Evaluation of genotoxicity induced by exposure to antineoplastic drugs in lymphocytes of oncology nurses and pharmacists
ABSTRACT The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs w...
Uloženo v:
| Vydáno v: | Journal of applied toxicology Ročník 33; číslo 3; s. 196 - 201 |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Blackwell Publishing Ltd
01.03.2013
Wiley Subscription Services, Inc |
| Témata: | |
| ISSN: | 0260-437X, 1099-1263, 1099-1263 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | ABSTRACT
The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs with biological structures vary according to the drug(s) and the individual's genetic susceptibility. This study was carried out to evaluate the genome damage induced by exposure to antineoplastic drugs in nurses (n = 20) and pharmacists (n = 18) working in the Oncology Department of Tanta Cancer Center. Thirty subjects matched in age, gender and smoking habit were selected as controls. Both chromosomal aberration analysis and micronucleus assay were used to evaluate genome damage in peripheral blood lymphocytes of the study subjects. The numbers of aberrant lymphocytes, as well as chromosomal aberration and micronuclei frequencies, were significantly increased in exposed personnel in comparison to matched controls. Compared with pharmacists, nurses showed notably higher level of chromosome damage. On the other hand, no significant difference in micronuclei frequency was observed between nurses and pharmacists. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The results of this study confirmed that handling antineoplastic drugs without appropriate precautions imposed a genotoxic risk for exposed healthcare workers. These results address the need for regular biomonitoring of exposed personnel. In addition, they call attention to the need for proper implementation of intervention measures aiming to eliminate or significantly reduce worker exposure and prevent untoward biological effects. Copyright © 2011 John Wiley & Sons, Ltd.
Pharmacists and nurses handling antineoplastic drugs showed significantly increased chromosomal aberration and micronuclei frequencies. Compared with pharmacists, nurses showed notably higher levels of chromosome damage, but not micronuclei frequency. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. |
|---|---|
| AbstractList | The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs with biological structures vary according to the drug(s) and the individual's genetic susceptibility. This study was carried out to evaluate the genome damage induced by exposure to antineoplastic drugs in nurses (n=20) and pharmacists (n=18) working in the Oncology Department of Tanta Cancer Center. Thirty subjects matched in age, gender and smoking habit were selected as controls. Both chromosomal aberration analysis and micronucleus assay were used to evaluate genome damage in peripheral blood lymphocytes of the study subjects. The numbers of aberrant lymphocytes, as well as chromosomal aberration and micronuclei frequencies, were significantly increased in exposed personnel in comparison to matched controls. Compared with pharmacists, nurses showed notably higher level of chromosome damage. On the other hand, no significant difference in micronuclei frequency was observed between nurses and pharmacists. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The results of this study confirmed that handling antineoplastic drugs without appropriate precautions imposed a genotoxic risk for exposed healthcare workers. These results address the need for regular biomonitoring of exposed personnel. In addition, they call attention to the need for proper implementation of intervention measures aiming to eliminate or significantly reduce worker exposure and prevent untoward biological effects. Copyright © 2011 John Wiley & Sons, Ltd. Pharmacists and nurses handling antineoplastic drugs showed significantly increased chromosomal aberration and micronuclei frequencies. Compared with pharmacists, nurses showed notably higher levels of chromosome damage, but not micronuclei frequency. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. [PUBLICATION ABSTRACT] The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs with biological structures vary according to the drug(s) and the individual's genetic susceptibility. This study was carried out to evaluate the genome damage induced by exposure to antineoplastic drugs in nurses (n = 20) and pharmacists (n = 18) working in the Oncology Department of Tanta Cancer Center. Thirty subjects matched in age, gender and smoking habit were selected as controls. Both chromosomal aberration analysis and micronucleus assay were used to evaluate genome damage in peripheral blood lymphocytes of the study subjects. The numbers of aberrant lymphocytes, as well as chromosomal aberration and micronuclei frequencies, were significantly increased in exposed personnel in comparison to matched controls. Compared with pharmacists, nurses showed notably higher level of chromosome damage. On the other hand, no significant difference in micronuclei frequency was observed between nurses and pharmacists. