Acylcarnitines activate proinflammatory signaling pathways

Incomplete β-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that plasma concentrations of medium- and long-chain acylcarnitines (by-products of incomplete β-oxidation) are elevated in T2DM and insulin resista...

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Bibliographic Details
Published in:	American journal of physiology: endocrinology and metabolism Vol. 306; no. 12; p. E1378
Main Authors:	Rutkowsky, Jennifer M, Knotts, Trina A, Ono-Moore, Kikumi D, McCoin, Colin S, Huang, Shurong, Schneider, Dina, Singh, Shamsher, Adams, Sean H, Hwang, Daniel H
Format:	Journal Article
Language:	English
Published:	United States 15.06.2014
Subjects:	Animals Carnitine - analogs & derivatives Carnitine - metabolism Cell Line, Transformed Cell Line, Tumor Cyclooxygenase 2 - chemistry Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cytokines - secretion Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - metabolism Docosahexaenoic Acids - metabolism Enzyme Induction Gene Silencing Humans Macrophage Activation Macrophages - immunology Macrophages - metabolism Macrophages - secretion MAP Kinase Signaling System Mice Myeloid Differentiation Factor 88 - agonists Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Myristic Acids - metabolism Phosphorylation Protein Processing, Post-Translational Receptors, Pattern Recognition - agonists Receptors, Pattern Recognition - antagonists & inhibitors Receptors, Pattern Recognition - genetics Receptors, Pattern Recognition - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Toll-Like Receptor 2 - agonists Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism pattern recognition receptors acylcarnitine β-oxidation TLR inflammation
ISSN:	1522-1555, 1522-1555
Online Access:	Get more information
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