Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity

Inhibiting VEGF improves adult retino/choroido-vascular diseases, but can lead to recurrent intravitreous neovascularization (IVNV), avascular retina (AVA), and retinal detachment in preterm infants with retinopathy of prematurity (ROP). We sought to understand causes of late-onset IVNV and AVA foll...

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Bibliographic Details
Published in:	Investigative ophthalmology & visual science Vol. 54; no. 3; p. 2020
Main Authors:	McCloskey, Manabu, Wang, Haibo, Jiang, Yanchao, Smith, George Wesley, Strange, Jeremy, Hartnett, M Elizabeth
Format:	Journal Article
Language:	English
Published:	United States 21.03.2013
Subjects:	Animals Antibodies - pharmacology Biomarkers - metabolism Blotting, Western Body Weight - drug effects Case-Control Studies Disease Models, Animal Erythropoietin - metabolism Humans Infant, Newborn Neovascularization, Pathologic - chemically induced Rats Rats, Sprague-Dawley Retina - drug effects Retinopathy of Prematurity - drug therapy STAT3 Transcription Factor - metabolism Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor Receptor-2 - metabolism
ISSN:	1552-5783, 1552-5783
Online Access:	Get more information
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