Missed Opportunities to Diagnose Common Variable Immunodeficiency: a Population-Based Case–Control Study Identifying Indicator Diseases for Common Variable Immunodeficiency

Purpose Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as indicator conditions for CVID diagnosis. Methods In this nested case–control study, we iden...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of clinical immunology Vol. 43; no. 8; pp. 2104 - 2114
Main Authors:	Dahl, Christina, Petersen, Inge, Ilkjær, Frederik V., Westh, Lena, Katzenstein, Terese L., Hansen, Ann-Brit E., Nielsen, Thyge L., Larsen, Carsten S., Johansen, Isik S., Rasmussen, Line D.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.11.2023 Springer Nature B.V
Subjects:	antibodies Biomedical and Life Sciences Biomedicine Case-Control Studies Common variable immunodeficiency Common Variable Immunodeficiency - complications Common Variable Immunodeficiency - diagnosis Common Variable Immunodeficiency - epidemiology Denmark Diagnosis Disease Early Diagnosis Hospitals Humans Immune system Immunology immunosuppression Infectious Diseases Internal Medicine Lung diseases lungs Medical Microbiology Morbidity mortality Odds Ratio Original Article Patients Population studies Registries regression analysis Respiratory tract infection risk Denmark CVID PID diagnostic delay secondary health care indicators
ISSN:	0271-9142, 1573-2592, 1573-2592
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Purpose Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as indicator conditions for CVID diagnosis. Methods In this nested case–control study, we identified 128 cases diagnosed with CVID in Denmark (1999–2013) and 640 age-, gender-, and region-matched controls. We obtained data on diseases diagnosed at hospitals in the five years before CVID diagnosis from The National Hospital Registry. We grouped hospital diagnoses in 33 major disease categories and 210 subcategories. We used conditional logistic regression to calculate the odds ratios (OR) and 95% confidence intervals (CI) to estimate associations between disease exposure and subsequent CVID. Results During the five years preceding a CVID diagnosis, cases had four times as many hospital contacts as the controls ( p < 0.001). A diagnosis in 18 major disease categories showed a significant OR for subsequent diagnosis of CVID. The most substantial association with a subsequent CVID diagnosis was a diagnosis of lower respiratory tract infections (OR: 29.9; 95% CI: 14.2–63.2) and lung diseases (35.1; 15.0–82.5). We observed a similar association when we removed the last year before diagnosis from analysis and overall, in the years < 1, ≥ 1–3, and ≥ 3–5 before diagnosis, although the absolute number of exposures was small. Twenty-eight specific diseases displayed an at least 3-fold risk of subsequent CVID diagnosis. Conclusion Targeted screening for antibody deficiency in patients diagnosed with specific diseases associated with CVID may lead to earlier CVID diagnosis and treatment and thereby potentially reduced morbidity and mortality.
AbstractList	Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as indicator conditions for CVID diagnosis. In this nested case-control study, we identified 128 cases diagnosed with CVID in Denmark (1999-2013) and 640 age-, gender-, and region-matched controls. We obtained data on diseases diagnosed at hospitals in the five years before CVID diagnosis from The National Hospital Registry. We grouped hospital diagnoses in 33 major disease categories and 210 subcategories. We used conditional logistic regression to calculate the odds ratios (OR) and 95% confidence intervals (CI) to estimate associations between disease exposure and subsequent CVID. During the five years preceding a CVID diagnosis, cases had four times as many hospital contacts as the controls (p < 0.001). A diagnosis in 18 major disease categories showed a significant OR for subsequent diagnosis of CVID. The most substantial association with a subsequent CVID diagnosis was a diagnosis of lower respiratory tract infections (OR: 29.9; 95% CI: 14.2-63.2) and lung diseases (35.1; 15.0-82.5). We observed a similar association when we removed the last year before diagnosis from analysis and overall, in the years < 1, ≥ 1-3, and ≥ 3-5 before diagnosis, although the absolute number of exposures was small. Twenty-eight specific diseases displayed an at least 3-fold risk of subsequent CVID diagnosis. Targeted screening for antibody deficiency in patients diagnosed with specific diseases associated with CVID may lead to earlier CVID diagnosis and treatment and thereby potentially reduced morbidity and mortality. PURPOSE: Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as indicator conditions for CVID diagnosis. METHODS: In this nested case–control study, we identified 128 cases diagnosed with CVID in Denmark (1999–2013) and 640 age-, gender-, and region-matched controls. We obtained data on diseases diagnosed at hospitals in the five years before CVID diagnosis from The National Hospital Registry. We grouped hospital diagnoses in 33 major disease categories and 210 subcategories. We used conditional logistic regression to calculate the odds ratios (OR) and 95% confidence intervals (CI) to estimate associations between disease exposure and subsequent CVID. RESULTS: During the five years preceding a CVID diagnosis, cases had four times as many hospital contacts as the controls (p < 0.001). A diagnosis in 18 major disease categories showed a significant OR for subsequent diagnosis of CVID. The most substantial association with a subsequent CVID diagnosis was a diagnosis of lower respiratory tract infections (OR: 29.9; 95% CI: 14.2–63.2) and lung diseases (35.1; 15.0–82.5). We observed a similar association when we removed the last year before diagnosis from analysis and overall, in the years < 1, ≥ 1–3, and ≥ 3–5 before diagnosis, although the absolute number of exposures was small. Twenty-eight specific diseases displayed an at least 3-fold risk of subsequent CVID diagnosis. CONCLUSION: Targeted screening for antibody deficiency in patients diagnosed with specific diseases associated with CVID may lead to earlier CVID diagnosis and treatment and thereby potentially reduced morbidity and mortality. PurposeDelayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as