Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota

The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find tha...

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Published in:	Nature communications Vol. 4; no. 1; p. 2151
Main Authors:	Hu, Yongfei, Yang, Xi, Qin, Junjie, Lu, Na, Cheng, Gong, Wu, Na, Pan, Yuanlong, Li, Jing, Zhu, Liying, Wang, Xin, Meng, Zhiqi, Zhao, Fangqing, Liu, Di, Ma, Juncai, Qin, Nan, Xiang, Chunsheng, Xiao, Yonghong, Li, Lanjuan, Yang, Huanming, Wang, Jian, Yang, Ruifu, Gao, George F., Wang, Jun, Zhu, Baoli
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23.07.2013 Nature Publishing Group
Subjects:	631/208/212/2142 631/326/22/1434 692/308 692/698/2741/2135 Antibiotic resistance Asian Continental Ancestry Group Drug Resistance, Multiple, Bacterial - genetics European Continental Ancestry Group Gastrointestinal Tract - microbiology Genes, Bacterial Humanities and Social Sciences Humans Metagenome Microbiota - genetics multidisciplinary Multigene Family Phylogeny Science Science (multidisciplinary)
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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Abstract	The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota. The appearance of antibiotic resistance has been attributed to the misuse of antibiotics. By analysing the diversity of antibiotic resistance genes present in 162 human gut microbiota samples, the authors find that Chinese individuals harbour a larger pool of resistance genes than Spanish or Danish counterparts.
AbstractList	The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota. The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota. The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota. The appearance of antibiotic resistance has been attributed to the misuse of antibiotics. By analysing the diversity of antibiotic resistance genes present in 162 human gut microbiota samples, the authors find that Chinese individuals harbour a larger pool of resistance genes than Spanish or Danish counterparts.
ArticleNumber	2151
Author	Wang, Jian Cheng, Gong Hu, Yongfei Qin, Junjie Lu, Na Wang, Xin Xiang, Chunsheng Pan, Yuanlong Li, Jing Zhao, Fangqing Li, Lanjuan Wang, Jun Xiao, Yonghong Zhu, Liying Qin, Nan Gao, George F. Zhu, Baoli Meng, Zhiqi Liu, Di Ma, Juncai Yang, Xi Yang, Ruifu Wu, Na Yang, Huanming
Author_xml	– sequence: 1 givenname: Yongfei surname: Hu fullname: Hu, Yongfei organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 2 givenname: Xi surname: Yang fullname: Yang, Xi organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 3 givenname: Junjie surname: Qin fullname: Qin, Junjie organization: BGI-Shenzhen – sequence: 4 givenname: Na surname: Lu fullname: Lu, Na organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 5 givenname: Gong surname: Cheng fullname: Cheng, Gong organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 6 givenname: Na surname: Wu fullname: Wu, Na organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 7 givenname: Yuanlong surname: Pan fullname: Pan, Yuanlong organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 8 givenname: Jing surname: Li fullname: Li, Jing organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 9 givenname: Liying surname: Zhu fullname: Zhu, Liying organization: State Key Laboratory of Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences – sequence: 10 givenname: Xin surname: Wang fullname: Wang, Xin organization: State Key Laboratory of Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences – sequence: 11 givenname: Zhiqi surname: Meng fullname: Meng, Zhiqi organization: State Key Laboratory of Breeding Base for Zhejiang Sustainable Pest and Disease Control, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences – sequence: 12 givenname: Fangqing surname: Zhao fullname: Zhao, Fangqing organization: Computational Genomics Laboratory, Beijing Institutes of Life Science, Chinese Academy of Sciences – sequence: 13 givenname: Di surname: Liu fullname: Liu, Di organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 14 givenname: Juncai surname: Ma fullname: Ma, Juncai organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences – sequence: 15 givenname: Nan surname: Qin fullname: Qin, Nan organization: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University – sequence: 16 givenname: Chunsheng surname: Xiang fullname: Xiang, Chunsheng organization: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University – sequence: 17 givenname: Yonghong surname: Xiao fullname: Xiao, Yonghong organization: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University – sequence: 18 givenname: Lanjuan surname: Li fullname: Li, Lanjuan organization: State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University – sequence: 19 givenname: Huanming surname: Yang fullname: Yang, Huanming organization: BGI-Shenzhen – sequence: 20 givenname: Jian surname: Wang fullname: Wang, Jian organization: BGI-Shenzhen – sequence: 21 givenname: Ruifu surname: Yang fullname: Yang, Ruifu organization: State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology – sequence: 22 givenname: George F. surname: Gao fullname: Gao, George F. organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Research Network of Immunity and Health, Beijing Institutes of Life Science, Chinese Academy of Sciences – sequence: 23 givenname: Jun surname: Wang fullname: Wang, Jun organization: BGI-Shenzhen – sequence: 24 givenname: Baoli surname: Zhu fullname: Zhu, Baoli email: zhubaoli@im.ac.cn organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
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Snippet	The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse...
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SubjectTerms	631/208/212/2142 631/326/22/1434 692/308 692/698/2741/2135 Antibiotic resistance Asian Continental Ancestry Group Drug Resistance, Multiple, Bacterial - genetics European Continental Ancestry Group Gastrointestinal Tract - microbiology Genes, Bacterial Humanities and Social Sciences Humans Metagenome Microbiota - genetics multidisciplinary Multigene Family Phylogeny Science Science (multidisciplinary)
Title	Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota
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