Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive protein in haemodialysis patients

Despite the well known association between interleukin-6 (IL-6) and cardiovascular mortality, no study has so far verified whether IL-6 adds prognostic information to that provided by C-reactive protein (CRP). A cohort of 218 haemodialysis patients from four different dialytic centres was followed-u...

Full description

Saved in:

Bibliographic Details
Published in:	Nephrology, dialysis, transplantation Vol. 19; no. 5; p. 1154
Main Authors:	Panichi, Vincenzo, Maggiore, Umberto, Taccola, Daniele, Migliori, Massimiliano, Rizza, Giovanni Manca, Consani, Cristina, Bertini, Alessio, Sposini, Stefano, Perez-Garcia, Rafael, Rindi, Paolo, Palla, Roberto, Tetta, Ciro
Format:	Journal Article
Language:	English
Published:	England 01.05.2004
Subjects:	Biomarkers - blood C-Reactive Protein - analysis Cardiovascular Diseases - mortality Cohort Studies Databases, Factual Female Humans Interleukin-6 - blood Male Middle Aged Predictive Value of Tests Renal Dialysis - mortality Reproducibility of Results Retrospective Studies
ISSN:	0931-0509
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Despite the well known association between interleukin-6 (IL-6) and cardiovascular mortality, no study has so far verified whether IL-6 adds prognostic information to that provided by C-reactive protein (CRP). A cohort of 218 haemodialysis patients from four different dialytic centres was followed-up retrospectively. Plasma IL-6 and CRP concentrations were determined. Full information on co-morbidities was available in 162 patients. With respect to the lowest quartile (< 3.6 pg/ml for IL-6, and < 2.2 mg/l for CRP), the crude relative risk (RR) of death from all causes of the upper quartile (> 13.9 pg/ml for IL-6, and > 12.8 mg/l for CRP) was 5.20 (95% confidence interval 2.06-13.011) for IL-6 and 3.16 (1.41-7.12) for CRP. When both variables were included, the estimates were 4.10 (1.30-12.96) for IL-6 and 1.29 (0.47-3.57) for CRP. As to continuous variables, the relationship between both variables and mortality tended to level off for the highest values, but became fairly linear after log transformation of the variables. For one unit SD of the log (variable), the RR was 2.09 (1.52-2.88) for IL-6 and 1.66 (1.23-2.24) for CRP. When they were included in the same model, the estimates were 1.90 (1.18-2.82) for IL-6 and 1.16 (0.81-1.66) for CRP. IL-6 has a stronger predictive value than CRP for cardiovascular mortality and provides independent prognostic information, while conveying most of that provided by CRP.
AbstractList	Despite the well known association between interleukin-6 (IL-6) and cardiovascular mortality, no study has so far verified whether IL-6 adds prognostic information to that provided by C-reactive protein (CRP).BACKGROUNDDespite the well known association between interleukin-6 (IL-6) and cardiovascular mortality, no study has so far verified whether IL-6 adds prognostic information to that provided by C-reactive protein (CRP).A cohort of 218 haemodialysis patients from four different dialytic centres was followed-up retrospectively. Plasma IL-6 and CRP concentrations were determined. Full information on co-morbidities was available in 162 patients.METHODSA cohort of 218 haemodialysis patients from four different dialytic centres was followed-up retrospectively. Plasma IL-6 and CRP concentrations were determined. Full information on