indicator conditions for CVID diagnosis.MethodsIn this nested case–control study, we identified 128 cases diagnosed with CVID in Denmark (1999–2013) and 640 age-, gender-, and region-matched controls. We obtained data on diseases diagnosed at hospitals in the five years before CVID diagnosis from The National Hospital Registry. We grouped hospital diagnoses in 33 major disease categories and 210 subcategories. We used conditional logistic regression to calculate the odds ratios (OR) and 95% confidence intervals (CI) to estimate associations between disease exposure and subsequent CVID.ResultsDuring the five years preceding a CVID diagnosis, cases had four times as many hospital contacts as the controls (p < 0.001). A diagnosis in 18 major disease categories showed a significant OR for subsequent diagnosis of CVID. The most substantial association with a subsequent CVID diagnosis was a diagnosis of lower respiratory tract infections (OR: 29.9; 95% CI: 14.2–63.2) and lung diseases (35.1; 15.0–82.5). We observed a similar association when we removed the last year before diagnosis from analysis and overall, in the years < 1, ≥ 1–3, and ≥ 3–5 before diagnosis, although the absolute number of exposures was small. Twenty-eight specific diseases displayed an at least 3-fold risk of subsequent CVID diagnosis.ConclusionTargeted screening for antibody deficiency in patients diagnosed with specific diseases associated with CVID may lead to earlier CVID diagnosis and treatment and thereby potentially reduced morbidity and mortality. Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as indicator conditions for CVID diagnosis.PURPOSEDelayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as indicator conditions for CVID diagnosis.In this nested case-control study, we identified 128 cases diagnosed with CVID in Denmark (1999-2013) and 640 age-, gender-, and region-matched controls. We obtained data on diseases diagnosed at hospitals in the five years before CVID diagnosis from The National Hospital Registry. We grouped hospital diagnoses in 33 major disease categories and 210 subcategories. We used conditional logistic regression to calculate the odds ratios (OR) and 95% confidence intervals (CI) to estimate associations between disease exposure and subsequent CVID.METHODSIn this nested case-control study, we identified 128 cases diagnosed with CVID in Denmark (1999-2013) and 640 age-, gender-, and region-matched controls. We obtained data on diseases diagnosed at hospitals in the five years before CVID diagnosis from The National Hospital Registry. We grouped hospital diagnoses in 33 major disease categories and 210 subcategories. We used conditional logistic regression to calculate the odds ratios (OR) and 95% confidence intervals (CI) to estimate associations between disease exposure and subsequent CVID.During the five years preceding a CVID diagnosis, cases had four times as many hospital contacts as the controls (p < 0.001). A diagnosis in 18 major disease categories showed a significant OR for subsequent diagnosis of CVID. The most substantial association with a subsequent CVID diagnosis was a diagnosis of lower respiratory tract infections (OR: 29.9; 95% CI: 14.2-63.2) and lung diseases (35.1; 15.0-82.5). We observed a similar association when we removed the last year before diagnosis from analysis and overall, in the years < 1, ≥ 1-3, and ≥ 3-5 before diagnosis, although the absolute number of exposures was small. Twenty-eight specific diseases displayed an at least 3-fold risk of subsequent CVID diagnosis.RESULTSDuring the five years preceding a CVID diagnosis, cases had four times as many hospital contacts as the controls (p < 0.001). A diagnosis in 18 major disease categories showed a significant OR for subsequent diagnosis of CVID. The most substantial association with a subsequent CVID diagnosis was a diagnosis of lower respiratory tract infections (OR: 29.9; 95% CI: 14.2-63.2) and lung diseases (35.1; 15.0-82.5). We observed a similar association when we removed the last year before diagnosis from analysis and overall, in the years < 1, ≥ 1-3, and ≥ 3-5 before diagnosis, although the absolute number of exposures was small. Twenty-eight specific diseases displayed an at least 3-fold risk of subsequent CVID diagnosis.Targeted screening for antibody deficiency in patients diagnosed with specific diseases associated with CVID may lead to earlier CVID diagnosis and treatment and thereby potentially reduced morbidity and mortality.CONCLUSIONTargeted screening for antibody deficiency in patients diagnosed with specific diseases associated with CVID may lead to earlier CVID diagnosis and treatment and thereby potentially reduced morbidity and mortality. Purpose Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as indicator conditions for CVID diagnosis. Methods In this nested case–control study, we identified 128 cases diagnosed with CVID in Denmark (1999–2013) and 640 age-, gender-, and region-matched controls. We obtained data on diseases diagnosed at hospitals in the five years before CVID diagnosis from The National Hospital Registry. We grouped hospital diagnoses in 33 major disease categories and 210 subcategories. We used conditional logistic regression to calculate the odds ratios (OR) and 95% confidence intervals (CI) to estimate associations between disease exposure and subsequent CVID. Results During the five years preceding a CVID diagnosis, cases had four times as many hospital contacts as the controls ( p < 0.001). A diagnosis in 18 major disease categories showed a significant OR for subsequent diagnosis of CVID. The most substantial association with a subsequent CVID diagnosis was a diagnosis of lower respiratory tract infections (OR: 29.9; 95% CI: 14.2–63.2) and lung diseases (35.1; 15.0–82.5). We observed a similar association when we removed the last year before diagnosis from analysis and overall, in the years < 1, ≥ 1–3, and ≥ 3–5 before diagnosis, although the absolute number of exposures was small. Twenty-eight specific diseases displayed an at least 3-fold risk of subsequent CVID diagnosis. Conclusion Targeted screening for antibody deficiency in patients diagnosed with specific diseases associated with CVID may lead to earlier CVID diagnosis and treatment and thereby potentially reduced morbidity and mortality.
