Unlocking cellular plasticity: enhancing human iPSC reprogramming through bromodomain inhibition and extracellular matrix gene expression regulation

The transformation from a fibroblast mesenchymal cell state to an epithelial-like state is critical for induced pluripotent stem cell (iPSC) reprogramming. In this report, we describe studies with PFI-3, a small-molecule inhibitor that specifically targets the bromodomains of SMARCA2/4 and PBRM1 sub...

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Vydáno v:	Stem cells (Dayton, Ohio) Ročník 42; číslo 8; s. 706
Hlavní autoři:	Yang, Jun, Kinyamu, H Karimi, Ward, James M, Scappini, Erica, Muse, Ginger, Archer, Trevor K
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.08.2024
Témata:	Cell Plasticity - drug effects Cell Plasticity - genetics Cellular Reprogramming - drug effects Cellular Reprogramming - genetics Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Extracellular Matrix - metabolism Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Regulation - drug effects Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Transcription Factors - genetics Transcription Factors - metabolism PFI-3 reprogramming efficiency SWI/SNF iPSC cellular plasticity bromodomain inhibitor MET extracellular matrix
ISSN:	1549-4918, 1549-4918
On-line přístup:	Zjistit podrobnosti o přístupu
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