co-morbidities was available in 162 patients.With respect to the lowest quartile (< 3.6 pg/ml for IL-6, and < 2.2 mg/l for CRP), the crude relative risk (RR) of death from all causes of the upper quartile (> 13.9 pg/ml for IL-6, and > 12.8 mg/l for CRP) was 5.20 (95% confidence interval 2.06-13.011) for IL-6 and 3.16 (1.41-7.12) for CRP. When both variables were included, the estimates were 4.10 (1.30-12.96) for IL-6 and 1.29 (0.47-3.57) for CRP. As to continuous variables, the relationship between both variables and mortality tended to level off for the highest values, but became fairly linear after log transformation of the variables. For one unit SD of the log (variable), the RR was 2.09 (1.52-2.88) for IL-6 and 1.66 (1.23-2.24) for CRP. When they were included in the same model, the estimates were 1.90 (1.18-2.82) for IL-6 and 1.16 (0.81-1.66) for CRP.RESULTSWith respect to the lowest quartile (< 3.6 pg/ml for IL-6, and < 2.2 mg/l for CRP), the crude relative risk (RR) of death from all causes of the upper quartile (> 13.9 pg/ml for IL-6, and > 12.8 mg/l for CRP) was 5.20 (95% confidence interval 2.06-13.011) for IL-6 and 3.16 (1.41-7.12) for CRP. When both variables were included, the estimates were 4.10 (1.30-12.96) for IL-6 and 1.29 (0.47-3.57) for CRP. As to continuous variables, the relationship between both variables and mortality tended to level off for the highest values, but became fairly linear after log transformation of the variables. For one unit SD of the log (variable), the RR was 2.09 (1.52-2.88) for IL-6 and 1.66 (1.23-2.24) for CRP. When they were included in the same model, the estimates were 1.90 (1.18-2.82) for IL-6 and 1.16 (0.81-1.66) for CRP.IL-6 has a stronger predictive value than CRP for cardiovascular mortality and provides independent prognostic information, while conveying most of that provided by CRP.CONCLUSIONSIL-6 has a stronger predictive value than CRP for cardiovascular mortality and provides independent prognostic information, while conveying most of that provided by CRP. Despite the well known association between interleukin-6 (IL-6) and cardiovascular mortality, no study has so far verified whether IL-6 adds prognostic information to that provided by C-reactive protein (CRP). A cohort of 218 haemodialysis patients from four different dialytic centres was followed-up retrospectively. Plasma IL-6 and CRP concentrations were determined. Full information on co-morbidities was available in 162 patients. With respect to the lowest quartile (< 3.6 pg/ml for IL-6, and < 2.2 mg/l for CRP), the crude relative risk (RR) of death from all causes of the upper quartile (> 13.9 pg/ml for IL-6, and > 12.8 mg/l for CRP) was 5.20 (95% confidence interval 2.06-13.011) for IL-6 and 3.16 (1.41-7.12) for CRP. When both variables were included, the estimates were 4.10 (1.30-12.96) for IL-6 and 1.29 (0.47-3.57) for CRP. As to continuous variables, the relationship between both variables and mortality tended to level off for the highest values, but became fairly linear after log transformation of the variables. For one unit SD of the log (variable), the RR was 2.09 (1.52-2.88) for IL-6 and 1.66 (1.23-2.24) for CRP. When they were included in the same model, the estimates were 1.90 (1.18-2.82) for IL-6 and 1.16 (0.81-1.66) for CRP. IL-6 has a stronger predictive value than CRP for cardiovascular mortality and provides independent prognostic information, while conveying most of that provided by CRP.
