Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs

In guinea pigs, choroidal thickness (ChT) and choroidal blood perfusion (ChBP) simultaneously decrease in experimental myopia, and both increase during recovery. However, the causal relationship between ChBP and myopia requires further investigation. In this study, we examined the changes of ChBP wi...

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Published in:Investigative ophthalmology & visual science Vol. 61; no. 13; p. 25
Main Authors: Zhou, Xuan, Zhang, Sen, Zhang, Guoyun, Chen, Yizhong, Lei, Yi, Xiang, Jing, Xu, Renchang, Qu, Jia, Zhou, Xiangtian
Format: Journal Article
Language:English
Published: United States The Association for Research in Vision and Ophthalmology 19.11.2020
Subjects:
Adrenergic alpha-1 Receptor Antagonists - administration & dosage
Animals
Atropine - administration & dosage
Biometry
Choroid - blood supply
Disease Models, Animal
Guinea Pigs
Light
Muscarinic Antagonists - administration & dosage
Myopia - physiopathology
Myopia - prevention & control
Physiology and Pharmacology
Prazosin - administration & dosage
Refraction, Ocular
Regional Blood Flow - physiology
Sclera - blood supply
Sensory Deprivation
Tomography, Optical Coherence
ISSN:1552-5783, 0146-0404, 1552-5783
Online Access:Get full text
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Summary:In guinea pigs, choroidal thickness (ChT) and choroidal blood perfusion (ChBP) simultaneously decrease in experimental myopia, and both increase during recovery. However, the causal relationship between ChBP and myopia requires further investigation. In this study, we examined the changes of ChBP with three different antimyopia treatments. We also actively increased ChBP to examine the direct effect on myopia development in guinea pigs. Experiment 1: Guinea pigs wore occluders on the right eye for two weeks to induce form-deprivation myopia (FDM). Simultaneously they received daily antimyopia treatments: peribulbar injections of atropine or apomorphine or exposure to intense light. Experiment 2: The vasodilator prazosin was injected daily into the form-deprivation eyes to increase ChBP during the two-week induction of FDM. Other FDM animals received appropriate control treatments. Changes in refraction, axial length, ChBP, ChT, and hypoxia-labeled pimonidazole adducts in the sclera were measured. The antimyopia treatments atropine, apomorphine, and intense light all significantly inhibited myopia development and the decrease in ChBP. The treatments also reduced scleral hypoxia, as indicated by the decrease in hypoxic signals. Furthermore, actively increasing ChBP with prazosin inhibited the progression of myopia, as well as the increase in axial length and scleral hypoxia. Our data strongly indicate that increased ChBP attenuates scleral hypoxia, and thereby inhibits the development of myopia. Thus ChBP may be a promising target for myopia retardation. As such, it can serve as an immediate predictor of myopia development as well as a long-term marker of it.
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XZ and SZ contributed equally to the work presented here and should therefore be regarded as equivalent authors.
ISSN:1552-5783
0146-0404
1552-5783
DOI:10.1167/iovs.61.13.25