Patterns of the Predicted Mutation Burden in 19,778 Domesticated Barley Accessions Conserved Ex Situ
Long-term conservation of more than 7 million plant germplasm accessions in 1750 genebanks worldwide is a challenging mission. The extent of deleterious mutations present in conserved germplasm and the genetic risk associated with accumulative mutations are largely unknown. This study took advantage...
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| Vydané v: | International journal of molecular sciences Ročník 25; číslo 11; s. 5930 |
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Switzerland
MDPI AG
01.06.2024
MDPI |
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| Abstract | Long-term conservation of more than 7 million plant germplasm accessions in 1750 genebanks worldwide is a challenging mission. The extent of deleterious mutations present in conserved germplasm and the genetic risk associated with accumulative mutations are largely unknown. This study took advantage of published barley genomic data to predict sample-wise mutation burdens for 19,778 domesticated barley (Hordeum vulgare L.) accessions conserved ex situ. It was found that the conserved germplasm harbored 407 deleterious mutations and 337 (or 82%) identified deleterious alleles were present in 20 (or 0.1%) or fewer barley accessions. Analysis of the predicted mutation burdens revealed significant differences in mutation burden for several groups of barley germplasm (landrace > cultivar (or higher burden estimate in landrace than in cultivar); winter barley > spring barley; six-rowed barley > two-rowed barley; and 1000-accession core collection > non-core germplasm). Significant differences in burden estimate were also found among seven major geographical regions. The sample-wise predicted mutation burdens were positively correlated with the estimates of sample average pairwise genetic difference. These findings are significant for barley germplasm management and utilization and for a better understanding of the genetic risk in conserved plant germplasm. |
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| AbstractList | Long-term conservation of more than 7 million plant germplasm accessions in 1750 genebanks worldwide is a challenging mission. The extent of deleterious mutations present in conserved germplasm and the genetic risk associated with accumulative mutations are largely unknown. This study took advantage of published barley genomic data to predict sample-wise mutation burdens for 19,778 domesticated barley (Hordeum vulgare L.) accessions conserved ex situ. It was found that the conserved germplasm harbored 407 deleterious mutations and 337 (or 82%) identified deleterious alleles were present in 20 (or 0.1%) or fewer barley accessions. Analysis of the predicted mutation burdens revealed significant differences in mutation burden for several groups of barley germplasm (landrace > cultivar (or higher burden estimate in landrace than in cultivar); winter barley > spring barley; six-rowed barley > two-rowed barley; and 1000-accession core collection > non-core germplasm). Significant differences in burden estimate were also found among seven major geographical regions. The sample-wise predicted mutation burdens were positively correlated with the estimates of sample average pairwise genetic difference. These findings are significant for barley germplasm management and utilization and for a better understanding of the genetic risk in conserved plant germplasm. Long-term conservation of more than 7 million plant germplasm accessions in 1750 genebanks worldwide is a challenging mission. The extent of deleterious mutations present in conserved germplasm and the genetic risk associated with accumulative mutations are largely unknown. This study took advantage of published barley genomic data to predict sample-wise mutation burdens for 19,778 domesticated barley ( L.) accessions conserved ex situ. It was found that the conserved germplasm harbored 407 deleterious mutations and 337 (or 82%) identified deleterious alleles were present in 20 (or 0.1%) or fewer barley accessions. Analysis of the predicted mutation burdens revealed significant differences in mutation burden for several groups of barley