Author	Rizza, Giovanni Manca Palla, Roberto Bertini, Alessio Panichi, Vincenzo Maggiore, Umberto Tetta, Ciro Sposini, Stefano Taccola, Daniele Perez-Garcia, Rafael Rindi, Paolo Migliori, Massimiliano Consani, Cristina
Author_xml	– sequence: 1 givenname: Vincenzo surname: Panichi fullname: Panichi, Vincenzo organization: Department of Internal Medicine, University of Pisa, Italy – sequence: 2 givenname: Umberto surname: Maggiore fullname: Maggiore, Umberto – sequence: 3 givenname: Daniele surname: Taccola fullname: Taccola, Daniele – sequence: 4 givenname: Massimiliano surname: Migliori fullname: Migliori, Massimiliano – sequence: 5 givenname: Giovanni Manca surname: Rizza fullname: Rizza, Giovanni Manca – sequence: 6 givenname: Cristina surname: Consani fullname: Consani, Cristina – sequence: 7 givenname: Alessio surname: Bertini fullname: Bertini, Alessio – sequence: 8 givenname: Stefano surname: Sposini fullname: Sposini, Stefano – sequence: 9 givenname: Rafael surname: Perez-Garcia fullname: Perez-Garcia, Rafael – sequence: 10 givenname: Paolo surname: Rindi fullname: Rindi, Paolo – sequence: 11 givenname: Roberto surname: Palla fullname: Palla, Roberto – sequence: 12 givenname: Ciro surname: Tetta fullname: Tetta, Ciro
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/14993508$$D View this record in MEDLINE/PubMed
BookMark	eNo1UEtPwzAMzmGIPeDCD0A5cStz2qZtjmjiJU3iAufKTd0t0CYjSSftwH-nEkOyZPl7-LO8ZDPrLDF2I-BegMrWto3rXbcHmc7YYgJEAhLUnC1D-AQAlZblJZuLXKlMQrVgP682ku9p_DI2KbgJHHmI3tkdeX7w1Bodneeu49FF7Dnalmv0rXFHDHrs0fPB-Ykx8cTjHi3fJJ5QR3Okye8iGcun2iMNrjXYn8KUccBoyMZwxS467ANdn_uKfTw9vm9eku3b8-vmYZvoXGYxKVE2ShcdSpVTleW5lm2T6kohFFUBOi2wEVUnM4BqmlQBVQsomjwlXQIU6Yrd_e2dLvoeKcR6MEFT36MlN4a6FJUUUmST8PYsHJuB2vrgzYD-VP8_LP0F_rxu-A
CitedBy_id	crossref_primary_10_3390_nu10040397 crossref_primary_10_1016_j_molimm_2016_11_005 crossref_primary_10_1016_j_arcmed_2013_10_014 crossref_primary_10_1186_s12950_025_00442_0 crossref_primary_10_1097_MNH_0b013e32835846e3 crossref_primary_10_1111_j_1365_2362_2008_02050_x crossref_primary_10_2215_CJN_01650211 crossref_primary_10_1053_j_ajkd_2008_09_018 crossref_primary_10_1186_s41100_019_0202_2 crossref_primary_10_1007_s11010_018_3268_1 crossref_primary_10_1097_MAT_0000000000001541 crossref_primary_10_1111_j_1525_1594_2010_01000_x crossref_primary_10_1016_j_trim_2024_102043 crossref_primary_10_1093_ndt_gfp325 crossref_primary_10_1053_j_ajkd_2005_09_014 crossref_primary_10_1111_hdi_12178 crossref_primary_10_1080_00365510701408558 crossref_primary_10_2337_dc05_2385 crossref_primary_10_1016_j_nut_2014_06_012 crossref_primary_10_1093_ndt_gfl005 crossref_primary_10_1159_000369957 crossref_primary_10_1007_s10534_011_9409_6 crossref_primary_10_1111_j_1525_139X_2006_00138_x crossref_primary_10_1016_j_atherosclerosis_2011_10_038 crossref_primary_10_1007_s10157_016_1230_7 crossref_primary_10_1080_00365510601045088 crossref_primary_10_1111_hdi_12200 crossref_primary_10_1111_prd_12299 crossref_primary_10_1186_s12882_020_01812_x crossref_primary_10_2119_molmed_2008_00109 