Author	Johansen, Isik S. Katzenstein, Terese L. Ilkjær, Frederik V. Westh, Lena Dahl, Christina Nielsen, Thyge L. Rasmussen, Line D. Larsen, Carsten S. Petersen, Inge Hansen, Ann-Brit E.
Author_xml	– sequence: 1 givenname: Christina orcidid: 0009-0002-0086-7563 surname: Dahl fullname: Dahl, Christina email: ch-cd@hotmail.dk organization: Department of Infectious Diseases, Odense University Hospital – sequence: 2 givenname: Inge surname: Petersen fullname: Petersen, Inge organization: Department of Infectious Diseases, Odense University Hospital – sequence: 3 givenname: Frederik V. surname: Ilkjær fullname: Ilkjær, Frederik V. organization: Department of Infectious Diseases, Odense University Hospital – sequence: 4 givenname: Lena surname: Westh fullname: Westh, Lena organization: Department of Infectious Diseases, Aarhus University Hospital – sequence: 5 givenname: Terese L. surname: Katzenstein fullname: Katzenstein, Terese L. organization: Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital – sequence: 6 givenname: Ann-Brit E. surname: Hansen fullname: Hansen, Ann-Brit E. organization: Department of Infectious Diseases, Hvidovre Hospital, Copenhagen University Hospital – sequence: 7 givenname: Thyge L. surname: Nielsen fullname: Nielsen, Thyge L. organization: Department of Pulmonary and Infectious Diseases, North Zealand Hospital – sequence: 8 givenname: Carsten S. surname: Larsen fullname: Larsen, Carsten S. organization: Department of Infectious Diseases, Aarhus University Hospital, International Center of Immunodeficiency Diseases, Aarhus University Hospital – sequence: 9 givenname: Isik S. surname: Johansen fullname: Johansen, Isik S. organization: Department of Infectious Diseases, Odense University Hospital – sequence: 10 givenname: Line D. surname: Rasmussen fullname: Rasmussen, Line D. organization: Department of Infectious Diseases, Odense University Hospital
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/37770805$$D View this record in MEDLINE/PubMed
BookMark	eNqFkktuFDEQhi0URCaBC7BAltiwafCz7WYHzWukoCDx2FqOu3rkqNsebPdidtyBe3AoToInkwgpi2Rjy9L3_1Xl-k_QUYgBEHpKyUtKiHqVKdFKNoTxhlDZkaZ7gFZUKt4w2bEjtCJM0aajgh2jk5wvCSG8ZfIROuZKKaKJXKE_n33OMODz7TamsgRfPGRcIn7n7SbEDLiP8xwD_mGTtxcT4PU8LyEOMHrnIbjda2zxl7hdJlt8DM1bu7fr6_n31-8-hpLihL-WZdjh9QCh-HHnwwavw-CdLTHVQhkqnfFYH_cVe4wejnbK8OT6PkXfP7z_1n9qzs4_rvs3Z40TkpVGSA0jWMVH6kSdU1YHOVJLhdPWkZYq2tqBaWBiIJoPmmpQFR8E47wTlJ-iFwffbYo_F8jFzD47mCYbIC7ZcCq5VERQcS_KtCJdxyTfuz6_hV7GJYU6SKU62rZ1X3vq2TW1XMwwmG3ys007c7O0CugD4FLMOcFonC9Xv1-S9ZOhxOzzYQ75MDUf5iofpqtSdkt6436niB9EucJhA-l_23eo_gHRIc-z
CitedBy_id	crossref_primary_10_1016_j_jaci_2025_02_032 crossref_primary_10_1007_s10875_024_01746_1
Cites_doi	10.2147/CLEP.S179083 10.3389/fimmu.2021.652487 10.5001/omj.2020.64 10.1002/iid3.833 10.3389/fimmu.2021.620709 10.1177/1403494810387965 10.3389/fimmu.2022.742530 10.1186/s13023-018-0941-0 10.1007/s12026-017-8907-1 10.1007/s10875-019-00666-9 10.1016/j.jaip.2015.07.025 10.1007/s10875-017-0404-8 10.1007/s10875-007-9075-1 10.1016/j.jaci.2013.12.1077 10.1111/sji.12551 10.1371/journal.pone.0032538 10.3389/fimmu.2020.00149 10.18176/jiaci.0388 10.3389/fimmu.2018.00694 10.1016/j.jaci.2004.01.761 10.3389/fimmu.2018.02031 10.3389/fimmu.2020.00982 10.1016/j.clim.2017.03.011 10.3389/fimmu.2022.1033666 10.1177/1403494811401482 10.1007/s10875-023-01598-1 10.1007/s12026-023-09365-5
ContentType	Journal Article
Copyright	The Author(s) 2023 2023. The Author(s). The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: The Author(s) 2023 – notice: 2023. The Author(s). – notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7T5 7X7 7XB 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 7S9 L.6
DOI	10.1007/s10875-023-01590-9
DatabaseName	Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central (via ProQuest) Natural Science Collection ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitleList	MEDLINE AGRICOLA ProQuest Central Student MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1573-2592
EndPage	2114
ExternalDocumentID	37770805 10_1007_s10875_023_01590_9
Genre	Journal Article
GeographicLocations	Denmark
GeographicLocations_xml	– name: Denmark
GrantInformation_xml	– fundername: Odense University Hospital
GroupedDBID	--- -4W -56 -5G -BR -EM -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 199 1N0 1SB 2.D 203 28- 29K 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67N 67Z 6NX 78A 7X7 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AAJSJ AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHVE ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACULB ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFFNX AFGCZ AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BPHCQ BSONS BVXVI C6C CAG CCPQU COF CS3 CSCUP D-I DDRTE DL5 DNIVK DPUIP EBD EBLON EBS EIOEI EJD EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS H13 HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAK LK8 LLZTM M1P M4Y M7P MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI RNS ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TEORI TSG TSK TSV TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW VVN W23 W48 WJK WK6 WK8 Y6R YLTOR Z45 Z7U Z82 Z87 Z8O Z8V Z91 ZGI ZMTXR ZOVNA ~EX ~KM AAPKM AAYXX ABBRH ABDBE ABEEZ ABFSG ACSTC ADHKG AEZWR AFDZB AFFHD AFGXO AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7T5 7XB 8FK AZQEC DWQXO GNUQQ H94 K9. PKEHL PQEST PQUKI PRINS 7X8 7S9 L.6 PUEGO
ID	FETCH-LOGICAL-c452t-458efea73f1c48055def5f1a14c8ac061716ad28e24d083d818e7a73d42339413
IEDL.DBID	RSV
ISICitedReferencesCount	2
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001076806500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0271-9142 1573-2592
IngestDate	Thu Oct 02 21:47:28 EDT 2025 Sun Nov 09 10:43:42 EST 2025 Mon Oct 06 17:23:38 EDT 2025 Thu Apr 03 07:09:03 EDT 2025 Sat Nov 29 05:00:11 EST 2025 Tue Nov 18 21:58:24 EST 2025 Fri Feb 21 02:44:41 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	8
Keywords	CVID PID diagnostic delay secondary health care indicators
Language	English
License	2023. The Author(s).
