Management of Patients with Metastatic Castration-Sensitive Prostate Cancer in the Real-World Setting in the United States

This study provides a contemporary assessment of the treatment patterns, health care resource utilization (HRU) and costs among metastatic castration-sensitive prostate cancer (mCSPC) patients in the U.S. Adults with mCSPC were selected from Optum's de-identified Clinformatics® Data Mart Databa...

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Vydáno v:The Journal of urology Ročník 206; číslo 6; s. 1420
Hlavní autoři: Ryan, Charles J, Ke, Xuehua, Lafeuille, Marie-Hélène, Romdhani, Hela, Kinkead, Frederic, Lefebvre, Patrick, Petrilla, Allison, Pulungan, Zul, Kim, Seung, D'Andrea, Denise M, Francis, Peter, Freedland, Stephen J
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.12.2021
Témata:
Aged
Aged, 80 and over
Cohort Studies
Health Care Costs
Health Resources - statistics & numerical data
Humans
Male
Neoplasm Metastasis
Prostatic Neoplasms, Castration-Resistant - pathology
Prostatic Neoplasms, Castration-Resistant - therapy
Retrospective Studies
United States
United States
neoplasm metastasis, castration
health care costs
procedures and techniques utilization
prostatic neoplasms
ISSN:1527-3792, 1527-3792
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Shrnutí:This study provides a contemporary assessment of the treatment patterns, health care resource utilization (HRU) and costs among metastatic castration-sensitive prostate cancer (mCSPC) patients in the U.S. Adults with mCSPC were selected from Optum's de-identified Clinformatics® Data Mart Database (Commercial insurance/Medicare Advantage [COM/MA]; January 1, 2014-July 31, 2019) or Medicare Fee-for-Service (FFS; January 1, 2014-December 31, 2017). The index date was the first metastatic disease diagnosis date on/after the first prostate cancer diagnosis (without prior evidence of castration resistance). Patients were observed for 12 months pre-index (baseline) through their mCSPC period (from index until castration resistance or followup end). First-line (1L) mCSPC therapy was assessed during the mCSPC period; all-cause HRU and health plan-paid costs per-patient-per-year (PPPY) were measured during baseline and mCSPC periods. Among 6,517 COM/MA and 13,324 Medicare-FFS mCSPC patients over ∼10 months (median mCSPC period), 38% and 48% remained untreated/deferred treatment, and 45% and 46% received 1L androgen deprivation therapy (ADT) monotherapy, respectively. 1L abiraterone acetate and docetaxel were used among 7% and 6% of COM/MA and 1% and 2% of Medicare-FFS patients, respectively. HRU increased from baseline to mCSPC period, resulting in increased health plan-paid costs from $21,201 to $108,767 in COM/MA and from $16,819 to $69,639 PPPY in Medicare-FFS. This study highlights the limited use of newer therapies that improve survival in men with mCSPC in the U.S. HRU and costs increased substantially after onset of metastasis. Given the emergence of newer effective mCSPC therapies, further evaluation of future real-world mCSPC treatment patterns and outcomes is warranted.
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ISSN:1527-3792
1527-3792
DOI:10.1097/JU.0000000000002121