crossref_primary_10_1093_ndt_gfq802 crossref_primary_10_1111_hdi_12565 crossref_primary_10_1111_j_1399_0039_2009_01276_x crossref_primary_10_1016_j_nut_2013_08_017 crossref_primary_10_1038_sj_ki_5000382 crossref_primary_10_1053_j_jrn_2011_10_021 crossref_primary_10_1093_ndt_gfu233 crossref_primary_10_4103_jcvs_jcvs_4_22 crossref_primary_10_1093_ndt_gfr767 crossref_primary_10_1007_s40620_020_00943_6 crossref_primary_10_1093_ndt_gfq557 crossref_primary_10_1007_s11255_012_0271_4 crossref_primary_10_2215_CJN_01770211 crossref_primary_10_6061_clinics_2020_e1801 crossref_primary_10_1007_s40620_024_01956_1 crossref_primary_10_1093_ndt_gfp625 crossref_primary_10_1111_eci_12674 crossref_primary_10_5937_jomb0_25120 crossref_primary_10_2215_CJN_10400915 crossref_primary_10_1016_j_bbamcr_2023_119540 crossref_primary_10_1080_08860220802406385 crossref_primary_10_1093_ndt_gft495 crossref_primary_10_1016_j_semnephrol_2014_02_008 crossref_primary_10_1111_j_1525_139X_2005_18317_x crossref_primary_10_1111_j_1440_1797_2008_01021_x crossref_primary_10_1002_cbdv_202000956 crossref_primary_10_1177_089686080702702s38 crossref_primary_10_3390_jpm12071122 crossref_primary_10_1007_s00596_010_0186_y crossref_primary_10_5402_2012_986795 crossref_primary_10_18632_oncotarget_5084 crossref_primary_10_1007_s11255_013_0436_9 crossref_primary_10_1016_j_ijcard_2015_03_041 crossref_primary_10_3747_pdi_2010_00019 crossref_primary_10_1038_nrneph_2011_2 crossref_primary_10_1111_j_1365_2362_2008_02056_x crossref_primary_10_1111_sdi_13168 crossref_primary_10_1038_nrneph_2011_170 crossref_primary_10_2215_CJN_04980512 crossref_primary_10_3892_etm_2021_9693 crossref_primary_10_1053_j_ajkd_2006_06_005 crossref_primary_10_3747_pdi_2009_00092 crossref_primary_10_2215_CJN_02420409 crossref_primary_10_3109_0886022X_2012_696469 crossref_primary_10_1038_sj_ki_5002250 crossref_primary_10_3390_ijms20236008 crossref_primary_10_5301_ijao_5000411 crossref_primary_10_1016_j_humimm_2021_11_003 crossref_primary_10_1053_j_jrn_2017_11_001 crossref_primary_10_3389_fcimb_2019_00220 crossref_primary_10_1016_j_mvr_2020_104123 crossref_primary_10_1089_jir_2012_0109 crossref_primary_10_2119_2007_00107_Bruchfeld crossref_primary_10_1016_j_molimm_2021_02_024 crossref_primary_10_1093_ndt_gfu409 crossref_primary_10_1007_s00467_006_0359_0 crossref_primary_10_1155_2013_726178 crossref_primary_10_1177_039139880703001112 crossref_primary_10_1016_j_clnu_2022_02_013 crossref_primary_10_1007_s11255_020_02461_7 crossref_primary_10_1007_s10047_011_0561_0 crossref_primary_10_1080_08860220601039098 crossref_primary_10_1155_2017_1070959 crossref_primary_10_1053_j_ajkd_2009_02_008 crossref_primary_10_1053_j_ackd_2005_07_005 crossref_primary_10_1371_journal_pone_0172490 crossref_primary_10_1093_ndt_gfp141 crossref_primary_10_1007_s10554_017_1098_y crossref_primary_10_1016_j_kint_2017_07_010 crossref_primary_10_1093_ndt_gfs255 crossref_primary_10_1007_s11255_014_0878_8 crossref_primary_10_1016_j_jacc_2008_07_051 crossref_primary_10_1053_j_ajkd_2010_03_020 crossref_primary_10_1177_1721727X1301100108 