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c452t-458efea73f1c48055def5f1a14c8ac061716ad28e24d083d818e7a73d42339413
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0009-0002-0086-7563
OpenAccessLink	https://link.springer.com/10.1007/s10875-023-01590-9
PMID	37770805
PQID	2891662711
PQPubID	37573
PageCount	11
ParticipantIDs	proquest_miscellaneous_3153570414 proquest_miscellaneous_2870992531 proquest_journals_2891662711 pubmed_primary_37770805 crossref_citationtrail_10_1007_s10875_023_01590_9 crossref_primary_10_1007_s10875_023_01590_9 springer_journals_10_1007_s10875_023_01590_9
PublicationCentury	2000
PublicationDate	20231100 2023-11-00 2023-Nov 20231101
PublicationDateYYYYMMDD	2023-11-01
PublicationDate_xml	– month: 11 year: 2023 text: 20231100
PublicationDecade	2020
PublicationPlace	New York
PublicationPlace_xml	– name: New York – name: Netherlands
PublicationSubtitle	International Journal of Inborn Errors of Immunity and Related Diseases
PublicationTitle	Journal of clinical immunology
PublicationTitleAbbrev	J Clin Immunol
PublicationTitleAlternate	J Clin Immunol
PublicationYear	2023
Publisher	Springer US Springer Nature B.V
Publisher_xml	– name: Springer US – name: Springer Nature B.V
References	Zainaldain, Rizvi, Rafiemanesh, Alizadeh, Jamee, Mohammadi, Kiaee (CR24) 2020; 35 Modell, Quinn, Ginsberg, Gladue, Orange, Modell (CR29) 2017; 65 CR17 Nickelsen (CR30) 2001; 164 Gathmann, Mahlaoui, Gérard, Oksenhendler, Warnatz, Schulze (CR8) 2014; 134 Yazdani, Habibi, Sharifi, Azizi, Abolhassani, Olbrich, Aghamohammadi (CR4) 2020; 30 Quinti, Soresina, Spadaro, Martino, Donnanno, Agostini (CR11) 2007; 27 Lynge, Sandegaard, Rebolj (CR20) 2011; 39 Pedersen (CR19) 2011; 39 Janssen, van der Flier, de Vries (CR16) 2021; 12 Schmidt, Schmidt, Adelborg, Sundbøll, Laugesen, Ehrenstein (CR18) 2019; 11 Cabañero-Navalon, Garcia-Bustos, Nuñez-Beltran, Císcar Fernández, Mateu, Solanich (CR23) 2022; 13 CR3 Ziętkiewicz, Więsik-Szewczyk, Matyja-Bednarczyk, Napiórkowska-Baran, Zdrojewski, Jahnz-Różyk (CR12) 2020; 11 Bruns, Panagiota, von Hardenberg, Schmidt, Adriawan, Sogka (CR7) 2022; 13 Slade, Bosco, Binh Giang, Kruse, Stirling, Cameron (CR10) 2018; 9 Westh, Mogensen, Dalgaard, Bernth Jensen, Katzenstein, Hansen (CR2) 2017; 85 Søgaard, Lohse, Østergaard, Kronborg, Røge, Gerstoft (CR21) 2012; 7 Bonilla, Barlan, Chapel, Costa-Carvalho, Cunningham-Rundles, Morena (CR1) 2016; 4 Rider, Kutac, Hajjar, Scalchunes, Seeborg, Boyle, Orange (CR14) 2017; 37 CR26 Mohammadi, Yadegar, Mardani, Ayati, Abolhassani, Rezaei (CR25) 2023; 11 Cunningham-Rundles, Sidi, Estrella, Doucette (CR28) 2004; 113 CR22 Odnoletkova, Kindle, Quinti, Grimbacher, Knerr, Gathmann (CR13) 2018; 13 Ho, Cunningham-Rundles (CR6) 2020; 11 Ilkjær, Rasmussen, Martin-Iguacel, Westh, Katzenstein, Hansen (CR15) 2019; 39 Fioranelli, Bottaccioli, Bottaccioli, Bianchi, Rovesti, Roccia (CR27) 2018; 9 Mormile, Punziano, Riolo, Granata, Williams, de Paulis, Spadaro, Rossi (CR5) 2021; 12 Graziano, Pecoraro, Mormile, Quaremba, Genovese (CR9) 2017; 180 CB Pedersen (1590_CR19) 2011; 39 LMA Janssen (1590_CR16) 2021; 12 OS Søgaard (1590_CR21) 2012; 7 F Mohammadi (1590_CR25) 2023; 11 H Zainaldain (1590_CR24) 2020; 35 1590_CR26 1590_CR22 L Bruns (1590_CR7) 2022; 13 I Odnoletkova (1590_CR13) 2018; 13 B Gathmann (1590_CR8) 2014; 134 NL Rider (1590_CR14) 2017; 37 V Modell (1590_CR29) 2017; 65 FV Ilkjær (1590_CR15) 2019; 39 TN Nickelsen (1590_CR30) 2001; 164 FA Bonilla (1590_CR1) 2016; 4 E Lynge (1590_CR20) 2011; 39 M Fioranelli (1590_CR27) 2018; 9 CA Slade (1590_CR10) 2018; 9 I Mormile (1590_CR5) 2021; 12 C Cunningham-Rundles (1590_CR28) 2004; 113 1590_CR17 M Ziętkiewicz (1590_CR12) 2020; 11 R Yazdani (1590_CR4) 2020; 30 V Graziano (1590_CR9) 2017; 180 I Quinti (1590_CR11) 2007; 27 M Schmidt (1590_CR18) 2019; 11 HE Ho (1590_CR6) 2020; 11 1590_CR3 MD Cabañero-Navalon (1590_CR23) 2022; 13 L Westh (1590_CR2) 2017; 85