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The results of this study confirmed that handling antineoplastic drugs without appropriate precautions imposed a genotoxic risk for exposed healthcare workers. These results address the need for regular biomonitoring of exposed personnel. In addition, they call attention to the need for proper implementation of intervention measures aiming to eliminate or significantly reduce worker exposure and prevent untoward biological effects.The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs with biological structures vary according to the drug(s) and the individual's genetic susceptibility. This study was carried out to evaluate the genome damage induced by exposure to antineoplastic drugs in nurses (n = 20) and pharmacists (n = 18) working in the Oncology Department of Tanta Cancer Center. Thirty subjects matched in age, gender and smoking habit were selected as controls. Both chromosomal aberration analysis and micronucleus assay were used to evaluate genome damage in peripheral blood lymphocytes of the study subjects. The numbers of aberrant lymphocytes, as well as chromosomal aberration and micronuclei frequencies, were significantly increased in exposed personnel in comparison to matched controls. Compared with pharmacists, nurses showed notably higher level of chromosome damage. On the other hand, no significant difference in micronuclei frequency was observed between nurses and pharmacists. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The results of this study confirmed that handling antineoplastic drugs without appropriate precautions imposed a genotoxic risk for exposed healthcare workers. These results address the need for regular biomonitoring of exposed personnel. In addition, they call attention to the need for proper implementation of intervention measures aiming to eliminate or significantly reduce worker exposure and prevent untoward biological effects. The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs with biological structures vary according to the drug(s) and the individual's genetic susceptibility. This study was carried out to evaluate the genome damage induced by exposure to antineoplastic drugs in nurses ( n = 20) and pharmacists ( n = 18) working in the Oncology Department of Tanta Cancer Center. Thirty subjects matched in age, gender and smoking habit were selected as controls. Both chromosomal aberration analysis and micronucleus assay were used to evaluate genome damage in peripheral blood lymphocytes of the study subjects. The numbers of aberrant lymphocytes, as well as chromosomal aberration and micronuclei frequencies, were significantly increased in exposed personnel in comparison to matched controls. Compared with pharmacists, nurses showed notably higher level of chromosome damage. On the other hand, no significant difference in micronuclei frequency was observed between nurses and pharmacists. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The results of this study confirmed that handling antineoplastic drugs without appropriate precautions imposed a genotoxic risk for exposed healthcare workers. These results address the need for regular biomonitoring of exposed personnel. In addition, they call attention to the need for proper implementation of intervention measures aiming to eliminate or significantly reduce worker exposure and prevent untoward biological effects. Copyright © 2011 John Wiley & Sons, Ltd. Pharmacists and nurses handling antineoplastic drugs showed significantly increased chromosomal aberration and micronuclei frequencies. Compared with pharmacists, nurses showed notably higher levels of chromosome damage, but not micronuclei frequency. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. ABSTRACT The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs with biological structures vary according to the drug(s) and the individual's genetic susceptibility. This study was carried out to evaluate the genome damage induced by exposure to antineoplastic drugs in nurses (n = 20) and pharmacists (n = 18) working in the Oncology Department of Tanta Cancer Center. Thirty subjects matched in age, gender and smoking habit were selected as controls. Both chromosomal aberration analysis and micronucleus assay were used to evaluate genome damage in peripheral blood lymphocytes of the study subjects. The numbers of aberrant lymphocytes, as well as chromosomal aberration and micronuclei frequencies, were significantly increased in exposed personnel in comparison to matched controls. Compared with pharmacists, nurses showed notably higher level of chromosome damage. On the other hand, no significant difference in micronuclei frequency was observed between nurses and pharmacists. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The results of this study confirmed that handling antineoplastic drugs without appropriate precautions imposed a genotoxic risk for exposed healthcare workers. These results address the need for regular biomonitoring of exposed personnel. In addition, they call attention to the need for proper implementation of intervention measures aiming to eliminate or significantly reduce worker exposure and prevent untoward biological effects. Copyright © 2011 John Wiley & Sons, Ltd. Pharmacists and nurses handling antineoplastic drugs showed significantly increased chromosomal aberration and micronuclei frequencies. Compared with pharmacists, nurses showed notably higher levels of chromosome damage, but not micronuclei frequency. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs with biological structures vary according to the drug(s) and the individual's genetic susceptibility. This study was carried out to evaluate the genome damage induced by exposure to antineoplastic drugs in nurses (n=20) and pharmacists (n=18) working in the Oncology Department of Tanta Cancer Center. Thirty subjects matched in age, gender and smoking habit were selected as controls. Both chromosomal aberration analysis and micronucleus assay were used to evaluate genome damage in peripheral blood lymphocytes of the study subjects. The numbers of aberrant lymphocytes, as well as chromosomal aberration and micronuclei frequencies, were significantly increased in exposed personnel in comparison to matched controls. Compared with pharmacists, nurses showed notably higher level of chromosome damage. On the other hand, no significant difference in micronuclei frequency was observed between nurses and pharmacists. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The results of this study confirmed that handling antineoplastic drugs without appropriate precautions imposed a genotoxic risk for exposed healthcare workers. These results address the need for regular biomonitoring of exposed personnel. In addition, they call attention to the need for proper implementation of intervention measures aiming to eliminate or significantly reduce worker exposure and prevent untoward biological effects. Copyright [copy 2011 John Wiley & Sons, Ltd. Pharmacists and nurses handling antineoplastic drugs showed significantly increased chromosomal aberration and micronuclei frequencies. Compared with pharmacists, nurses showed notably higher levels of chromosome damage, but not micronuclei frequency. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of safety standards have contributed to the exposure risk for personnel who handle these substances. Interactions of antineoplastic drugs with biological structures vary according to the drug(s) and the individual's genetic susceptibility. This study was carried out to evaluate the genome damage induced by exposure to antineoplastic drugs in nurses (n = 20) and pharmacists (n = 18) working in the Oncology Department of Tanta Cancer Center. Thirty subjects matched in age, gender and smoking habit were selected as controls. Both chromosomal aberration analysis and micronucleus assay were used to evaluate genome damage in peripheral blood lymphocytes of the study subjects. The numbers of aberrant lymphocytes, as well as chromosomal aberration and micronuclei frequencies, were significantly increased in exposed personnel in comparison to matched controls. Compared with pharmacists, nurses showed notably higher level of chromosome damage. On the other hand, no significant difference in micronuclei frequency was observed between nurses and pharmacists. Correlation analyses pointed to the influence of age and duration of occupational exposure on the level of chromosome damage among exposed subjects. The results of this study confirmed that handling antineoplastic drugs without appropriate precautions imposed a genotoxic risk for exposed healthcare workers. These results address the need for regular biomonitoring of exposed personnel. In addition, they call attention to the need for proper implementation of intervention measures aiming to eliminate or significantly reduce worker exposure and prevent untoward biological effects. |
| Author | El-Ebiary, Ahmad A. Abuelfadl, Arwa A. Sarhan, Naglaa I. |
| Author_xml | – sequence: 1 givenname: Ahmad A. surname: El-Ebiary fullname: El-Ebiary, Ahmad A. email: a.ebiary@gmail.com organization: Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt – sequence: 2 givenname: Arwa A. surname: Abuelfadl fullname: Abuelfadl, Arwa A. organization: Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Tanta University, Tanta, Egypt – sequence: 3 givenname: Naglaa I. surname: Sarhan fullname: Sarhan, Naglaa I. organization: Department of Histology, Faculty of Medicine, Tanta University, Tanta, Egypt |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21935972$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkltv1DAQhS1URLcLEr8AWeKFlyy-xHHyWPWyBVYgUBG8WbbjbL1k7WA7sPn39dJSRAWCJ0vjb85o5pwjcOC8MwA8xWiBESIvNzItMKfsAZhh1DQFJhU9ADNEKlSUlH8-BEcxbhDKf6R-BA4JbihrOJmB3dk32Y8yWe-g7-DaOJ_8zmqbJmhdO2rTQjVBsxt8HIOByUPpknXGD72MyWrYhnEdMwv7aTtceT0lE_dS3mnf-_UE3RhiLknXwuFKhq3UNqb4GDzsZB_Nk9t3Dj6en12eXBSrd8tXJ8erQpeMskJTJVnFDdW6MooxRYguO9W1XdVIRDnq2jbXlCwbzKsGE1IarghmsuqY4orOwYsb3SH4r6OJSWxt1KbvZd5hjALzPIbyipT_RkvaEEI4-g-U1ASVFc53noPn99CNH4PLO-8Fy7quG4Iy9eyWGtXWtGIIdivDJH469WuiDj7GYLo7BCOxD4HIIRD7EGR0cQ_Ndv6wOAVp-z81FDcN321vpr8Ki9fHl7_z2Uizu-Nl-CIqTjkTn94uxftVjT6cLs_FG3oNwhLSUA |
| CitedBy_id | crossref_primary_10_1080_09553002_2023_2241901 crossref_primary_10_1136_oemed_2022_108623 crossref_primary_10_1188_16_CJON_617_622 crossref_primary_10_3390_ijerph21121689 crossref_primary_10_1016_j_toxac_2017_10_001 crossref_primary_10_1177_10781552211038518 crossref_primary_10_1016_j_mrrev_2016_05_001 crossref_primary_10_1177_21650799251348477 crossref_primary_10_1177_11297298211044017 crossref_primary_10_1007_s00420_014_0993_y crossref_primary_10_1007_s00420_023_01969_6 crossref_primary_10_3390_ijerph18168445 crossref_primary_10_1177_1078155216676632 crossref_primary_10_1093_annweh_wxac075 crossref_primary_10_1016_j_enfcle_2019_07_004 crossref_primary_10_1177_10781552241276530 crossref_primary_10_1016_j_clinthera_2014_01_016 crossref_primary_10_1177_10781552211003638 crossref_primary_10_1007_s00204_023_03481_9 crossref_primary_10_3390_ijerph9082636 crossref_primary_10_1134_S1022795422050052 crossref_primary_10_1016_j_enfcli_2019_07_003 crossref_primary_10_1080_15459624_2014_949725 crossref_primary_10_1007_s43188_019_00003_7 crossref_primary_10_1016_j_mrrev_2017_08_002 crossref_primary_10_1080_15287394_2014_910158 crossref_primary_10_1177_1078155216643860 crossref_primary_10_1093_annweh_wxaa100 crossref_primary_10_1177_10781552211053253 crossref_primary_10_1016_j_mrgentox_2023_503681 crossref_primary_10_33808_clinexphealthsci_563988 crossref_primary_10_1097_NAN_0000000000000361 crossref_primary_10_1111_ijpp_12590 crossref_primary_10_1016_j_ijnurstu_2024_104889 |
| Cites_doi | 10.1016/j.mrgentox.2005.07.008 10.1093/mutage/gei048 10.1016/j.ijheh.2008.10.001 10.1016/S0165-1218(97)00054-2 10.1136/oem.55.3.145 10.1093/ajhp/53.22.2713 10.1080/152873901300018011 10.1016/0165-1218(87)90021-8 10.1002/ajim.20189 10.1016/S1383-5718(98)00084-9 10.1539/joh.48.517 10.1016/S1383-5718(01)00236-4 10.1007/s004200000164 10.1016/S1383-5718(00)00107-8 10.1016/0165-1218(90)90045-4 10.1097/00002820-199308000-00005 10.1016/j.mrgentox.2006.10.014 10.1016/0165-1161(85)90015-9 10.1191/0960327102ht230oa 10.1002/(SICI)1097-0274(199607)30:1<67::AID-AJIM11>3.0.CO;2-6 10.1093/jnci/92.11.874 10.1093/mutage/gem032 10.1007/s004200050208 10.1093/carcin/bgl177 10.1093/mutage/gen060 10.1016/0165-1218(95)90086-1 |