crossref_primary_10_1159_000530808 crossref_primary_10_3747_pdi_2011_00326 crossref_primary_10_4103_jrms_JRMS_282_15 crossref_primary_10_1093_ndt_gfm951 crossref_primary_10_1111_j_1440_1797_2006_00541_x crossref_primary_10_1038_s41598_021_88655_0 crossref_primary_10_1371_journal_pone_0122073 crossref_primary_10_1016_j_ejmhg_2013_04_001 crossref_primary_10_1038_ni_3153 crossref_primary_10_3390_ijms18122580 crossref_primary_10_3390_nu15040860 crossref_primary_10_1111_j_1542_4758_2009_00352_x crossref_primary_10_1016_j_biopha_2007_03_002 crossref_primary_10_1038_sj_gene_6364330 crossref_primary_10_1016_j_cyto_2021_155684 crossref_primary_10_1111_j_1365_2796_2005_01516_x crossref_primary_10_1007_s40620_013_0033_0 crossref_primary_10_4103_heartviews_heartviews_118_24 crossref_primary_10_1016_S1561_5413_09_60224_6 crossref_primary_10_1681_ASN_2009040451 crossref_primary_10_3390_cancers13081824 crossref_primary_10_1016_j_nephro_2006_04_004 crossref_primary_10_1093_ndt_gfs128 crossref_primary_10_1155_2023_7154172 crossref_primary_10_1177_089686080602600104 crossref_primary_10_1093_ndt_gfi189 crossref_primary_10_1111_j_1365_277X_2010_01064_x crossref_primary_10_1016_j_semnephrol_2011_11_006 crossref_primary_10_1093_ndt_gfi224 crossref_primary_10_1016_j_arr_2025_102880 crossref_primary_10_1155_2015_898192
ContentType	Journal Article
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1093/ndt/gfh052
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
ExternalDocumentID	14993508
Genre	Multicenter Study Journal Article Comparative Study
GroupedDBID	--- -E4 .2P .55 .GJ .I3 .XZ .ZR 0R~ 123 18M 1TH 29M 2WC 4.4 482 48X 53G 5RE 5VS 5WA 5WD 6.Y 70D AABZA AACZT AAHTB AAJKP AAJQQ AAMDB AAMVS AAOGV AAPGJ AAPNW AAPQZ AAPXW AARHZ AAUAY AAUQX AAVAP AAWDT ABDFA ABEJV ABEUO ABGNP ABIXL ABKDP ABNGD ABNHQ ABNKS ABOCM ABPEJ ABPTD ABQLI ABQNK ABQTQ ABSAR ABSMQ ABVGC ABWST ABXVV ABZBJ ACFRR ACGFO ACGFS ACPQN ACPRK ACUFI ACUTJ ACUTO ACYHN ACZBC ADBBV ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEHUL AEJOX AEKPW AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFQV AFFZL AFIYH AFOFC AFSHK AFXAL AFXEN AFYAG AGINJ AGKEF AGKRT AGMDO AGQXC AGSYK AGUTN AHMBA AHMMS AHXPO AIAGR AIJHB AJEEA AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APJGH APWMN AQDSO AQKUS ASPBG ATGXG ATTQO AVWKF AXUDD AZFZN BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM BZKNY C45 CAG CDBKE CGR COF CS3 CUY CVF CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS ECM EE~ EIF EIHJH EJD ENERS F5P F9B FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HVGLF HW0 HZ~ IOX J21 JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN M-Z M49 MBLQV MHKGH ML0 N9A NGC NOMLY NOYVH NPM NTWIH NU- NVLIB O0~ O9- OAUYM OAWHX OCZFY ODMLO OHH OJQWA OJZSN OK1 OPAEJ OVD OWPYF O~Y P2P P6G PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD R44 RD5 RNI ROL ROX ROZ RUSNO RW1 RXO RZF RZO SDH TCURE TEORI TJX TMA TR2 W8F WH7 WOQ X7H X7M YAYTL YKOAZ YXANX ZGI ZKX ZXP ~91 7X8 ABPQP ACUKT ADNBA AEMQT AGQPQ AJBYB AJNCP ALXQX
