Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)

Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a "synthetic-metabolic" approach, involving two FDA-approved antibiotics and a dietary vitamin supplement. This approach was designed to induce a "rho-zero-like" phenotype in cancer cells. This strategy...

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Bibliographic Details
Published in:	Aging (Albany, NY.) Vol. 11; no. 8; p. 2202
Main Authors:	Fiorillo, Marco, Tóth, Fanni, Sotgia, Federica, Lisanti, Michael P
Format:	Journal Article
Language:	English
Published:	United States 19.04.2019
Subjects:	Anti-Bacterial Agents - pharmacology Ascorbic Acid - pharmacology Azithromycin - pharmacology Cell Proliferation - drug effects Cell Survival - drug effects Doxycycline - pharmacology Humans MCF-7 Cells Mitochondria - drug effects Mitochondria - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Organelle Biogenesis combination therapy mitochondrial ATP depletion Azithromycin Doxycycline Vitamin C glycolysis
ISSN:	1945-4589, 1945-4589
Online Access:	Get more information
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