| ContentType | Journal Article |
| Copyright | Copyright © 2011 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd. |
| Copyright_xml | – notice: Copyright © 2011 John Wiley & Sons, Ltd. – notice: Copyright © 2013 John Wiley & Sons, Ltd. |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7ST 7TK 7U7 C1K K9. SOI 7X8 7T2 7T5 H94 8FD FR3 KR7 |
| DOI | 10.1002/jat.1735 |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Environment Abstracts Neurosciences Abstracts Toxicology Abstracts Environmental Sciences and Pollution Management ProQuest Health & Medical Complete (Alumni) Environment Abstracts MEDLINE - Academic Health and Safety Science Abstracts (Full archive) Immunology Abstracts AIDS and Cancer Research Abstracts Technology Research Database Engineering Research Database Civil Engineering Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Toxicology Abstracts Neurosciences Abstracts Environment Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic AIDS and Cancer Research Abstracts Health & Safety Science Abstracts Immunology Abstracts Technology Research Database Civil Engineering Abstracts Engineering Research Database |
| DatabaseTitleList | ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic CrossRef Technology Research Database AIDS and Cancer Research Abstracts MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1099-1263 |
| EndPage | 201 |
| ExternalDocumentID | 3079189021 21935972 10_1002_jat_1735 JAT1735 ark_67375_WNG_QL80RDGF_K |
| Genre | article Journal Article |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHQN AAMMB AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABEFU ABEML ABIJN ABJNI ABPVW ACAHQ ACBWZ ACCZN ACGFO ACGFS ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEGXH AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFNX AFFPM AFGKR AFRAH AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHMBA AI. AIAGR AIDQK AIDYY AIQQE AITYG AIURR AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BSCLL BY8 CS3 D-E D-F DCZOG DPXWK DR2 DRFUL DRSTM EBD EBS EDH EJD F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA GWYGA H.T H.X HF~ HGLYW HHZ HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6Q MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG P2P P2W P2X P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RX1 RYL SAMSI SUPJJ UB1 V8K VH1 W8V W99 WBFHL WBKPD WH7 WIB WIH WIK WJL WOHZO WQJ WXSBR WYISQ XG1 XPP XV2 YHZ ZXP ZZTAW ~02 ~IA ~KM ~WT AAHHS ACCFJ ADZOD AEEZP AEQDE AEUQT AFPWT AIWBW AJBDE RWI WRC WUP WWP YCJ AAYXX BANNL CITATION O8X CGR CUY CVF ECM EIF NPM 7ST 7TK 7U7 C1K K9. SOI 7X8 7T2 7T5 H94 8FD FR3 KR7 |
| ID | FETCH-LOGICAL-c4535-c3ba567e3cc6eb55b22c4fbfdf69a0370fddb22ba4917691224e7b215a6f5b7b3 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 43 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000314070200005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0260-437X 1099-1263 |
| IngestDate | Thu Sep 04 17:23:17 EDT 2025 Tue Oct 07 09:52:06 EDT 2025 Thu Oct 02 11:25:12 EDT 2025 Sat Nov 29 14:39:44 EST 2025 Thu Apr 03 07:09:35 EDT 2025 Tue Nov 18 21:20:37 EST 2025 Sat Nov 29 07:06:37 EST 2025 Wed Jan 22 16:21:32 EST 2025 Sun Sep 21 06:16:17 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor Copyright © 2011 John Wiley & Sons, Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4535-c3ba567e3cc6eb55b22c4fbfdf69a0370fddb22ba4917691224e7b215a6f5b7b3 |
| Notes | istex:1FDB13C24A02EC3E6D28237357250BACDE6DCFD7 ark:/67375/WNG-QL80RDGF-K ArticleID:JAT1735 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 21935972 |
| PQID | 1434888920 |
| PQPubID | 105373 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_1753537624 proquest_miscellaneous_1439222704 proquest_miscellaneous_1282046119 proquest_journals_1434888920 pubmed_primary_21935972 crossref_primary_10_1002_jat_1735 crossref_citationtrail_10_1002_jat_1735 wiley_primary_10_1002_jat_1735_JAT1735 istex_primary_ark_67375_WNG_QL80RDGF_K |
| PublicationCentury | 2000 |
| PublicationDate | 2013-03 March 2013 2013-03-00 2013-Mar 20130301 |
| PublicationDateYYYYMMDD | 2013-03-01 |
| PublicationDate_xml | – month: 03 year: 2013 text: 2013-03 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: Bognor Regis |
| PublicationSubtitle | JAT |
| PublicationTitle | Journal of applied toxicology |
| PublicationTitleAlternate | J. Appl. Toxicol |
| PublicationYear | 2013 |
| Publisher | Blackwell Publishing Ltd Wiley Subscription Services, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Wiley Subscription Services, Inc |
| References | Deng H, Zhang M, He J, Wu W, Jin L, Zheng W, Lou J, Wang B. 2005. Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points. Mutagenesis 20: 351-357. Kopjar N, Garaj-Vrhovac V, Kasuba V, Rozgaj R, Ramic S, Pavlica V, Zeljezic D. 2009. Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: a multi-bio marker approach. Int. J. Hyg. Environ. Health 212: 414-431. Baker ES, Connor TH. 1996. Monitoring occupational exposure to cancer chemotherapy drugs. Am. J. Health Syst. Pharm. 53: 2713-2723. Fucic A, Jazbec A, Mijic A, Seso-Simic D, Tomek R. 1998. Cytogenetic consequences after occupational exposure to antineoplastic drugs. Mutat. Res. 416: 59-66. Buckton KE, Evans HJ. 1973. Methods for the Analysis of Human Chromosome Aberrations. World Health Organization: Geneva. Burgaz S, Karahalil B, Canli Z, Terzioglu F, Ancel G, Anzion RBM, Bos RP, Huttner E. 2002. Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations. Hum. Exp. Toxicol. 