Palmitic acid promotes endothelial-to-mesenchymal transition via activation of the cytosolic DNA-sensing cGAS-STING pathway

Elevated levels of plasma free fatty acids (FFAs) lead to endothelial dysfunction, a process that is involved in the pathogenesis of atherosclerosis. Endothelial-to-mesenchymal transformation (EndMT) has been reported to accelerate endothelial dysfunction during the process of atherosclerosis. Howev...

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Veröffentlicht in:	Archives of biochemistry and biophysics Jg. 727; S. 109321
Hauptverfasser:	Liu, Qian, Cheng, Zhe, Huang, Bi, Luo, Suxin, Guo, Yongzheng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 30.09.2022
Schlagworte:	Atherosclerosis biophysics cell viability cGAS-STING pathway DNA, Mitochondrial - metabolism Endothelial Cells - metabolism Endothelial-to-mesenchymal transformation genes Human aortic endothelial cells Humans inflammation interferons Interferons - pharmacology Membrane Proteins - metabolism migratory behavior nitric oxide Nucleotidyltransferases - metabolism oxidative stress Palmitic acid Palmitic Acid - pharmacology pathogenesis RNA interference Signal Transduction stress response Human aortic endothelial cells Endothelial-to-mesenchymal transformation Palmitic acid cGAS-STING pathway
ISSN:	0003-9861, 1096-0384, 1096-0384
Online-Zugang:	Volltext
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