References_xml	– ident: CR22 – volume: 11 start-page: 563 year: 2019 end-page: 591 ident: CR18 article-title: The Danish health care system and epidemiological research: from health care contacts to database records publication-title: Clin Epidemiol doi: 10.2147/CLEP.S179083 – volume: 12 start-page: 652487 year: 2021 ident: CR5 article-title: Common variable immunodeficiency and autoimmune diseases: a retrospective study of 95 adult patients in a single tertiary care center publication-title: Front Immunol doi: 10.3389/fimmu.2021.652487 – volume: 35 start-page: e157 issue: 4 year: 2020 ident: CR24 article-title: Infectious complications reporting in common variable immunodeficiency: a systematic review and meta-analysis publication-title: Oman Med J doi: 10.5001/omj.2020.64 – volume: 11 start-page: e833 issue: 4 year: 2023 ident: CR25 article-title: Organ-based clues for diagnosis of inborn errors of immunity: A practical guide for clinicians publication-title: Immun Inflamm Dis doi: 10.1002/iid3.833 – volume: 12 start-page: 620709 year: 2021 ident: CR16 article-title: Lessons learned from the clinical presentation of common variable immunodeficiency disorders: a systematic review and meta-analysis publication-title: Front Immunol doi: 10.3389/fimmu.2021.620709 – volume: 39 start-page: 22 issue: 7 Suppl year: 2011 end-page: 25 ident: CR19 article-title: The Danish Civil Registration System publication-title: Scand J Public Health doi: 10.1177/1403494810387965 – volume: 13 start-page: 742530 year: 2022 ident: CR7 article-title: Common variable immunodeficiency-associated cancers: the role of clinical phenotypes, immunological and genetic factors publication-title: Front Immunol doi: 10.3389/fimmu.2022.742530 – volume: 13 start-page: 201 issue: 1 year: 2018 ident: CR13 article-title: The burden of common variable immunodeficiency disorders: a retrospective analysis of the European Society for Immunodeficiency (ESID) registry data publication-title: Orphanet J Rare Dis doi: 10.1186/s13023-018-0941-0 – volume: 65 start-page: 713 issue: 3 year: 2017 end-page: 720 ident: CR29 article-title: Modeling strategy to identify patients with primary immunodeficiency utilizing risk management and outcome measurement publication-title: Immunol Res doi: 10.1007/s12026-017-8907-1 – volume: 39 start-page: 641 issue: 7 year: 2019 end-page: 652 ident: CR15 article-title: How to identify common variable immunodeficiency patients earlier: general practice patterns publication-title: J Clin Immunol doi: 10.1007/s10875-019-00666-9 – volume: 4 start-page: 38 issue: 1 year: 2016 end-page: 59 ident: CR1 article-title: International consensus document (ICON): common variable immunodeficiency disorders publication-title: J Allergy Clin Immunol Pract doi: 10.1016/j.jaip.2015.07.025 – volume: 37 start-page: 461 issue: 5 year: 2017 end-page: 475 ident: CR14 article-title: Health-related quality of life in adult patients with common variable immunodeficiency disorders and impact of treatment publication-title: J Clin Immunol doi: 10.1007/s10875-017-0404-8 – volume: 27 start-page: 308 issue: 3 year: 2007 end-page: 316 ident: CR11 article-title: Italian primary immunodeficiency network. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency publication-title: J Clin Immunol doi: 10.1007/s10875-007-9075-1 – volume: 134 start-page: 116 issue: 1 year: 2014 end-page: 126 ident: CR8 article-title: Clinical picture and treatment of 2212 patients with common variable immunodeficiency publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2013.12.1077 – volume: 85 start-page: 450 issue: 6 year: 2017 end-page: 461 ident: CR2 article-title: Identification and characterization of a nationwide Danish adult common variable immunodeficiency cohort publication-title: Scand J Immunol doi: 10.1111/sji.12551 – volume: 7 start-page: e32538 issue: 3 year: 2012 ident: CR21 article-title: Morbidity and risk of subsequent diagnosis of HIV: a population based case control study identifying indicator diseases for HIV infection publication-title: PloS One doi: 10.1371/journal.pone.0032538 – ident: CR3 – ident: CR17 – volume: 11 start-page: 149 year: 2020 ident: CR6 article-title: Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis publication-title: Front Immunol doi: 10.3389/fimmu.2020.00149 – volume: 30 start-page: 14 issue: 1 year: 2020 end-page: 34 ident: CR4 article-title: Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management publication-title: J Investig Allergol Clin Immunol doi: 10.18176/jiaci.0388 – volume: 9 start-page: 694 year: 2018 ident: CR10 article-title: Delayed diagnosis and complications of predominantly antibody deficiencies in a cohort of Australian Adults publication-title: Front Immunol doi: 10.3389/fimmu.2018.00694 – volume: 113 start-page: 747 issue: 4 year: 2004 end-page: 755 ident: CR28 article-title: Identifying undiagnosed primary immunodeficiency diseases in minority subjects by using computer sorting of diagnosis codes publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2004.01.761 – volume: 9 start-page: 2031 year: 2018 ident: CR27 article-title: Stress and inflammation in coronary artery disease: a review psychoneuroendocrineimmunology-based publication-title: Front Immunol doi: 10.3389/fimmu.2018.02031 – volume: 11 start-page: 982 year: 2020 ident: CR12 article-title: Shorter diagnostic delay in Polish adult patients with common variable immunodeficiency and symptom onset after 1999 publication-title: Front Immunol doi: 10.3389/fimmu.2020.00982 – volume: 180 start-page: 1 year: 2017 end-page: 4 ident: CR9 article-title: Delay in diagnosis affects the clinical outcome in a cohort of CVID patients with marked reduction of iga serum levels publication-title: Clin Immunol doi: 10.1016/j.clim.2017.03.011 – ident: CR26 – volume: 13 start-page: 1033666 year: 2022 ident: CR23 article-title: Current clinical spectrum of common variable immunodeficiency in Spain: the multicentric nationwide GTEM-SEMI-CVID registry publication-title: Front Immunol doi: 10.3389/fimmu.2022.1033666 – volume: 39 start-page: 30 issue: 7 Suppl year: 2011 end-page: 33 ident: CR20 article-title: The Danish National Patient Register publication-title: Scand J Public Health doi: 10.1177/1403494811401482 – volume: 164 start-page: 33 issue: 1 year: 2001 end-page: 37 ident: CR30 article-title: Data validity and coverage in the Danish National Health Registry. A literature review publication-title: Ugeskr Laeger – volume: 30 start-page: 14 issue: 1 year: 2020 ident: 1590_CR4 publication-title: J Investig Allergol Clin Immunol doi: 10.18176/jiaci.0388 – volume: 11 start-page: 982 year: 2020 ident: 1590_CR12 publication-title: Front Immunol doi: 10.3389/fimmu.2020.00982 – ident: 1590_CR22 doi: 10.1007/s10875-023-01598-1 – volume: 9 start-page: 694 year: 2018 ident: 1590_CR10 publication-title: Front Immunol doi: 10.3389/fimmu.2018.00694 – volume: 12 start-page: 620709 year: 2021 ident: 1590_CR16 publication-title: Front Immunol doi: 10.3389/fimmu.2021.620709 – volume: 134 start-page: 116 issue: 1 year: 2014 ident: 1590_CR8 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2013.12.1077 – volume: 39 start-page: 30 issue: 7 Suppl year: 2011 ident: 1590_CR20 publication-title: Scand J Public Health doi: 10.1177/1403494811401482 – volume: 85 start-page: 450 issue: 6 year: 2017 ident: 1590_CR2 publication-title: Scand J Immunol doi: 10.1111/sji.12551 – volume: 39 start-page: 641 issue: 7 year: 2019 ident: 1590_CR15 publication-title: J Clin Immunol doi: 10.1007/s10875-019-00666-9 – volume: 11 start-page: 149 year: 2020 ident: 1590_CR6 publication-title: Front Immunol doi: 10.3389/fimmu.2020.00149 – volume: 13 start-page: 201 issue: 1 year: 2018 ident: 1590_CR13 publication-title: Orphanet J Rare Dis doi: 10.1186/s13023-018-0941-0 – ident: 1590_CR3 doi: 10.1007/s12026-023-09365-5 – volume: 180 start-page: 1 year: 2017 ident: 1590_CR9 publication-title: Clin Immunol doi: 10.1016/j.clim.2017.03.011 – volume: 39 start-page: 22 issue: 7 Suppl year: 2011 ident: 1590_CR19 publication-title: Scand J Public Health doi: 10.1177/1403494810387965 – ident: 1590_CR17 – volume: 