ID	FETCH-LOGICAL-c453t-7a5b9c6fa594e8344c5db2c89a06860c26ab18f530080c29608d0a1b42ec70062
IEDL.DBID	7X8
ISICitedReferencesCount	167
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000221411200021&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0931-0509
IngestDate	Sun Sep 28 03:04:07 EDT 2025 Wed Feb 19 01:38:07 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c453t-7a5b9c6fa594e8344c5db2c89a06860c26ab18f530080c29608d0a1b42ec70062
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
OpenAccessLink	https://academic.oup.com/ndt/article-pdf/19/5/1154/5111577/gfh052.pdf
PMID	14993508
PQID	71851513
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_71851513 pubmed_primary_14993508
PublicationCentury	2000
PublicationDate	2004-05-01
PublicationDateYYYYMMDD	2004-05-01
PublicationDate_xml	– month: 05 year: 2004 text: 2004-05-01 day: 01
PublicationDecade	2000
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Nephrology, dialysis, transplantation
PublicationTitleAlternate	Nephrol Dial Transplant
PublicationYear	2004
SSID	ssj0009277
Score	2.1937122
Snippet	Despite the well known association between interleukin-6 (IL-6) and cardiovascular mortality, no study has so far verified whether IL-6 adds prognostic...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	1154
SubjectTerms	Biomarkers - blood C-Reactive Protein - analysis Cardiovascular Diseases - mortality Cohort Studies Databases, Factual Female Humans Interleukin-6 - blood Male Middle Aged Predictive Value of Tests Renal Dialysis - mortality Reproducibility of Results Retrospective Studies
Title	Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive protein in haemodialysis patients
URI	https://www.ncbi.nlm.nih.gov/pubmed/14993508 https://www.proquest.com/docview/71851513
Volume	19
WOSCitedRecordID	wos000221411200021&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1JS8NAFB6qFfHivtR1Dl6HNltnBgSRYvHS0oNCb2W2tEWb1Kb15n_3vWmCeBAPQghzSCDMvLz3vfUj5JYLzaXiAUuDiLNYuIRJrSSslHRaWy1c6skmeL8vhkM5qJG7qhcGyyornegVtc0NxsiboEPB9AbR_fydIWcU5lZLAo0NUo8AyGBBFx9-zwqXoeddBJcdHGawi9VwUhk1M7tsjtNJC9uNfgOW3sB09_73aftktwSW9GEtCQek5rJDst0rU-dH5NPH_t7c6nWasTadFlTRAuPgY7eg8wU-B-43zVO6zAGQU5VZan4Uq9KZh-oA2ynG22mHAeD06pL6aQ_TjMI1UW6WYzcKjjqh5djW4pi8dB-fO0-s5F5gJk6iJeMq0dK0U5XI2CEXh0msDo2QCntKWiZsKx2INIkQcpoQ_CBhWyrQcegMx8bME7KZ5Zk7IxRAiA21dqFFjSGtclFbq1Rx5WAlRIPcVNs6AtnGhIXKXL4qRtXGNsjp-mRG8_UIDnBYAFcBtjz_890LsrMutsEaxUtST-Gvdldky3wsp8Xi2osM3PuD3hf36c-f
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-6+is+a+stronger+predictor+of+total+and+cardiovascular+mortality+than+C-reactive+protein+in+haemodialysis+patients&rft.jtitle=Nephrology%2C+dialysis%2C+transplantation&rft.au=Panichi%2C+Vincenzo&rft.au=Maggiore%2C+Umberto&rft.au=Taccola%2C+Daniele&rft.au=Migliori%2C+Massimiliano&rft.date=2004-05-01&rft.issn=0931-0509&rft.volume=19&rft.issue=5&rft.spage=1154&rft_id=info:doi/10.1093%2Fndt%2Fgfh052&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0931-0509&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0931-0509&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0931-0509&client=summon