IFITM knockout DF1 cells produce higher influenza and newcastle disease viral yields: a proof of concept for avian origin cell-based vaccine production

Vaccines remain essential for the control of infectious diseases during poultry production, especially in high density systems. Many of poultry vaccines are currently grown in embryonated chicken eggs (ECE) or egg derived primary cells. These systems can be relatively costly and present a potential...

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Bibliographic Details
Published in:	Vaccine Vol. 61; p. 127360
Main Authors:	Samy, Ahmed, Alber, Andreas, Fife, Mark, Hammond, John A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 13.08.2025 Elsevier Limited
Subjects:	Allergy and Immunology Animals Antigens, Differentiation - genetics Avian origin cell line Biohazards Cell culture Cell Line Cell lines Chick Embryo Chickens Cloning CRISPR CRISPR-Cas Systems Disease Egg based vaccine replacement Eggs Epidemics Fibroblasts Fibroblasts - virology Gene editing Gene Knockout Techniques Genes Genome editing Glycoproteins IFITM1 IFITM3 Infections Infectious diseases Infectivity Influenza Influenza A Influenza A virus - growth & development Influenza A virus - immunology Influenza in Birds - immunology Influenza in Birds - prevention & control Influenza Vaccines - immunology Interferon Interferon inducible transmembrane protein Localization Membrane Proteins - genetics Newcastle disease Newcastle Disease - immunology Newcastle Disease - prevention & control Newcastle disease virus - growth & development Newcastle disease virus - immunology Pandemics Poultry Poultry production Proteins Public health RNA-Binding Proteins - genetics Vaccines Viral infections Viral Vaccines - immunology Virus Replication Viruses United Kingdom > UK IFITM3 CRISPR Interferon inducible transmembrane protein Egg based vaccine replacement IFITM1 Avian origin cell line Gene editing
ISSN:	0264-410X, 1873-2518, 1873-2518
Online Access:	Get full text
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