Association of dietary intake of milk and dairy products with blood concentrations of insulin-like growth factor 1 (IGF-1) in Bavarian adults

Purpose Circulating IGF-1 concentrations have been associated with higher cancer risk, particularly prostate, breast and colorectal cancer. There is evidence from observational and intervention studies that milk and dairy products intake is associated with higher IGF-1 concentrations, but results we...

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Vydáno v:European journal of nutrition Ročník 59; číslo 4; s. 1413 - 1420
Hlavní autoři: Romo Ventura, Eugenia, Konigorski, Stefan, Rohrmann, Sabine, Schneider, Harald, Stalla, Guenter K., Pischon, Tobias, Linseisen, Jakob, Nimptsch, Katharina
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2020
Springer Nature B.V
Témata:
Adolescent
Adult
adults
Aged
Aged, 80 and over
Animals
Biomarkers - blood
blood
blood sampling
Breast cancer
Cheese
cheeses
Chemistry
Chemistry and Materials Science
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
Cross-Sectional Studies
Dairy products
Dairy Products - statistics & numerical data
Diet - methods
diet recall
Dietary intake
Female
Food consumption
food frequency questionnaires
Germany
Humans
Insulin
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factors
Male
men
Middle Aged
Milk
Milk - statistics & numerical data
milk consumption
Nutrition
Original Contribution
Prostate cancer
Regression analysis
risk
surveys
women
Yogurt
Young Adult
Germany
Dairy
IGF-1
24-h dietary recall
Milk
ISSN:1436-6207, 1436-6215, 1436-6215
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Shrnutí:Purpose Circulating IGF-1 concentrations have been associated with higher cancer risk, particularly prostate, breast and colorectal cancer. There is evidence from observational and intervention studies that milk and dairy products intake is associated with higher IGF-1 concentrations, but results were not always consistent. The purpose of this study was to examine the relationship between dairy intake and circulating IGF-1 concentrations in participants of the Second Bavarian Food Consumption Survey, thereby providing data for a German population for the first time. Methods In this cross-sectional study of 526 men and women aged 18–80 years, in contrast to most previous investigations, dietary intake was assessed with a more detailed instrument than food frequency questionnaires (FFQs), i.e., by three 24-h dietary recalls conducted on random days close in time to the blood collection. Circulating IGF-1 concentrations were measured in blood samples. Multivariable linear regression models were used to examine the association of dairy intake with IGF-1 concentrations. Results Each 400 g increment in daily dairy intake was associated with 16.8 µg/L (95% CI 6.9, 26.7) higher IGF-1 concentrations. Each 200 g increment in milk per day was associated with 10.0 µg/L (95% CI 4.2, 15.8) higher IGF-1. In contrast, we observed no association between cheese or yogurt intake and IGF-1 concentrations. Conclusions Our findings are in line with most previous investigations and support the hypothesis that dairy and milk intake are associated with higher IGF-1 concentrations.
Bibliografie:ObjectType-Article-1
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ISSN:1436-6207
1436-6215
1436-6215
DOI:10.1007/s00394-019-01994-7