21: 129-135. Valanis B, Vollmer WM, Labuhn KT, Glass AG. 1993. Acute symptoms associated with antineoplastic drug handling among nurses. Cancer Nurs. 16: 288-295. Hessel H, Radon K, Pethran A, Maisch B, Grombmair S, Sautter I, Fruhmann G. 2001. The genotoxic risk of hospital, pharmacy and medical personnel occupationally exposed to cytostatic drugs - evaluation by the micronucleus assay. Mutat. Res. 497: 101-109. Surralles J, Natarajan AT. 1997. Human lymphocytes micronucleus assay in Europe. An international survey. Mutat. Res. 392: 165-174. Fuchs J, Hengstler JG, Jung D, Hiltl G, Konietzko J, Oesch F. 1995. DNA damage in nurses handling antineoplastic agents. Mutat. Res. 342: 17-23. Maluf SW, Erdtmann B. 2000. Follow up study of the genetic damage in lymphocytes of pharmacists and nurses handling antineoplastic drugs evaluated by cytokinesis-block micronuclei analysis and single cell gel electrophoresis assay. Mutat. Res. 471: 21-27. Hagmar L, Bonassi S, Stromberg U, Brogger A, Knudsen LE, Norppa H, Reuterwall C. 1998. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 58: 4117-4121. Cavallo D, Ursini CL, Perniconi B, Francesco AD, Giglio M, Rubino FM, Marinaccio A, Iavicoli S. 2005. Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees. Mutat. Res. 587: 45-51. Cavallo D, Ursini CL, Omodeo-Sale E, Iavicoli S. 2007. Micronucleus induction and FISH analysis in buccal cells and lymphocytes of nurses administering antineoplastic drugs. Mutat. Res. 628: 11-18. Rekhadevi PV, Sailaja N, Chandrasekhar M, Mahboob M, Rahman MF, Grover P. 2007. Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs. Mutagenesis 22: 395-401. Bonassi S, Znaor A, Ceppi M, Lando C, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Ban S, Barale R, Bigatti MP, Bolognesi C, Cebulska-Wasilewska A, Fabianova E, Fucic A, Hagmar L, Joksic G, Martelli A, Migliore L, Mirkova E, Scarfi MR, Zijno A, Norppa H, Fenech M. 2007. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28: 625-631. Ensslin AS, Huber R, Pethran A, Rommelt H, Schierl R, Kulka U, Fruhmann G. 1997. Biological monitoring of hospital pharmacy personnel occupationally exposed to cytostatic drugs: urinary excretion and cytogenetics study. Int. Arch. Occup. Environ. Health 70: 205-208. Yoshida J, Kosaka H, Tomioka K, Kumagai S. 2006. Genotoxic risks to nurses from contamination of the work environment with antineoplastic drugs in Japan. J. Occup. Health 48: 517-522. Kevekordes S, Gebel TW, Hellwig M, Dames W, Dunkelberg H. 1998. Human effect monitoring in cases of occupational exposure to antineoplastic drugs: a method comparison. Occup. Environ. Med. 55: 145-149. Preston RJ, Dean BS, Galloway S, Holden H, McFee AF, Shelby M. 1987. Mammalian in vivo cytogenetic assays: analysis of chromosome aberrations in bone marrow cells. Mutat. Res. 189: 157-165. Laffon B, Teixeira JP, Silva S, Loureiro J, Torres J, Pa´saro E, Me´ndez J, Mayan O. 2005. Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes. Am. J. Ind. Med. 48: 128-136. Fenech M, Morely AA. 1985. Measurement of micronuclei in lymphocytes. Mutat. Res. 147: 29-36. Jakab MG, Major J, Tompa A. 2001. Follow-up genotoxicological monitoring of nurses handling antineoplastic drugs. J. Toxicol. Environ. Health 62: 307-318. Berwick M, Vineis P. 2000. Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J. Natl. Cancer Inst. 92: 874-897. Brumen V, Horvat D. 1996. Work environment influence on cytostatics induced genotoxicity in oncologic nurses. Am. J. Ind. Med. 30: 67-71. Oestreicher U, Stephan G, Glatzel M. 1990. Chromosome and SCE analysis in peripheral lymphocytes of persons occupationally exposed to cytostatic drugs handled with and without use of safety covers. Mutat. Res. 242: 271-277. Rombaldi F, Cassini C, Salvador M, Saffi J, Erdtmann B. 2009. Occupational risk assessment of genotoxicity and oxidative stress in workers handling anti-neoplastic drugs during a working week. Mutagenesis 24: 143-148. Turci R, Sottani C, Spagnoli G, Minoia C. 2003. Biological and environmental monitoring of hospital personnel exposed to antineoplastic agents: a review of analytical methods. J. Chromatogr. 789: 169-209. Pilger A, Kohler I, Stettner H, Mader RM, Rizovski B, Terkola R, Diem E, Franz-Hainzl E, Konnaris C, Valic E, Rudiger HW. 2000. Long-term monitoring of sister chromatid exchanges and micronucleus frequencies in pharmacy personnel occupationally exposed to cytostatic drugs. Int. Arch. Occup. Environ. Health 73: 442-448. 2009; 24 1987; 189 2011 1997; 392 1998; 416 2000; 73 2000; 92 1996; 30 2005; 20 1985; 147 1973 2009; 212 2000; 471 2007; 628 2005; 48 1990; 242 2001; 62 1996; 53 2007; 28 2001; 497 2003; 789 1997; 70 1993; 16 2005; 587 2002; 21 2006; 48 1986 1995; 342 2007; 22 1998; 55 1998; 58 e_1_2_6_32_1 e_1_2_6_10_1 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_17_1 Turci R (e_1_2_6_29_1) 2003; 789 e_1_2_6_18_1 Buckton KE (e_1_2_6_6_1) 1973 e_1_2_6_16_1 Hagmar L (e_1_2_6_15_1) 1998; 58 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 Watt JL (e_1_2_6_31_1) 1986 e_1_2_6_7_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_28_1 e_1_2_6_27_1 e_1_2_6_26_1 |
| References_xml | – reference: Maluf SW, Erdtmann B. 2000. Follow up study of the genetic damage in lymphocytes of pharmacists and nurses handling antineoplastic drugs evaluated by cytokinesis-block micronuclei analysis and single cell gel electrophoresis assay. Mutat. Res. 471: 21-27. – reference: Baker ES, Connor TH. 1996. Monitoring occupational exposure to cancer chemotherapy drugs. Am. J. Health Syst. Pharm. 53: 2713-2723. – reference: Kevekordes S, Gebel TW, Hellwig M, Dames W, Dunkelberg H. 1998. Human effect monitoring in cases of occupational exposure to antineoplastic drugs: a method comparison. Occup. Environ. Med. 55: 145-149. – reference: Bonassi S, Znaor A, Ceppi M, Lando C, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Ban S, Barale R, Bigatti MP, Bolognesi C, Cebulska-Wasilewska A, Fabianova E, Fucic A, Hagmar L, Joksic G, Martelli A, Migliore L, Mirkova E, Scarfi MR, Zijno A, Norppa H, Fenech M. 2007. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28: 625-631. – reference: Buckton KE, Evans HJ. 1973. Methods for the Analysis of Human Chromosome Aberrations. World Health Organization: Geneva. – reference: Burgaz S, Karahalil B, Canli Z, Terzioglu F, Ancel G, Anzion RBM, Bos RP, Huttner E. 2002. Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations. Hum. Exp. Toxicol. 21: 129-135. – reference: Surralles J, Natarajan AT. 1997. Human lymphocytes micronucleus assay in Europe. An international survey. Mutat. Res. 392: 165-174. – reference: Cavallo D, Ursini CL, Perniconi B, Francesco AD, Giglio M, Rubino FM, Marinaccio A, Iavicoli S. 2005. Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees. Mutat. Res. 587: 45-51. – reference: Valanis B, Vollmer WM, Labuhn KT, Glass AG. 1993. Acute symptoms associated with antineoplastic drug handling among nurses. Cancer Nurs. 16: 288-295. – reference: Deng H, Zhang M, He J, Wu W, Jin L, Zheng W, Lou J, Wang B. 2005. Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points. Mutagenesis 20: 351-357. – reference: Fenech M, Morely AA. 1985. Measurement of micronuclei in lymphocytes. Mutat. Res. 147: 29-36. – reference: Oestreicher U, Stephan G, Glatzel M. 1990. Chromosome and SCE analysis in peripheral lymphocytes of persons occupationally exposed to cytostatic drugs handled with and without use of safety covers. Mutat. Res. 242: 271-277. – reference: Cavallo D, Ursini CL, Omodeo-Sale E, Iavicoli S. 2007. Micronucleus induction and FISH analysis in buccal cells and lymphocytes of nurses administering antineoplastic drugs. Mutat. Res. 628: 11-18. – reference: Kopjar N, Garaj-Vrhovac V, Kasuba V, Rozgaj R, Ramic S, Pavlica V, Zeljezic D. 2009. Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: a multi-bio marker approach. Int. J. Hyg. Environ. Health 212: 414-431. – reference: Laffon B, Teixeira JP, Silva S, Loureiro J, Torres J, Pa´saro E, Me´ndez J, Mayan O. 2005. Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes. Am. J. Ind. Med. 48: 128-136. – reference: Hessel H, Radon K, Pethran A, Maisch B, Grombmair S, Sautter I, Fruhmann G. 2001. The genotoxic risk of hospital, pharmacy and medical personnel occupationally exposed to cytostatic drugs - evaluation by the micronucleus assay. Mutat. Res. 497: 101-109. – reference: Turci R, Sottani C, Spagnoli G, Minoia C. 2003. Biological and environmental monitoring of hospital personnel exposed to antineoplastic agents: a review of analytical methods. J. Chromatogr. 789: 169-209. – reference: Rekhadevi PV, Sailaja N, Chandrasekhar M, Mahboob M, Rahman MF, Grover P. 2007. Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs. Mutagenesis 22: 395-401. – reference: Yoshida J, Kosaka H, Tomioka K, Kumagai S. 2006. Genotoxic risks to nurses from contamination of the work environment with antineoplastic drugs in Japan. J. Occup. Health 48: 517-522. – reference: Rombaldi F, Cassini C, Salvador M, Saffi J, Erdtmann B. 2009. Occupational risk assessment of genotoxicity and oxidative stress in workers handling anti-neoplastic drugs during a working week. Mutagenesis 24: 143-148. – reference: Ensslin AS, Huber R, Pethran A, Rommelt H, Schierl R, Kulka U, Fruhmann G. 1997. Biological monitoring of hospital pharmacy personnel occupationally exposed to cytostatic drugs: urinary excretion and cytogenetics study. Int. Arch. Occup. Environ. Health 70: 205-208. – reference: Brumen V, Horvat D. 1996. Work environment influence on cytostatics induced genotoxicity in oncologic nurses. Am. J. Ind. Med. 30: 67-71. – reference: Fuchs J, Hengstler JG, Jung D, Hiltl G, Konietzko J, Oesch F. 1995. DNA damage in nurses handling antineoplastic agents. Mutat. Res. 342: 17-23. – reference: Pilger A, Kohler I, Stettner H, Mader RM, Rizovski B, Terkola R, Diem E, Franz-Hainzl E, Konnaris C, Valic E, Rudiger HW. 2000. Long-term monitoring of sister chromatid exchanges and micronucleus frequencies in pharmacy personnel occupationally exposed to cytostatic drugs. Int. Arch. Occup. Environ. Health 73: 442-448. – reference: Hagmar L, Bonassi S, Stromberg U, Brogger A, Knudsen LE, Norppa H, Reuterwall C. 1998. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 58: 4117-4121. – reference: Preston RJ, Dean BS, Galloway S, Holden H, McFee AF, Shelby M. 1987. Mammalian in vivo cytogenetic assays: analysis of chromosome aberrations in bone marrow cells. Mutat. Res. 189: 157-165. – reference: Fucic A, Jazbec A, Mijic A, Seso-Simic D, Tomek R. 1998. Cytogenetic consequences after occupational exposure to antineoplastic drugs. Mutat. Res. 416: 59-66. – reference: Berwick M, Vineis P. 2000. Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J. Natl. Cancer Inst. 92: 874-897. – reference: Jakab MG, Major J, Tompa A. 2001. Follow-up genotoxicological monitoring of nurses handling antineoplastic drugs. J. Toxicol. Environ. Health 62: 307-318. – volume: 58 start-page: 4117 year: 1998 end-page: 4121 article-title: Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH) publication-title: Cancer Res. – year: 2011 – volume: 16 start-page: 288 year: 1993 end-page: 295 article-title: Acute symptoms associated with antineoplastic drug handling among nurses publication-title: Cancer Nurs. – volume: 48 start-page: 517 year: 2006 end-page: 522 article-title: Genotoxic risks to nurses from contamination of the work environment with antineoplastic drugs in Japan publication-title: J. Occup. Health – volume: 92 start-page: 874 year: 2000 end-page: 897 article-title: Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review publication-title: J. Natl. Cancer Inst. – volume: 392 start-page: 165 year: 1997 end-page: 174 article-title: Human lymphocytes micronucleus assay in Europe. An international survey publication-title: Mutat. Res. – volume: 147 start-page: 29 year: 1985 end-page: 36 article-title: Measurement of micronuclei in lymphocytes