Microhomology-mediated circular DNA formation from oligonucleosomal fragments during spermatogenesis

The landscape of extrachromosomal circular DNA (eccDNA) during mammalian spermatogenesis, as well as the biogenesis mechanism, remains to be explored. Here, we revealed widespread eccDNA formation in human sperms and mouse spermatogenesis. We noted that germline eccDNAs are derived from oligonucleos...

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Bibliographic Details
Published in:	eLife Vol. 12
Main Authors:	Hu, Jun, Zhang, Zhe, Xiao, Sai, Cao, Yalei, Chen, Yinghong, Weng, Jiaming, Jiang, Hui, Li, Wei, Chen, Jia-Yu, Liu, Chao
Format:	Journal Article
Language:	English
Published:	Cambridge eLife Sciences Publications Ltd 17.10.2023 eLife Sciences Publications, Ltd
Subjects:	Bioinformatics Biosynthesis Cell death Circular DNA Developmental Biology DNA fragmentation Euchromatin extrachromosomal circular DNA Genetics and Genomics Genomes Heterochromatin Meiosis microhomology Mitochondrial DNA Morphology Quality control Recombination hot spots Sperm Spermatogenesis
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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