Frontline Science: COVID‐19 infection induces readily detectable morphologic and inflammation‐related phenotypic changes in peripheral blood monocytes

Excessive monocyte/macrophage activation with the development of a cytokine storm and subsequent acute lung injury, leading to acute respiratory distress syndrome (ARDS), is a feared consequence of infection with COVID‐19. The ability to recognize and potentially intervene early in those patients at...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 109; no. 1; pp. 13 - 22
Main Authors:	Zhang, Dan, Guo, Rui, Lei, Lei, Liu, Hongjuan, Wang, Yawen, Wang, Yili, Qian, Hongbo, Dai, Tongxin, Zhang, Tianxiao, Lai, Yanjun, Wang, Jingya, Liu, Zhiqiang, Chen, Tianyan, He, Aili, O'Dwyer, Michael, Hu, Jinsong
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.01.2021 John Wiley and Sons Inc
Subjects:	Adult Antigens, CD - blood Blood CD14 antigen CD16 antigen CD80 antigen Cell activation COVID-19 COVID-19 - blood COVID-19 - pathology Cytokine storm Cytokines - blood Female Flow Cytometry forward scatter Highlighted Humans Inflammation - blood Inflammation - pathology Macrophages Macrophages - metabolism Macrophages - pathology Male Middle Aged monocyte Monocytes Monocytes - metabolism Monocytes - pathology morphology Patients Peripheral blood Respiratory distress syndrome SARS-CoV-2 - metabolism Scattering Spotlight on Leading Edge Research Tumor necrosis factor-α Young Adult COVID-19 forward scatter monocyte flow cytometry morphology
ISSN:	0741-5400, 1938-3673, 1938-3673
Online Access:	Get full text
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