Novel strategy for applying hierarchical density-based spatial clustering of applications with noise towards spectroscopic analysis and detection of melanocytic lesions

Advancements in dermoscopy techniques have elucidated identifiable characteristics of melanoma which revolve around the asymmetrical constitution of melanocytic lesions consequent of unfettered proliferative growth as a malignant lesion. This study explores the applications of hierarchical density-b...

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Bibliographic Details
Published in:Melanoma research Vol. 31; no. 6; p. 526
Main Authors: Ye, Jason Yuan, Yu, Christopher, Husman, Tiffany, Chen, Bryan, Trikala, Aryaman
Format: Journal Article
Language:English
Published: England 01.12.2021
Subjects:
Cluster Analysis
Humans
Machine Learning - standards
Magnetic Resonance Spectroscopy - methods
Melanocytes - ultrastructure
Melanoma - diagnostic imaging
Skin Neoplasms - diagnostic imaging
ISSN:1473-5636, 1473-5636
Online Access:Get more information
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Summary:Advancements in dermoscopy techniques have elucidated identifiable characteristics of melanoma which revolve around the asymmetrical constitution of melanocytic lesions consequent of unfettered proliferative growth as a malignant lesion. This study explores the applications of hierarchical density-based spatial clustering of applications with noise (HDBSCAN) in terms of the direct diagnostic implications of applying agglomerative clustering in the spectroscopic analysis of malignant melanocytic lesions and benign dermatologic spots. 100 images of benign (n = 50) and malignant moles (n = 50) were sampled from the International Skin Imaging Collaboration Archive and processed through two separate Python algorithms. The first of which deconvolutes the three-digit tupled integer identifiers of pixel color in image composition into three separate matrices corresponding to the red, green and blue color channel. Statistical characterization of integer variance was utilized to determine the optimal channel for comparative analysis between malignant and benign image groups. The second applies HDBSCAN to the matrices, identifying agglomerative clustering in the dataset. The results indicate the potential diagnostic applications of HDBSCAN analysis in fast-processing dermoscopy, as optimization of clustering parameters according to a binary search strategy produced an accuracy of 85% in the classification of malignant and benign melanocytic lesions.
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ISSN:1473-5636
1473-5636
DOI:10.1097/CMR.0000000000000771