Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice

Monoclonal antibodies or soluble receptors have been used to block over-produced endogenous cytokines. However, they have disadvantages of short half-lives, high costs, and possible adverse effects. Using interleukin (IL)-4 as a model target, we sought to develop a novel therapeutic strategy by cons...

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Bibliographic Details
Published in:	Allergy Vol. 62; no. 6; pp. 675 - 682
Main Authors:	Ma, Y, Hayglass, K.T, Becker, A.B, Halayko, A.J, Basu, S, Simons, F.E.R, Peng, Z
Format:	Journal Article
Language:	English
Published:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.06.2007 Blackwell Publishing Ltd
Subjects:	allergy Animals antagonists & inhibitors Asthma Asthma - physiopathology Asthma - prevention & control Autoantibodies Autoantibodies - immunology blood Blotting, Western Bronchial Hyperreactivity Bronchial Hyperreactivity - blood Bronchial Hyperreactivity - prevention & control Bronchoalveolar Lavage Fluid Bronchoalveolar Lavage Fluid - cytology Cytokines Cytokines - immunology cytology Enzyme-Linked Immunosorbent Assay Female Genetic Engineering Genetic Engineering - methods hepatitis B core antigen Hepatitis B Core Antigens Hepatitis B Core Antigens - immunology hypersensitivity Immunoglobulin G Immunoglobulin G - blood immunology immunotherapy Immunotherapy - methods interleukin-4 Interleukin-4 - antagonists & inhibitors Interleukin-4 - immunology methods Mice Mice, Inbred BALB C Peptides Peptides - immunology Peptides - therapeutic use physiopathology prevention & control therapeutic use vaccine Vaccines, Synthetic Vaccines, Synthetic - therapeutic use
ISSN:	0105-4538, 1398-9995, 0108-1675
Online Access:	Get full text
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