Going circular: history, present, and future of circRNAs in cancer

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally and post-transcriptionally and exhibit distinct tis...

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Vydáno v:Oncogene Ročník 42; číslo 38; s. 2783 - 2800
Hlavní autoři: Pisignano, Giuseppina, Michael, David C., Visal, Tanvi H., Pirlog, Radu, Ladomery, Michael, Calin, George A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 15.09.2023
Nature Publishing Group
Témata:
45/47
45/77
631/67/68
692/53/2421
Apoptosis
Biosynthesis
Cancer
Cell Biology
Cell division
Circular RNA
DNA methylation
Gene expression
Human Genetics
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Post-transcription
Review
Review Article
Tumorigenesis
ISSN:0950-9232, 1476-5594, 1476-5594
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Shrnutí:To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally and post-transcriptionally and exhibit distinct tissue- and development-specific expression patterns associated with a variety of normal and disease conditions, including cancer pathogenesis. Over the past years, due to their intrinsic stability and resistance to ribonucleases, particular attention has been drawn to their use as reliable diagnostic and prognostic biomarkers in cancer diagnosis, treatment, and prevention. However, there are some critical caveats to their utility in the clinic. Their circular shape limits their annotation and a complete functional elucidation is lacking. This makes their detection and biomedical application still challenging. Herein, we review the current knowledge of circRNA biogenesis and function, and of their involvement in tumorigenesis and potential utility in cancer-targeted therapy.
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ISSN:0950-9232
1476-5594
1476-5594
DOI:10.1038/s41388-023-02780-w