Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment

Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial c...

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Veröffentlicht in:	Current opinion in hematology Jg. 10; H. 6; S. 451
Hauptverfasser:	Wadleigh, Martha, Ho, Vincent, Momtaz, Parisa, Richardson, Paul
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2003
Schlagworte:	Endothelium, Vascular - pathology Hematopoietic Stem Cell Transplantation - adverse effects Hepatic Veno-Occlusive Disease - diagnosis Hepatic Veno-Occlusive Disease - drug therapy Hepatic Veno-Occlusive Disease - etiology Humans Risk Factors
ISSN:	1065-6251
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Beschreibung
Zusammenfassung:	Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1065-6251
DOI:	10.1097/00062752-200311000-00010