Brugada syndrome and reduced right ventricular outflow tract conduction reserve: a final common pathway?

Brugada syndrome (BrS) was first described as a primary electrical disorder predisposing to the risk of sudden cardiac death and characterized by right precordial lead ST elevation. Early description of right ventricular structural abnormalities and of right ventricular outflow tract (RVOT) conducti...

Full description

Saved in:
Bibliographic Details
Published in:European heart journal Vol. 42; no. 11; p. 1073
Main Authors: Behr, Elijah R, Ben-Haim, Yael, Ackerman, Michael J, Krahn, Andrew D, Wilde, Arthur A M
Format: Journal Article
Language:English
Published: England 14.03.2021
Subjects:
Depolarization
Right ventricular outflow tract
Genetics
Brugada syndrome
ISSN:1522-9645, 1522-9645
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Brugada syndrome (BrS) was first described as a primary electrical disorder predisposing to the risk of sudden cardiac death and characterized by right precordial lead ST elevation. Early description of right ventricular structural abnormalities and of right ventricular outflow tract (RVOT) conduction delay in BrS patients set the stage for the current controversy over the pathophysiology underlying the syndrome: channelopathy or cardiomyopathy; repolarization or depolarization. This review examines the current understanding of the BrS substrate, its genetic and non-genetic basis, theories of pathophysiology, and the clinical implications thereof. We propose that the final common pathway for BrS could be viewed as a disease of 'reduced RVOT conduction reserve'.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:1522-9645
1522-9645
DOI:10.1093/eurheartj/ehaa1051