3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase as the gatekeeper of plant aromatic natural product biosynthesis

The shikimate pathway connects the central carbon metabolism with the biosynthesis of aromatic amino acids—l-tyrosine, l-phenylalanine, and l-tryptophan—which play indispensable roles as precursors of numerous aromatic phytochemicals. Despite the importance of the shikimate pathway-derived products...

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Bibliographic Details
Published in:Current opinion in plant biology Vol. 67; p. 102219
Main Authors: Yokoyama, Ryo, Kleven, Bailey, Gupta, Anika, Wang, Yuer, Maeda, Hiroshi A.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.06.2022
Subjects:
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase
Allosteric regulation
Aromatic amino acids
biosynthesis
carbon metabolism
humans
phenylalanine
phytochemicals
Plant aromatic natural products
plant physiology
Primary metabolism
shikimate pathway
society
The shikimate pathway
DTT
Phe
DHS
ADT
Trp
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase
Primary metabolism
Aromatic amino acids
DAHP
TyrA
E4P
AAA
The shikimate pathway
PIF4/5
CM
Plant aromatic natural products
Tyr
CCA1
CS
TF
ODO1
Allosteric regulation
EPSPS
PAL
PEP
ISSN:1369-5266, 1879-0356, 1879-0356
Online Access:Get full text
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Summary:The shikimate pathway connects the central carbon metabolism with the biosynthesis of aromatic amino acids—l-tyrosine, l-phenylalanine, and l-tryptophan—which play indispensable roles as precursors of numerous aromatic phytochemicals. Despite the importance of the shikimate pathway-derived products for both plant physiology and human society, the regulatory mechanism of the shikimate pathway remains elusive. This review summarizes the recent progress and current understanding on the plant 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHP synthase or DHS) enzymes that catalyze the committed reaction of the shikimate pathway. We particularly focus on how the DHS activity is regulated in plants in comparison to those of microbes and discuss potential roles of DHS as the critical gatekeeper for the production of plant aromatic compounds.
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ISSN:1369-5266
1879-0356
1879-0356
DOI:10.1016/j.pbi.2022.102219