1873-4596
1873-4596
DOI:10.1016/j.freeradbiomed.2016.07.027