MicroRNA-218 inhibits the malignant phenotypes of glioma by modulating the TNC/AKT/AP-1/TGFβ1 feedback signaling loop

Gliomas are the most malignant and common tumors of the human brain, and the prognosis of glioma patients is extremely poor MicroRNAs (miRNAs or miRs) play critical roles in different types of cancer by performing post-transcriptional regulation of gene expression Although miR-218 has been demonstra...

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Bibliographic Details
Published in:	International journal of molecular medicine Vol. 48; no. 5
Main Authors:	Dang, Siwen, Zhang, Rui, Tian, Sijia, Hou, Peng, Li, Gang, Ji, Meiju
Format:	Journal Article
Language:	English
Published:	Greece D.A. Spandidos 01.11.2021 Spandidos Publications UK Ltd
Subjects:	AKT/activator protein 1/transforming growth factor β1 signaling axis Animals Apoptosis - genetics Biotechnology Brain cancer Cancer therapies Cell cycle Cell Cycle Checkpoints - genetics Cell Proliferation - genetics Down-Regulation - genetics Experiments Feedback, Physiological Flow cytometry Gene expression Gene Expression Regulation, Neoplastic Glioma Glioma - genetics Glioma - pathology Laboratory animals Male Mice microRNA-218 MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Phenotype Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Survival analysis Tenascin - metabolism tenascin C Transcription Factor AP-1 - metabolism Transforming Growth Factor beta1 - metabolism Tumorigenesis Tumors glioma AKT/activator protein 1/transforming growth factor β1 signaling axis tenascin C tumorigenesis microRNA‑218
ISSN:	1107-3756, 1791-244X, 1791-244X
Online Access:	Get full text
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