Association between periodontitis and common variants in the promoter of the interleukin-6 gene
We recently reported an association between interleukin-6 ( IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs wer...
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| Vydáno v: | Cytokine (Philadelphia, Pa.) Ročník 45; číslo 1; s. 50 - 54 |
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2009
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| ISSN: | 1043-4666, 1096-0023, 1096-0023 |
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| Abstract | We recently reported an association between interleukin-6 (
IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five
IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (
n
=
454) there were moderate associations for −1363T allele (
p
=
0.011) and for −174GG and −1363GG genotypes with diagnosis of periodontitis (respectively,
p
=
0.044, OR
=
1.6, 95% CI
=
1.0–2.4, and
p
=
0.017, OR
=
1.8, 95% CI
=
1.1–2.8, adjusted for age, gender and smoking). Haplotypes containing the −174G>C, −1363G>T and −1480C>G polymorphisms were associated with diagnosis of periodontitis (
p
=
0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and −1480C>G and −6106A>T SNPs (
p
=
0.007 and 0.010, respectively). Among Caucasians the genotypes
IL6 −1480 CC and −6106 TT increased the adjusted OR for LAgP (OR
=
3.09 and 2.27, respectively). This study supports the hypothesis that
IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes. |
|---|---|
| AbstractList | We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (n=454) there were moderate associations for -1363T allele (p=0.011) and for -174GG and -1363GG genotypes with diagnosis of periodontitis (respectively, p=0.044, OR=1.6, 95% CI=1.0-2.4, and p=0.017, OR=1.8, 95% CI=1.1-2.8, adjusted for age, gender and smoking). Haplotypes containing the -174G>C, -1363G>T and -1480C>G polymorphisms were associated with diagnosis of periodontitis (p=0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and -1480C>G and -6106A>T SNPs (p=0.007 and 0.010, respectively). Among Caucasians the genotypes IL6 -1480 CC and -6106 TT increased the adjusted OR for LAgP (OR=3.09 and 2.27, respectively). This study supports the hypothesis that IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes.We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (n=454) there were moderate associations for -1363T allele (p=0.011) and for -174GG and -1363GG genotypes with diagnosis of periodontitis (respectively, p=0.044, OR=1.6, 95% CI=1.0-2.4, and p=0.017, OR=1.8, 95% CI=1.1-2.8, adjusted for age, gender and smoking). Haplotypes containing the -174G>C, -1363G>T and -1480C>G polymorphisms were associated with diagnosis of periodontitis (p=0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and -1480C>G and -6106A>T SNPs (p=0.007 and 0.010, respectively). Among Caucasians the genotypes IL6 -1480 CC and -6106 TT increased the adjusted OR for LAgP (OR=3.09 and 2.27, respectively). This study supports the hypothesis that IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes. We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (n=454) there were moderate associations for -1363T allele (p=0.011) and for -174GG and -1363GG genotypes with diagnosis of periodontitis (respectively, p=0.044, OR=1.6, 95% CI=1.0-2.4, and p=0.017, OR=1.8, 95% CI=1.1-2.8, adjusted for age, gender and smoking). Haplotypes containing the -174G>C, -1363G>T and -1480C>G polymorphisms were associated with diagnosis of periodontitis (p=0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and -1480C>G and -6106A>T SNPs (p=0.007 and 0.010, respectively). Among Caucasians the genotypes IL6 -1480 CC and -6106 TT increased the adjusted OR for LAgP (OR=3.09 and 2.27, respectively). This study supports the hypothesis that IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes. We recently reported an association between interleukin-6 ( IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians ( n = 454) there were moderate associations for −1363T allele ( p = 0.011) and for −174GG and −1363GG genotypes with diagnosis of periodontitis (respectively, p = 0.044, OR = 1.6, 95% CI = 1.0–2.4, and p = 0.017, OR = 1.8, 95% CI = 1.1–2.8, adjusted for age, gender and smoking). Haplotypes containing the −174G>C, −1363G>T and −1480C>G polymorphisms were associated with diagnosis of periodontitis ( p = 0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and −1480C>G and −6106A>T SNPs ( p = 0.007 and 0.010, respectively). Among Caucasians the genotypes IL6 −1480 CC and −6106 TT increased the adjusted OR for LAgP (OR = 3.09 and 2.27, respectively). This study supports the hypothesis that IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes. |
| Author | Humphries, S.E. Parkar, M. Nibali, L. D’Aiuto, F. Brett, P.M. Donos, N. Griffiths, G.S. Tonetti, M.S. |
| Author_xml | – sequence: 1 givenname: L. surname: Nibali fullname: Nibali, L. email: l.nibali@eastman.ucl.ac.uk organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK – sequence: 2 givenname: F. surname: D’Aiuto fullname: D’Aiuto, F. organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK – sequence: 3 givenname: N. surname: Donos fullname: Donos, N. organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK – sequence: 4 givenname: G.S. surname: Griffiths fullname: Griffiths, G.S. organization: Department of Adult Dental Care, School of Clinical Dentistry, Sheffield, UK – sequence: 5 givenname: M. surname: Parkar fullname: Parkar, M. organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK – sequence: 6 givenname: M.S. surname: Tonetti fullname: Tonetti, M.S. organization: European Research Group on Periodontology (ERGOPerio), Berne, Switzerland – sequence: 7 givenname: S.E. surname: Humphries fullname: Humphries, S.E. organization: Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Royal Free and University College London Medical School, London WC1E 6JJ, UK – sequence: 8 givenname: P.M. surname: Brett fullname: Brett, P.M. organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19084430$$D View this record in MEDLINE/PubMed |
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| Keywords | Haplotypes Genetic Periodontitis Interleukin-6 Polymorphism |
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| Snippet | We recently reported an association between interleukin-6 (
IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study... We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study... |
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| SubjectTerms | Adult Aged Alleles Female Genetic Genetic Predisposition to Disease Genotype Haplotypes Humans Interleukin-6 Interleukin-6 - genetics Linkage Disequilibrium Male Middle Aged Periodontitis Periodontitis - genetics Polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic |
| Title | Association between periodontitis and common variants in the promoter of the interleukin-6 gene |
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