germplasm (landrace > cultivar (or higher burden estimate in landrace than in cultivar); winter barley > spring barley; six-rowed barley > two-rowed barley; and 1000-accession core collection > non-core germplasm). Significant differences in burden estimate were also found among seven major geographical regions. The sample-wise predicted mutation burdens were positively correlated with the estimates of sample average pairwise genetic difference. These findings are significant for barley germplasm management and utilization and for a better understanding of the genetic risk in conserved plant germplasm. Long-term conservation of more than 7 million plant germplasm accessions in 1750 genebanks worldwide is a challenging mission. The extent of deleterious mutations present in conserved germplasm and the genetic risk associated with accumulative mutations are largely unknown. This study took advantage of published barley genomic data to predict sample-wise mutation burdens for 19,778 domesticated barley (Hordeum vulgare L.) accessions conserved ex situ. It was found that the conserved germplasm harbored 407 deleterious mutations and 337 (or 82%) identified deleterious alleles were present in 20 (or 0.1%) or fewer barley accessions. Analysis of the predicted mutation burdens revealed significant differences in mutation burden for several groups of barley germplasm (landrace > cultivar (or higher burden estimate in landrace than in cultivar); winter barley > spring barley; six-rowed barley > two-rowed barley; and 1000-accession core collection > non-core germplasm). Significant differences in burden estimate were also found among seven major geographical regions. The sample-wise predicted mutation burdens were positively correlated with the estimates of sample average pairwise genetic difference. These findings are significant for barley germplasm management and utilization and for a better understanding of the genetic risk in conserved plant germplasm.Long-term conservation of more than 7 million plant germplasm accessions in 1750 genebanks worldwide is a challenging mission. The extent of deleterious mutations present in conserved germplasm and the genetic risk associated with accumulative mutations are largely unknown. This study took advantage of published barley genomic data to predict sample-wise mutation burdens for 19,778 domesticated barley (Hordeum vulgare L.) accessions conserved ex situ. It was found that the conserved germplasm harbored 407 deleterious mutations and 337 (or 82%) identified deleterious alleles were present in 20 (or 0.1%) or fewer barley accessions. Analysis of the predicted mutation burdens revealed significant differences in mutation burden for several groups of barley germplasm (landrace > cultivar (or higher burden estimate in landrace than in cultivar); winter barley > spring barley; six-rowed barley > two-rowed barley; and 1000-accession core collection > non-core germplasm). Significant differences in burden estimate were also found among seven major geographical regions. The sample-wise predicted mutation burdens were positively correlated with the estimates of sample average pairwise genetic difference. These findings are significant for barley germplasm management and utilization and for a better understanding of the genetic risk in conserved plant germplasm. |
| Audience | Academic |
| Author | Fu, Yong-Bi |
| AuthorAffiliation | Plant Gene Resources of Canada, Saskatoon Research and Development Centre, Agriculture and Agri-Food Canada, 107 Science Place, Saskatoon, SK S7N 0X2, Canada; yong-bi.fu@agr.gc.ca |
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| Keywords | genotyping-by-sequencing mutation germplasm conservation germplasm management mutation burden barley germplasm |
