Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment
Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial c...
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| Published in: | Current opinion in hematology Vol. 10; no. 6; p. 451 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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United States
01.11.2003
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| ISSN: | 1065-6251 |
| Online Access: | Get more information |
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| Abstract | Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed. |
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| AbstractList | Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed. Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed.Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed. |
| Author | Momtaz, Parisa Wadleigh, Martha Ho, Vincent Richardson, Paul |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/14564177$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Endothelium, Vascular - pathology Hematopoietic Stem Cell Transplantation - adverse effects Hepatic Veno-Occlusive Disease - diagnosis Hepatic Veno-Occlusive Disease - drug therapy Hepatic Veno-Occlusive Disease - etiology Humans Risk Factors |
| Title | Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment |
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