12 start-page: 652487 year: 2021 ident: 1590_CR5 publication-title: Front Immunol doi: 10.3389/fimmu.2021.652487 – volume: 164 start-page: 33 issue: 1 year: 2001 ident: 1590_CR30 publication-title: Ugeskr Laeger – volume: 27 start-page: 308 issue: 3 year: 2007 ident: 1590_CR11 publication-title: J Clin Immunol doi: 10.1007/s10875-007-9075-1 – volume: 7 start-page: e32538 issue: 3 year: 2012 ident: 1590_CR21 publication-title: PloS One doi: 10.1371/journal.pone.0032538 – volume: 113 start-page: 747 issue: 4 year: 2004 ident: 1590_CR28 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2004.01.761 – volume: 65 start-page: 713 issue: 3 year: 2017 ident: 1590_CR29 publication-title: Immunol Res doi: 10.1007/s12026-017-8907-1 – volume: 9 start-page: 2031 year: 2018 ident: 1590_CR27 publication-title: Front Immunol doi: 10.3389/fimmu.2018.02031 – volume: 13 start-page: 742530 year: 2022 ident: 1590_CR7 publication-title: Front Immunol doi: 10.3389/fimmu.2022.742530 – volume: 37 start-page: 461 issue: 5 year: 2017 ident: 1590_CR14 publication-title: J Clin Immunol doi: 10.1007/s10875-017-0404-8 – volume: 13 start-page: 1033666 year: 2022 ident: 1590_CR23 publication-title: Front Immunol doi: 10.3389/fimmu.2022.1033666 – volume: 35 start-page: e157 issue: 4 year: 2020 ident: 1590_CR24 publication-title: Oman Med J doi: 10.5001/omj.2020.64 – ident: 1590_CR26 – volume: 4 start-page: 38 issue: 1 year: 2016 ident: 1590_CR1 publication-title: J Allergy Clin Immunol Pract doi: 10.1016/j.jaip.2015.07.025 – volume: 11 start-page: 563 year: 2019 ident: 1590_CR18 publication-title: Clin Epidemiol doi: 10.2147/CLEP.S179083 – volume: 11 start-page: e833 issue: 4 year: 2023 ident: 1590_CR25 publication-title: Immun Inflamm Dis doi: 10.1002/iid3.833
SSID	ssj0003625
Score	2.4027803
Snippet	Purpose Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during... Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient... PurposeDelayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during... PURPOSE: Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during...
SourceID	proquest pubmed crossref springer
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	2104
SubjectTerms	antibodies Biomedical and Life Sciences Biomedicine Case-Control Studies Common variable immunodeficiency Common Variable Immunodeficiency - complications Common Variable Immunodeficiency - diagnosis Common Variable Immunodeficiency - epidemiology Denmark Diagnosis Disease Early Diagnosis Hospitals Humans Immune system Immunology immunosuppression Infectious Diseases Internal Medicine Lung diseases lungs Medical Microbiology Morbidity mortality Odds Ratio Original Article Patients Population studies Registries regression analysis Respiratory tract infection risk
SummonAdditionalLinks	– databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NbtQwEB7RghAX_go0pVRG4tZaxIm9dnpBdKFqDy17aKveItdxpEoo2e4PEjfegffgoXgSZhxvVlXVcuhlL2snlsYz801mvhmAD6l1jlpx8UwLhQFK7rkdWMldKtyFLRSRPcOwCX18bM7Pi1H84DaNZZULmxgMddU6-kb-EQMDQc3Khfg0vuI0NYqyq3GExgo8pC4JeSjdG_WWGI1zKGHEXajUMoukmUidQ6TO0WNhMK2KlBfXHdMNtHkjUxoc0P6z-x79OTyN0JN97u7KC3jgm5fw-Cgm19fgzxHl5iv2bUyYfN6EXqts1rIvXTmeZ8QmaRt2hvE1Ma7YIZFL2spTFwqicO4yy0b9RDC-Z-lxQ_z9--v3sKuJZ1S4-JN1_ODAsWKHDeWKMPbHF4Vs0ZQhkv7vy17B6f7Xk-EBj-McuJMqm3GpjK-91XktnDSpUrhD1cIK6Yx1BKXEwFaZ8ZmsEBhWCCW8xuUVIr68QGf7GlabtvHrwAa4SaW18XmBXrg2BcKorDYD4y5ChJqAWMiydLHXOY3c-F4uuzST_EuUfxnkXxYJbPd7xl2njztXby5kXUatn5ZLQSfwvv8b9ZWSMLbx7ZzWaATlGZq-29fkeJWVTqWQCbzprl9_pFxrjShfJbCzuI_LA9x-3o27z_sWnmSkC4FkuQmrs8ncv4NH7sfscjrZClr1DzwlKEI priority: 102 providerName: ProQuest
Title	Missed Opportunities to Diagnose Common Variable Immunodeficiency: a Population-Based Case–Control Study Identifying Indicator Diseases for Common Variable Immunodeficiency
URI	https://link.springer.com/article/10.1007/s10875-023-01590-9 https://www.ncbi.nlm.nih.gov/pubmed/37770805 https://www.proquest.com/docview/2891662711 https://www.proquest.com/docview/2870992531 https://www.proquest.com/docview/3153570414
Volume	43