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| References | Kono (ref_21) 2016; 33 Dourado (ref_7) 1984; 54 Schoen (ref_10) 1998; 95 ref_36 Hay (ref_37) 2021; 30 Pourkheirandish (ref_41) 2015; 162 Schoen (ref_3) 2001; 51 ref_11 Liu (ref_22) 2017; 34 Ng (ref_14) 2003; 31 Fu (ref_2) 2017; 57 Valluru (ref_23) 2019; 211 Gaut (ref_35) 2015; 31 Renaut (ref_20) 2015; 32 ref_39 ref_38 Cooper (ref_12) 2005; 15 Mizuta (ref_33) 2010; 107 Richards (ref_5) 2010; 50 Krishnan (ref_6) 2013; 60 Moyers (ref_24) 2017; 109 Kono (ref_30) 2019; 213 Schmid (ref_18) 2010; 121 Lu (ref_17) 2006; 22 ref_46 Milner (ref_16) 2019; 51 Bikard (ref_32) 2009; 323 ref_45 ref_44 Mezmouk (ref_19) 2014; 4 ref_43 Wang (ref_25) 2009; 10 Mascher (ref_42) 2017; 544 Chebotar (ref_4) 2003; 107 ref_1 Roles (ref_40) 2008; 62 Vaser (ref_27) 2015; 11 ref_29 ref_28 Fu (ref_34) 2012; 4 Charlesworth (ref_9) 1993; 61 ref_26 Ramu (ref_15) 2017; 49 ref_8 Salse (ref_31) 2008; 20 Fu (ref_47) 2006; 4 Henn (ref_13) 2015; 16 |
| References_xml | – volume: 10 start-page: 57 year: 2009 ident: ref_25 article-title: RNA-Seq: A revolutionary tool for transcriptomics publication-title: Nat. Rev. Genet. doi: 10.1038/nrg2484 – volume: 22 start-page: 126 year: 2006 ident: ref_17 article-title: The accumulation of deleterious mutations in rice genomes: A hypothesis on the cost of domestication publication-title: Trends Genet. doi: 10.1016/j.tig.2006.01.004 – volume: 211 start-page: 1075 year: 2019 ident: ref_23 article-title: Deleterious mutation burden and its association with complex traits in Sorghum (Sorghum bicolor) publication-title: Genetics doi: 10.1534/genetics.118.301742 – volume: 4 start-page: 163 year: 2014 ident: ref_19 article-title: The pattern and distribution of deleterious mutations in maize publication-title: G3 Genes Genomes Genet. doi: 10.1534/g3.113.008870 – volume: 32 start-page: 2273 year: 2015 ident: ref_20 article-title: The accumulation of deleterious mutations as a consequence of domestication and improvement in sunflowers and other Compositae crops publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msv106 – ident: ref_44 doi: 10.1007/978-1-4939-6658-5 – ident: ref_11 – volume: 107 start-page: 20417 year: 2010 ident: ref_33 article-title: Rice pollen hybrid incompatibility caused by reciprocal gene loss of duplicated genes publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1003124107 – ident: ref_43 doi: 10.1186/s13059-016-0974-4 – ident: ref_39 – volume: 15 start-page: 901 year: 2005 ident: ref_12 article-title: Distribution and intensity of constraint in mammalian genomic sequence publication-title: Genome Res. doi: 10.1101/gr.3577405 – volume: 33 start-page: 2307 year: 2016 ident: ref_21 article-title: The role of deleterious substitutions in crop genomes publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msw102 – ident: ref_26 doi: 10.1002/csc2.21325 – volume: 30 start-page: 100557 year: 2021 ident: ref_37 article-title: CGIAR genebank viability data reveal inconsistencies in seed collection management publication-title: Glob. Food Sec. doi: 10.1016/j.gfs.2021.100557 – volume: 51 start-page: 319 year: 2019 ident: ref_16 article-title: Genebank genomics highlights the diversity of a global barley collection publication-title: Nat. Genet. doi: 10.1038/s41588-018-0266-x – volume: 62 start-page: 1066 year: 2008 ident: ref_40 article-title: Fitness effects of mutation accumulation in a natural outbred population of wild radish (Raphanus raphanistrum): Comparison of field and greenhouse environments publication-title: Evolution doi: 10.1111/j.1558-5646.2008.00354.x – volume: 162 start-page: 527 year: 2015 ident: ref_41 article-title: Evolution of the grain dispersal system in barley publication-title: Cell doi: 10.1016/j.cell.2015.07.002 – volume: 107 start-page: 1469 year: 2003 ident: ref_4 article-title: Molecular studies on genetic integrity of open-pollinating species rye (Secale cereale L.) after long-term genebank maintenance publication-title: Theor. Appl. Genet. doi: 10.1007/s00122-003-1366-1 – ident: ref_1 – volume: 4 start-page: 117 year: 2006 ident: ref_47 article-title: Redundancy and distinctness in flax germplasm as revealed by RAPD dissimilarity publication-title: Plant Gen. Res. doi: 10.1079/PGR2005106 – volume: 109 start-page: 103 year: 2017 ident: ref_24 article-title: Genetic costs of domestication and improvement publication-title: J. Hered. doi: 10.1093/jhered/esx069 – ident: ref_29 doi: 10.3390/plants12071476 – volume: 20 start-page: 11 year: 2008 ident: ref_31 article-title: Identification and characterization of shared duplications between rice and wheat provide new insight into grass genome evolution publication-title: Plant Cell doi: 10.1105/tpc.107.056309 – volume: 