Association between periodontitis and common variants in the promoter of the interleukin-6 gene
We recently reported an association between interleukin-6 ( IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs wer...
Saved in:
| Published in: | Cytokine (Philadelphia, Pa.) Vol. 45; no. 1; pp. 50 - 54 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
2009
|
| Subjects: | |
| ISSN: | 1043-4666, 1096-0023, 1096-0023 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | We recently reported an association between interleukin-6 (
IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five
IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (
n
=
454) there were moderate associations for −1363T allele (
p
=
0.011) and for −174GG and −1363GG genotypes with diagnosis of periodontitis (respectively,
p
=
0.044, OR
=
1.6, 95% CI
=
1.0–2.4, and
p
=
0.017, OR
=
1.8, 95% CI
=
1.1–2.8, adjusted for age, gender and smoking). Haplotypes containing the −174G>C, −1363G>T and −1480C>G polymorphisms were associated with diagnosis of periodontitis (
p
=
0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and −1480C>G and −6106A>T SNPs (
p
=
0.007 and 0.010, respectively). Among Caucasians the genotypes
IL6 −1480 CC and −6106 TT increased the adjusted OR for LAgP (OR
=
3.09 and 2.27, respectively). This study supports the hypothesis that
IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes. |
|---|---|
| AbstractList | We recently reported an association between interleukin-6 (
IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five
IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (
n
=
454) there were moderate associations for −1363T allele (
p
=
0.011) and for −174GG and −1363GG genotypes with diagnosis of periodontitis (respectively,
p
=
0.044, OR
=
1.6, 95% CI
=
1.0–2.4, and
p
=
0.017, OR
=
1.8, 95% CI
=
1.1–2.8, adjusted for age, gender and smoking). Haplotypes containing the −174G>C, −1363G>T and −1480C>G polymorphisms were associated with diagnosis of periodontitis (
p
=
0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and −1480C>G and −6106A>T SNPs (
p
=
0.007 and 0.010, respectively). Among Caucasians the genotypes
IL6 −1480 CC and −6106 TT increased the adjusted OR for LAgP (OR
=
3.09 and 2.27, respectively). This study supports the hypothesis that
IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes. We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (n=454) there were moderate associations for -1363T allele (p=0.011) and for -174GG and -1363GG genotypes with diagnosis of periodontitis (respectively, p=0.044, OR=1.6, 95% CI=1.0-2.4, and p=0.017, OR=1.8, 95% CI=1.1-2.8, adjusted for age, gender and smoking). Haplotypes containing the -174G>C, -1363G>T and -1480C>G polymorphisms were associated with diagnosis of periodontitis (p=0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and -1480C>G and -6106A>T SNPs (p=0.007 and 0.010, respectively). Among Caucasians the genotypes IL6 -1480 CC and -6106 TT increased the adjusted OR for LAgP (OR=3.09 and 2.27, respectively). This study supports the hypothesis that IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes.We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (n=454) there were moderate associations for -1363T allele (p=0.011) and for -174GG and -1363GG genotypes with diagnosis of periodontitis (respectively, p=0.044, OR=1.6, 95% CI=1.0-2.4, and p=0.017, OR=1.8, 95% CI=1.1-2.8, adjusted for age, gender and smoking). Haplotypes containing the -174G>C, -1363G>T and -1480C>G polymorphisms were associated with diagnosis of periodontitis (p=0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and -1480C>G and -6106A>T SNPs (p=0.007 and 0.010, respectively). Among Caucasians the genotypes IL6 -1480 CC and -6106 TT increased the adjusted OR for LAgP (OR=3.09 and 2.27, respectively). This study supports the hypothesis that IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes. We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 subjects (167 generalized aggressive periodontitis, 57 localized aggressive, 310 chronic periodontitis and 231 periodontally healthy). Among Caucasians (n=454) there were moderate associations