Patterns of the Predicted Mutation Burden in 19,778 Domesticated Barley Accessions Conserved Ex Situ

Long-term conservation of more than 7 million plant germplasm accessions in 1750 genebanks worldwide is a challenging mission. The extent of deleterious mutations present in conserved germplasm and the genetic risk associated with accumulative mutations are largely unknown. This study took advantage...

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Veröffentlicht in:International journal of molecular sciences Jg. 25; H. 11; S. 5930
1. Verfasser: Fu, Yong-Bi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 01.06.2024
MDPI
Schlagworte:
Alleles
Analysis
Barley
Domestication
Estimates
Genome, Plant
Genomes
Genotype & phenotype
Germplasm
Hordeum - genetics
Mutation
genotyping-by-sequencing
mutation
germplasm conservation
germplasm management
mutation burden
barley germplasm
ISSN:1422-0067, 1661-6596, 1422-0067
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Zusammenfassung:Long-term conservation of more than 7 million plant germplasm accessions in 1750 genebanks worldwide is a challenging mission. The extent of deleterious mutations present in conserved germplasm and the genetic risk associated with accumulative mutations are largely unknown. This study took advantage of published barley genomic data to predict sample-wise mutation burdens for 19,778 domesticated barley (Hordeum vulgare L.) accessions conserved ex situ. It was found that the conserved germplasm harbored 407 deleterious mutations and 337 (or 82%) identified deleterious alleles were present in 20 (or 0.1%) or fewer barley accessions. Analysis of the predicted mutation burdens revealed significant differences in mutation burden for several groups of barley germplasm (landrace > cultivar (or higher burden estimate in landrace than in cultivar); winter barley > spring barley; six-rowed barley > two-rowed barley; and 1000-accession core collection > non-core germplasm). Significant differences in burden estimate were also found among seven major geographical regions. The sample-wise predicted mutation burdens were positively correlated with the estimates of sample average pairwise genetic difference. These findings are significant for barley germplasm management and utilization and for a better understanding of the genetic risk in conserved plant germplasm.
Bibliographie:ObjectType-Article-1
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25115930