Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank

Abstract Background We examined whether the greater severity of coronavirus disease 2019 (COVID-19) amongst men and Black, Asian and Minority Ethnic (BAME) individuals is explained by cardiometabolic, socio-economic or behavioural factors. Methods We studied 4510 UK Biobank participants tested for C...

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Vydáno v:Journal of public health (Oxford, England) Ročník 42; číslo 3; s. 451 - 460
Hlavní autoři: Raisi-Estabragh, Zahra, McCracken, Celeste, Bethell, Mae S, Cooper, Jackie, Cooper, Cyrus, Caulfield, Mark J, Munroe, Patricia B, Harvey, Nicholas C, Petersen, Steffen E
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Oxford University Press 18.08.2020
Témata:
Adult
Aged
Asian People - statistics & numerical data
Betacoronavirus
Black People
Body Mass Index
Cardiovascular Diseases - epidemiology
Coronavirus Infections - epidemiology
COVID-19
Ethnicity - statistics & numerical data
Female
Humans
Male
Mental Disorders - epidemiology
Metabolic Diseases - epidemiology
Middle Aged
Minority Groups - statistics & numerical data
Pandemics
Pneumonia, Viral - epidemiology
Population Surveillance
SARS-CoV-2
Socioeconomic Factors
United Kingdom - epidemiology
White People - statistics & numerical data
United Kingdom
epidemiology
communicable diseases
public health
ISSN:1741-3842, 1741-3850, 1741-3850
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Shrnutí:Abstract Background We examined whether the greater severity of coronavirus disease 2019 (COVID-19) amongst men and Black, Asian and Minority Ethnic (BAME) individuals is explained by cardiometabolic, socio-economic or behavioural factors. Methods We studied 4510 UK Biobank participants tested for COVID-19 (positive, n = 1326). Multivariate logistic regression models including age, sex and ethnicity were used to test whether addition of (1) cardiometabolic factors [diabetes, hypertension, high cholesterol, prior myocardial infarction, smoking and body mass index (BMI)]; (2) 25(OH)-vitamin D; (3) poor diet; (4) Townsend deprivation score; (5) housing (home type, overcrowding) or (6) behavioural factors (sociability, risk taking) attenuated sex/ethnicity associations with COVID-19 status. Results There was over-representation of men and BAME ethnicities in the COVID-19 positive group. BAME individuals had, on average, poorer cardiometabolic profile, lower 25(OH)-vitamin D, greater material deprivation, and were more likely to live in larger households and in flats/apartments. Male sex, BAME ethnicity, higher BMI, higher Townsend deprivation score and household overcrowding were independently associated with significantly greater odds of COVID-19. The pattern of association was consistent for men and women; cardiometabolic, socio-demographic and behavioural factors did not attenuate sex/ethnicity associations. Conclusions In this study, sex and ethnicity differential pattern of COVID-19 was not adequately explained by variations in cardiometabolic factors, 25(OH)-vitamin D levels or socio-economic factors. Factors which underlie ethnic differences in COVID-19 may not be easily captured, and so investigation of alternative biological and genetic susceptibilities as well as more comprehensive assessment of the complex economic, social and behavioural differences should be prioritised.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1741-3842
1741-3850
1741-3850
DOI:10.1093/pubmed/fdaa095