Anti-VEGF antibody leads to later atypical intravitreous neovascularization and activation of angiogenic pathways in a rat model of retinopathy of prematurity

Inhibiting VEGF improves adult retino/choroido-vascular diseases, but can lead to recurrent intravitreous neovascularization (IVNV), avascular retina (AVA), and retinal detachment in preterm infants with retinopathy of prematurity (ROP). We sought to understand causes of late-onset IVNV and AVA foll...

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Veröffentlicht in:	Investigative ophthalmology & visual science Jg. 54; H. 3; S. 2020
Hauptverfasser:	McCloskey, Manabu, Wang, Haibo, Jiang, Yanchao, Smith, George Wesley, Strange, Jeremy, Hartnett, M Elizabeth
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.03.2013
Schlagworte:	Animals Antibodies - pharmacology Biomarkers - metabolism Blotting, Western Body Weight - drug effects Case-Control Studies Disease Models, Animal Erythropoietin - metabolism Humans Infant, Newborn Neovascularization, Pathologic - chemically induced Rats Rats, Sprague-Dawley Retina - drug effects Retinopathy of Prematurity - drug therapy STAT3 Transcription Factor - metabolism Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor Receptor-2 - metabolism
ISSN:	1552-5783, 1552-5783
Online-Zugang:	Weitere Angaben
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