publication-title: Mutat. Res. – volume: 587 start-page: 45 year: 2005 end-page: 51 article-title: Evaluation of genotoxic effects induced by exposure to antineoplastic drugs in lymphocytes and exfoliated buccal cells of oncology nurses and pharmacy employees publication-title: Mutat. Res. – volume: 471 start-page: 21 year: 2000 end-page: 27 article-title: Follow up study of the genetic damage in lymphocytes of pharmacists and nurses handling antineoplastic drugs evaluated by cytokinesis‐block micronuclei analysis and single cell gel electrophoresis assay publication-title: Mutat. Res. – year: 1973 – volume: 28 start-page: 625 year: 2007 end-page: 631 article-title: An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans publication-title: Carcinogenesis – volume: 24 start-page: 143 year: 2009 end-page: 148 article-title: Occupational risk assessment of genotoxicity and oxidative stress in workers handling anti‐neoplastic drugs during a working week publication-title: Mutagenesis – volume: 416 start-page: 59 year: 1998 end-page: 66 article-title: Cytogenetic consequences after occupational exposure to antineoplastic drugs publication-title: Mutat. Res. – volume: 497 start-page: 101 year: 2001 end-page: 109 article-title: The genotoxic risk of hospital, pharmacy and medical personnel occupationally exposed to cytostatic drugs – evaluation by the micronucleus assay publication-title: Mutat. Res. – volume: 242 start-page: 271 year: 1990 end-page: 277 article-title: Chromosome and SCE analysis in peripheral lymphocytes of persons occupationally exposed to cytostatic drugs handled with and without use of safety covers publication-title: Mutat. Res. – volume: 789 start-page: 169 year: 2003 end-page: 209 article-title: Biological and environmental monitoring of hospital personnel exposed to antineoplastic agents: a review of analytical methods publication-title: J. Chromatogr. – volume: 21 start-page: 129 year: 2002 end-page: 135 article-title: Assessment of genotoxic damage in nurses occupationally exposed to antineoplastics by the analysis of chromosomal aberrations publication-title: Hum. Exp. Toxicol. – volume: 342 start-page: 17 year: 1995 end-page: 23 article-title: DNA damage in nurses handling antineoplastic agents publication-title: Mutat. Res. – volume: 48 start-page: 128 year: 2005 end-page: 136 article-title: Genotoxic effects in a population of nurses handling antineoplastic drugs, and relationship with genetic polymorphisms in DNA repair enzymes publication-title: Am. J. Ind. Med. – volume: 628 start-page: 11 year: 2007 end-page: 18 article-title: Micronucleus induction and FISH analysis in buccal cells and lymphocytes of nurses administering antineoplastic drugs publication-title: Mutat. Res. – volume: 22 start-page: 395 year: 2007 end-page: 401 article-title: Genotoxicity assessment in oncology nurses handling anti‐neoplastic drugs publication-title: Mutagenesis – volume: 70 start-page: 205 year: 1997 end-page: 208 article-title: Biological monitoring of hospital pharmacy personnel occupationally exposed to cytostatic drugs: urinary excretion and cytogenetics study publication-title: Int. Arch. Occup. Environ. Health – volume: 62 start-page: 307 year: 2001 end-page: 318 article-title: Follow‐up genotoxicological monitoring of nurses handling antineoplastic drugs publication-title: J. Toxicol. Environ. Health – volume: 53 start-page: 2713 year: 1996 end-page: 2723 article-title: Monitoring occupational exposure to cancer chemotherapy drugs publication-title: Am. J. Health Syst. Pharm. – volume: 73 start-page: 442 year: 2000 end-page: 448 article-title: Long‐term monitoring of sister chromatid exchanges and micronucleus frequencies in pharmacy personnel occupationally exposed to cytostatic drugs publication-title: Int. Arch. Occup. Environ. Health – volume: 55 start-page: 145 year: 1998 end-page: 149 article-title: Human effect monitoring in cases of occupational exposure to antineoplastic drugs: a method comparison publication-title: Occup. Environ. Med. – start-page: 39 year: 1986 end-page: 49 – volume: 212 start-page: 414 year: 2009 end-page: 431 article-title: Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: a multi‐bio marker approach publication-title: Int. J. Hyg. Environ. Health – volume: 30 start-page: 67 year: 1996 end-page: 71 article-title: Work environment influence on cytostatics induced genotoxicity in oncologic nurses publication-title: Am. J. Ind. Med. – volume: 20 start-page: 351 year: 2005 end-page: 357 article-title: Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end‐points publication-title: Mutagenesis – volume: 189 start-page: 157 year: 1987 end-page: 165 article-title: Mammalian in vivo cytogenetic assays: analysis of chromosome aberrations in bone marrow cells publication-title: Mutat. Res. – ident: e_1_2_6_8_1 doi: 10.1016/j.mrgentox.2005.07.008 – ident: e_1_2_6_10_1 doi: 10.1093/mutage/gei048 – ident: e_1_2_6_20_1 doi: 10.1016/j.ijheh.2008.10.001 – ident: e_1_2_6_28_1 doi: 10.1016/S0165-1218(97)00054-2 – ident: e_1_2_6_19_1 doi: 10.1136/oem.55.3.145 – ident: e_1_2_6_2_1 doi: 10.1093/ajhp/53.22.2713 – ident: e_1_2_6_18_1 doi: 10.1080/152873901300018011 – ident: e_1_2_6_25_1 doi: 10.1016/0165-1218(87)90021-8 – ident: e_1_2_6_21_1 doi: 10.1002/ajim.20189 – ident: e_1_2_6_14_1 doi: 10.1016/S1383-5718(98)00084-9 – ident: e_1_2_6_32_1 doi: 10.1539/joh.48.517 – volume: 58 start-page: 4117 year: 1998 ident: e_1_2_6_15_1 article-title: Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH) publication-title: Cancer Res. – ident: e_1_2_6_16_1 doi: 10.1016/S1383-5718(01)00236-4 – ident: e_1_2_6_24_1 doi: 10.1007/s004200000164 – ident: e_1_2_6_22_1 doi: 10.1016/S1383-5718(00)00107-8 – ident: e_1_2_6_23_1 doi: 10.1016/0165-1218(90)90045-4 – ident: e_1_2_6_30_1 doi: 10.1097/00002820-199308000-00005 – ident: e_1_2_6_17_1 – ident: e_1_2_6_9_1 doi: 10.1016/j.mrgentox.2006.10.014 – ident: e_1_2_6_12_1 doi: 10.1016/0165-1161(85)90015-9 – ident: e_1_2_6_7_1 doi: 10.1191/0960327102ht230oa – ident: e_1_2_6_5_1 doi: 10.1002/(SICI)1097-0274(199607)30:1<67::AID-AJIM11>3.0.CO;2-6 – ident: e_1_2_6_3_1 doi: 10.1093/jnci/92.11.874 – ident: e_1_2_6_26_1 doi: 10.1093/mutage/gem032 – ident: e_1_2_6_11_1 doi: 10.1007/s004200050208 – volume: 789 start-page: 169 year: 2003 ident: e_1_2_6_29_1 article-title: Biological and environmental monitoring of hospital personnel exposed to antineoplastic agents: a review of analytical methods publication-title: J. Chromatogr. – ident: e_1_2_6_4_1 doi: 10.1093/carcin/bgl177 – volume-title: Methods for the Analysis of Human Chromosome Aberrations year: 1973 ident: e_1_2_6_6_1 – start-page: 39 volume-title: Human Cytogenetics: a Practical Approach year: 1986 ident: e_1_2_6_31_1 – ident: e_1_2_6_27_1 doi: 10.1093/mutage/gen060 – ident: e_1_2_6_13_1 doi: 10.1016/0165-1218(95)90086-1 |
| SSID | ssj0009928 |
| Score | 2.2139206 |
| Snippet | ABSTRACT
The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with... The hazards of handling antineoplastic drugs have been raised and discussed in several studies. Introduction of new antineoplastics together with abuse of... |
| SourceID | proquest pubmed crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 196 |
| SubjectTerms | Aberration Abnormal Karyotype Adult Antineoplastic Agents - adverse effects antineoplastic drug chromosomal aberration Chromosomes Damage DNA Damage Drugs Exposure Female genotoxicity Health Facility Environment Humans Karyotyping lymphocyte Lymphocytes Lymphocytes - drug effects Lymphocytes - pathology Male Materials handling Micronuclei, Chromosome-Defective - chemically induced micronucleus assay Micronucleus Tests Mutagens - adverse effects nurse Nurses Nursing Staff, Hospital Occupational Exposure - adverse effects Occupational hazards pharmacist Pharmacists Prescription drugs Toxicity |
| Title | Evaluation of genotoxicity induced by exposure to antineoplastic drugs in lymphocytes of oncology nurses and pharmacists |
| URI | https://api.istex.fr/ark:/67375/WNG-QL80RDGF-K/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjat.1735 https://www.ncbi.nlm.nih.gov/pubmed/21935972 https://www.proquest.com/docview/1434888920 https://www.proquest.com/docview/1282046119 https://www.proquest.com/docview/1439222704 https://www.proquest.com/docview/1753537624 |
| Volume | 33 |
| WOSCitedRecordID | wos000314070200005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1099-1263 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0009928 issn: 0260-437X databaseCode: DRFUL dateStart: 19960101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fa9swED7WZA-Dsh_dj2btigYje6mpI9mW_VjWpoOVkJWW5c1IllW6lTjEyYj_-91ZjkOhLYU9JSSfY_ly8n0nn74D-KIGAmm6lZ7JB4mH72JP-8p4RgrLrbUYdVyzCTkaxZNJMm6qKmkvjNOHaBfcaGbU92ua4EqXRxvR0N-KGuqKcAu6HN026ED35GJ4db6R3E3qzqokmuUFQk7W0rM-P1ofeycYdcmuq_uY5l3iWkee4av_GfNreNnwTXbsHOQNPMunO9AfO8Hq6pBdbvZflYesz8YbKetqB7bdqh5zm5Xewuq0FQdnhWUk8LooVjcZUnmGyT26iWG6YvlqVtDKI1sUTFErCipTV6QIzcx8eV0ilt1W6EdFViHVpZ8qpu6czFWV4GGGzdxY0GDlO7ganl5---41vRu8LAhF6GVCqzCSuciyKNdhqDnPAqutsVGifCF9awx-plWA-WKU0PO9XGrkHyqyoZZavIfOtJjmu8DCXOmBb1RMaJ4gODbc-AaZF9KvIOjB1_WfmGaNsDn117hNnSQzT9HsKZm9B59b5MyJedyD6dd-0ALU_A8Vv8kw_TU6S3-ex_7Fydkw_dGD_bWjpM28LzGREnhHjBPu47nar3HG0mMYhdZeIgazXJK5HySPYJAn0i5lP3gEg5kmifFwxHxwjtoOGuOQwFSR49XU_vjg5aYYBej141OBe_CC1x1BqAxvHzqL-TL_BM-zv4ubcn4AW3ISHzQz8R-XMTgu |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwELZGiwQS4scYUBhgJFReFi214_wQT4itG1qpytSJvll2HKPB1FRNi5r_nrs4STVpTEg8tWq_NM71LvedY39HyHs14EDTbeSZbJB48C72tK-MZyJumbUWso5rNhGNx_Fslkx2yMdmL4zTh2gn3DAyqvs1BjhOSB9uVUN_Kuyoy8Ud0g3Ai0SHdI_OhxejreZuUrVWRdUsL-DRrNGe9dlhc-y1bNRFw25uoprXmWuVeoaP_mvQj8nDmnHST85FnpCdbL5L-hMnWV0e0Ol2B1ZxQPt0shWzLnfJAzevR912padkc9zKg9PcUpR4XeWbyxTIPIXyHhzFUF3SbLPIce6RrnKqsBkFLlRXqAlNzXL9owAsvSrBk_K0BLKLP5XP3TmpW1cChxm6cGMBixV75GJ4PP186tXdG7w0EFx4KddKhFHG0zTMtBCasTSw2hobJsrnkW-Ngc-0CqBiDBN8wpdFGhiICq3QkebPSGeez7MXhIpM6YFvVIxolgA4Nsz4BrgXELAg6JEPzb8o01raHDtsXEknyswkmF2i2XvkXYtcODmPGzD9yhFagFr-wuVvkZDfxyfy2yj2z49OhvKsR_YbT5F15BdQSnG4J8YJ8-Fc7dcQs_ggRoG114CBOheF7gfJLRhgirhP2Q9uwUCtiXI8DDDPnae2g4ZMxKFYZHA1lUP-9XIl5AF8ffmvwLfk3un060iOvozPXpH7rOoPgovy9klntVxnr8nd9Pfqsli-qQPyD9J5OzY |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwELbGihAS4scYUBhgJFReFi2181M8IboMtKoq0yb6ZtmxjQZTUzUtav577uIk1aQxIfHUqv3SONe73HeO_R0h7-WQA023safNMPXgXeIpX2pPx9wyay1kHddsIp5Mktksne6Qj-1eGKcP0U24YWTU92sMcLPQ9mirGvpTYkddHt4hvSBMI4jK3ugsuxhvNXfTurUqqmZ5AY9nrfasz47aY69lox4adnMT1bzOXOvUkz36r0E_Jg8bxkk_ORd5QnbMfI8Mpk6yujqk59sdWOUhHdDpVsy62iMP3LwedduVnpLNcScPTgtLUeJ1VWwucyDzFMp7cBRNVUXNZlHg3CNdFVRiMwpcqC5RE5rq5fpHCVh6VYEnFXkFZBd_qpi7c1K3rgQO03ThxgIWK_fJRXZ8_vmL13Rv8PIg5KGXcyXDKDY8zyOjwlAxlgdWWW2jVPo89q3W8JmSAVSMUYpP-EysgIHIyIYqVvwZ2Z0Xc_OC0NBINfS1TBDNUgAnmmlfA_cCAhYEffKh_RdF3kibY4eNK-FEmZkAsws0e5-865ALJ-dxA2ZQO0IHkMtfuPwtDsX3yYn4Nk78s9FJJk775KD1FNFEfgmlFId7YpIyH87VfQ0xiw9iJFh7DRioc1HofpjeggGmiPuU_eAWDNSaKMfDAPPceWo3aMhEHIpFBldTO-RfL1dAHsDXl_8KfEvuTUeZGH-dnL4i91ndHgTX5B2Q3dVybV6Tu_nv1WW5fNPE4x8INDqx |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+genotoxicity+induced+by+exposure+to+antineoplastic+drugs+in+lymphocytes+of+oncology+nurses+and+pharmacists&rft.jtitle=Journal+of+applied+toxicology&rft.au=El-Ebiary%2C+Ahmad+A.&rft.au=Abuelfadl%2C+Arwa+A.&rft.au=Sarhan%2C+Naglaa+I.&rft.date=2013-03-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0260-437X&rft.eissn=1099-1263&rft.volume=33&rft.issue=3&rft.spage=196&rft.epage=201&rft_id=info:doi/10.1002%2Fjat.1735&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_WNG_QL80RDGF_K |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0260-437X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0260-437X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0260-437X&client=summon |