WOSCitedRecordID	wos001076806500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1573-2592 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0003625 issn: 0271-9142 databaseCode: M7P dateStart: 20230101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1573-2592 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0003625 issn: 0271-9142 databaseCode: 7X7 dateStart: 20230101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1573-2592 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0003625 issn: 0271-9142 databaseCode: BENPR dateStart: 20230101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1573-2592 dateEnd: 20231231 omitProxy: false ssIdentifier: ssj0003625 issn: 0271-9142 databaseCode: 8C1 dateStart: 20230101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1573-2592 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003625 issn: 0271-9142 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NTtwwEB4VqKpeWkpL2RZWRuLWWooTe-30VragcmC7goL2FhnHkZBQgthdJG68Q9-jD9Un6YzzQxE_VXvxJePYkmc832jmGwNsRdY5asXFYy0UBiiJ53ZgJXeRcCc2VUT2DI9N6NHITCbpuCGFTdtq9zYlGW7qP8huiK05-hgMf1Ua8XQBltDdGTLHg8Pj7v7FKzkULuLqaMoybqgy9__jtju6gzHv5EeD29l9-X8bXoYXDcxkn2u9eAVPfLkCz_abRPpr-LlPeficfTsn_D0vQ19VNqvYl7r0zjNijlQlO8ZYmthVbI-IJFXuqeME0TU_McvG3etffNvS74Y4_rr-Mazr3xkVKV6xmgsc-FRsr6S8EMb5uFDIDE0Zoua_LvYGjnZ3vg-_8ubpBu6kimdcKuMLb3VSCCdNpBTOUIWwQjpjHcEmMbB5bHwscwSBOcIGr1E8R3SXpOhYV2GxrEq_BmyAk1RUGJ-k6HELkyJkigszMO4kRKM9EO0JZq7pa07Pa5xlNx2Z6SAyPIgsHESW9uBDN-e87urxqPR6qxhZY-HTDANVQc3zBW5gs_uMtkkJF1v6ak4yGgF4jNfcwzIJuhylIylkD97WStdtKdFaI6JXPfjYatjNBh7e77t_E38Pz2NS0kCwXIfF2cXcb8BTdzk7nV70YUFPdBgNjmYo-rC0vTMaH_SpTHbcD7b3G2JPI3c
linkProvider	Springer Nature
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtNAEB6VgigX_guGAosEJ7Dwrr3xGgkhSKkatQk5lKo3s1mvpUqVHRIHlBvvwHv0oXgSZtY_EapaTj1wySVre-TM35eZbwbgRaCNoVFcvoi5RIASWl_3dOSbgJuJTiSRPd2yiXg0UkdHyXgNTlsuDLVVtj7ROeqsNPQf-RsEBpyGlXP-fvrNp61RVF1tV2jUarFnlz8Qss3fDbbx930pxM6ng_6u32wV8E0kReVHUtnc6jjMuYlUIGVmc5lzzSOjtKGIzns6E8qKKMP8JMOIZmM8nmHiESbo8_G-V-AqphFCuVbBcef5MRi4lkmUEp1IJBqSTkPVQ2TgY4RE8C6TwE_-DoRnstszlVkX8HZu_W-v6jbcbFJr9qG2hTuwZou7cH3YNA_cg9Mh9R5k7POUMMeicLNkWVWy7brd0DJiy5QFO9RolZMTywZEnilRnGPnAZdvmWbjbuOZ_1HT7fr4-fvnr37d88-oMXPJav6z45CxQUG1sKqc4YNcNWzOECn882H34culvK1NWC_Kwj4E1sOLZJArGyaYZeQqwTRR5KqnzMQhcA94qzupaWa500qRk3Q1hZr0LUV9S52-pYkHr7prpvUkkwtPb7W6lTZebZ6uFMuD593X6I-oyKQLWy7oTIygQ6BrP_9MiGFWxkHEIw8e1OreiRTGcYwoRnrwutX_lQDny_voYnmfwcbuwXA_3R-M9h7DDUF26AilW7BezRb2CVwz36vj-eyps2gGXy_bLv4AwwODvA
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtNAEB6Vgqpe-IcGCiwSnGBV79qbtZEQgoSIqDTkAKg3d7NeS5UqOyQOKDfegffgAXgcnoSZtZ0IVS2nHrjkkrU9cubvy8w3A_AkMNbSKC4utVAIUELHTddE3AbCTkyiiOzpl03o0Sg-PEzGG_Cr5cJQW2XrE72jzkpL_5HvITAQNKxciL28aYsY9wevpl84bZCiSmu7TqNWkX23_Ibwbf5y2Mff-qmUg7cfe-94s2GA20jJikcqdrkzOsyFjeJAqczlKhdGRDY2lqK76JpMxk5GGeYqGUY3p_F4hklImKD_x_tegss6RC0mlnpv3V6CgcG3T6LE6FAi2RB2GtoeogSO0RKBvEoCnvwdFE9luqeqtD74Da79z6_tOlxtUm72uraRG7DhipuwddA0FdyCnwfUk5CxD1PCIovCz5hlVcn6dRuiY8SiKQv22aC1Tk4cGxKppkRxjr1nXL5gho1Xm9D4G0O36-Hn7-8_ejUXgFHD5pLVvGjPLWPDgmpkVTnDB_kq2Zwhgvjnw27Dpwt5W3dgsygLtwOsixepII9dmGD2kccJpo8yj7uxnXhk3gHR6lFqmxnvtGrkJF1PpybdS1H3Uq97adKBZ6trpvWEk3NP77Z6ljbebp6ulawDj1dfo5-i4pMpXLmgMxrBiESXf_aZEMOv0kEkog7crVV_JVKotUZ0ozrwvLWFtQBny3vvfHkfwRaaQ_p-ONq_D9uSTNLzTHdhs5ot3AO4Yr9Wx_PZQ2_cDI4u2iz-AHqpjDI
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Missed+Opportunities+to+Diagnose+Common+Variable+Immunodeficiency%3A+a+Population-Based+Case%E2%80%93Control+Study+Identifying+Indicator+Diseases+for+Common+Variable+Immunodeficiency&rft.jtitle=Journal+of+clinical+immunology&rft.au=Dahl%2C+Christina&rft.au=Petersen%2C+Inge&rft.au=Ilkj%C3%A6r%2C+Frederik+V&rft.au=Westh%2C+Lena&rft.date=2023-11-01&rft.issn=0271-9142&rft.volume=43&rft.issue=8+p.2104-2114&rft.spage=2104&rft.epage=2114&rft_id=info:doi/10.1007%2Fs10875-023-01590-9&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0271-9142&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0271-9142&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0271-9142&client=summon