Transcriptomic Signatures of Progression to Tuberculosis Disease Among Close Contacts in Brazil

Abstract Background Approximately 5% of people infected with Mycobacterium tuberculosis progress to tuberculosis (TB) disease without preventive therapy. There is a need for a prognostic test to identify those at highest risk of incident TB so that therapy can be targeted. We evaluated host blood tr...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 230; no. 6; pp. e1355 - e1365
Main Authors:	Mendelsohn, Simon C, Andrade, Bruno B, Mbandi, Stanley Kimbung, Andrade, Alice M S, Muwanga, Vanessa M, Figueiredo, Marina C, Erasmus, Mzwandile, Rolla, Valeria C, Thami, Prisca K, Cordeiro-Santos, Marcelo, Penn-Nicholson, Adam, Kritski, Afranio L, Hatherill, Mark, Sterling, Timothy R, Scriba, Thomas J
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 16.12.2024
Subjects:	Adolescent Adult Brazil - epidemiology Contact Tracing Disease Progression Female Gene Expression Profiling Humans Male Middle Aged Mycobacterium tuberculosis - genetics Prognosis Transcriptome Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - microbiology Young Adult Brazil prognostic transcriptomic blood biomarkers tuberculosis
ISSN:	0022-1899, 1537-6613, 1537-6613
Online Access:	Get full text
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