61 start-page: 39 year: 1993 ident: ref_9 article-title: Mutation accumulation in finite outbreeding and inbreeding populations publication-title: Genet. Res. doi: 10.1017/S0016672300031086 – volume: 16 start-page: 333 year: 2015 ident: ref_13 article-title: Estimating the mutation load in human genomes publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3931 – ident: ref_28 doi: 10.1371/journal.pcbi.1001025 – volume: 54 start-page: 781 year: 1984 ident: ref_7 article-title: Phenotypic mutations induced during storage in barley and pea seeds publication-title: Ann. Bot. doi: 10.1093/oxfordjournals.aob.a086850 – volume: 50 start-page: 2440 year: 2010 ident: ref_5 article-title: Modeling demographics and genetic diversity in ex situ collections during seed storage and regeneration publication-title: Crop Sci. doi: 10.2135/cropsci2010.04.0236 – ident: ref_36 doi: 10.3390/plants12183186 – ident: ref_45 doi: 10.1186/s13059-017-1346-4 – volume: 121 start-page: 157 year: 2010 ident: ref_18 article-title: Deleterious amino acid polymorphisms in Arabidopsis thaliana and rice publication-title: Theor. Appl. Genet. doi: 10.1007/s00122-010-1299-4 – ident: ref_8 doi: 10.1093/molbev/msad238 – volume: 31 start-page: 3812 year: 2003 ident: ref_14 article-title: SIFT: Predicting amino acid changes that affect protein function publication-title: Nucl. Acids Res. doi: 10.1093/nar/gkg509 – volume: 34 start-page: 908 year: 2017 ident: ref_22 article-title: Deleterious variants in Asian rice and the potential cost of domestication publication-title: Mol. Biol. Evol. – ident: ref_46 – volume: 49 start-page: 959 year: 2017 ident: ref_15 article-title: Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation publication-title: Nat. Genet. doi: 10.1038/ng.3845 – volume: 95 start-page: 394 year: 1998 ident: ref_10 article-title: Deleterious mutation accumulation and the regeneration of genetic resources publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.1.394 – volume: 4 start-page: 239 year: 2012 ident: ref_34 article-title: Genetic diversity in a core subset of wild barley germplasm publication-title: Diversity doi: 10.3390/d4020239 – volume: 544 start-page: 427 year: 2017 ident: ref_42 article-title: A chromosome conformation capture ordered sequence of the barley genome publication-title: Nature doi: 10.1038/nature22043 – volume: 51 start-page: 960 year: 2001 ident: ref_3 article-title: The conservation of wild plant species in seed banks publication-title: BioScience doi: 10.1641/0006-3568(2001)051[0960:TCOWPS]2.0.CO;2 – volume: 57 start-page: 2314 year: 2017 ident: ref_2 article-title: The vulnerability of plant genetic resources conserved ex situ publication-title: Crop Sci. doi: 10.2135/cropsci2017.01.0014 – ident: ref_38 – volume: 213 start-page: 1531 year: 2019 ident: ref_30 article-title: The fate of deleterious variants in a barley genomic prediction population publication-title: Genetics doi: 10.1534/genetics.119.302733 – volume: 11 start-page: 1 year: 2015 ident: ref_27 article-title: SIFT missense predictions for genomes publication-title: Nat. Protoc. doi: 10.1038/nprot.2015.123 – volume: 31 start-page: 709 year: 2015 ident: ref_35 article-title: Genomics and the contrasting dynamics of annual and perennial domestication publication-title: Trends Genet. doi: 10.1016/j.tig.2015.10.002 – volume: 60 start-page: 1021 year: 2013 ident: ref_6 article-title: An assessment of the genetic integrity of ex situ germplasm collections of three endangered species of Coffea from Madagascar: Implications for the management of field germplasm collections publication-title: Genet. Resour. Crop Evol. doi: 10.1007/s10722-012-9898-3 – volume: 323 start-page: 623 year: 2009 ident: ref_32 article-title: Divergent evolution of duplicate genes leads to genetic incompatibilities within A. thaliana publication-title: Science doi: 10.1126/science.1165917 |
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| SubjectTerms | Alleles Analysis Barley Domestication Estimates Genome, Plant Genomes Genotype & phenotype Germplasm Hordeum - genetics Mutation |
| Title | Patterns of the Predicted Mutation Burden in 19,778 Domesticated Barley Accessions Conserved Ex Situ |
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