Human L1 Transposition Dynamics Unraveled with Functional Data Analysis

Long INterspersed Elements-1 (L1s) constitute >17% of the human genome and still actively transpose in it. Characterizing L1 transposition across the genome is critical for understanding genome evolution and somatic mutations. However, to date, L1 insertion and fixation patterns have not been stu...

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Vydané v:	Molecular biology and evolution Ročník 37; číslo 12; s. 3576 - 3600
Hlavní autori:	Chen, Di, Cremona, Marzia A, Qi, Zongtai, Mitra, Robi D, Chiaromonte, Francesca, Makova, Kateryna D
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Oxford University Press 16.12.2020
Predmet:	Biological Evolution Chromatin Data analysis Datasets Discoveries DNA methylation DNA Transposable Elements Functionals Functions (mathematics) Genome, Human Genomes Genomics Humans Insertion Long Interspersed Nucleotide Elements Mathematical functions Models, Genetic Mutagenesis Mutagenesis, Insertional Statistical methods Transposition transposition fixation integration LINE-1 transposable elements
ISSN:	0737-4038, 1537-1719, 1537-1719
On-line prístup:	Získať plný text
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