for -1363T allele (p=0.011) and for -174GG and -1363GG genotypes with diagnosis of periodontitis (respectively, p=0.044, OR=1.6, 95% CI=1.0-2.4, and p=0.017, OR=1.8, 95% CI=1.1-2.8, adjusted for age, gender and smoking). Haplotypes containing the -174G>C, -1363G>T and -1480C>G polymorphisms were associated with diagnosis of periodontitis (p=0.02). Subgroup analysis by disease phenotype showed associations for the localized AgP (LAgP) group and -1480C>G and -6106A>T SNPs (p=0.007 and 0.010, respectively). Among Caucasians the genotypes IL6 -1480 CC and -6106 TT increased the adjusted OR for LAgP (OR=3.09 and 2.27, respectively). This study supports the hypothesis that IL6 polymorphisms and haplotypes are moderately associated with periodontitis, possibly acting through influencing tissue levels of IL6. This association is stronger for LAgP than for other periodontal disease phenotypes. |
| Author | Humphries, S.E. Parkar, M. Nibali, L. D’Aiuto, F. Brett, P.M. Donos, N. Griffiths, G.S. Tonetti, M.S. |
| Author_xml | – sequence: 1 givenname: L. surname: Nibali fullname: Nibali, L. email: l.nibali@eastman.ucl.ac.uk organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK – sequence: 2 givenname: F. surname: D’Aiuto fullname: D’Aiuto, F. organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK – sequence: 3 givenname: N. surname: Donos fullname: Donos, N. organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK – sequence: 4 givenname: G.S. surname: Griffiths fullname: Griffiths, G.S. organization: Department of Adult Dental Care, School of Clinical Dentistry, Sheffield, UK – sequence: 5 givenname: M. surname: Parkar fullname: Parkar, M. organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK – sequence: 6 givenname: M.S. surname: Tonetti fullname: Tonetti, M.S. organization: European Research Group on Periodontology (ERGOPerio), Berne, Switzerland – sequence: 7 givenname: S.E. surname: Humphries fullname: Humphries, S.E. organization: Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Royal Free and University College London Medical School, London WC1E 6JJ, UK – sequence: 8 givenname: P.M. surname: Brett fullname: Brett, P.M. organization: Periodontology Unit, University College London (UCL), Eastman Dental Institute, London, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19084430$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1LHTEUxUNR6kf7D3QhWbmb500yZibgRqRfILjRdcgkd2peZ5Jnkmfxv2_GZxG60FXuPfxOuJxzRPZCDEjIFwYrBkyerVf2qcQVB-irsKrSB3LIQMkGgIu9ZW5F00opD8hRzmsAUKLrPpIDpqBvWwGHRF_mHK03xcdAByx_EAPdYPLRxVB88Zma4KiN81yBR5O8CSVTH2i5R7pJcY4FE43j8-5DXSbc_vahkfQXBvxE9kczZfz88h6Tu29fb69-NNc3339eXV43tj1npcGe284CutEwA9YodFJxJ8TY10FY1XKJYLvBKeCjHEbFhAE1WMGHc9u34pic7v6tJz1sMRc9-2xxmkzAuM1ayq7rOFfvghxEL1vJKnjyAm6HGZ3eJD-b9KT_ZVcBvgNsijknHF8R0EtBeq2XgvRS0KJVqZr6_0zWl-f0SzJ-ett6sbNizfHRY9LZegwWnU9oi3bRv2X_Cy8SrTw |
| CitedBy_id | crossref_primary_10_1002_ajp_22376 crossref_primary_10_1099_jmm_0_012021_0 crossref_primary_10_1186_s40001_023_01273_6 crossref_primary_10_1038_gene_2011_28 crossref_primary_10_1155_2010_324719 crossref_primary_10_1016_j_cyto_2009_06_011 crossref_primary_10_1080_08820139_2018_1517365 crossref_primary_10_1002_JPER_20_0126 crossref_primary_10_1007_s00784_015_1551_z crossref_primary_10_1016_j_archoralbio_2010_04_001 crossref_primary_10_1902_jop_2017_160553 crossref_primary_10_1016_j_archoralbio_2019_03_015 crossref_primary_10_1093_humrep_des034 crossref_primary_10_1002_pros_22557 crossref_primary_10_1111_j_1600_051X_2009_01501_x crossref_primary_10_1111_j_1601_0825_2011_01867_x crossref_primary_10_1093_infdis_jis208 crossref_primary_10_3390_ani13152463 crossref_primary_10_1186_1479_5876_10_S1_S8 crossref_primary_10_1016_j_gene_2011_06_018 crossref_primary_10_1111_jre_12802 crossref_primary_10_1111_j_1600_051X_2012_01895_x crossref_primary_10_1590_S0074_02762012000900020 crossref_primary_10_1902_jop_2010_100513 crossref_primary_10_1016_j_job_2021_08_003 crossref_primary_10_3390_jcm9124045 crossref_primary_10_21101_cejph_a4656 crossref_primary_10_1111_j_1600_0501_2011_02329_x crossref_primary_10_1631_jzus_B0920279 crossref_primary_10_1902_jop_2012_120230 crossref_primary_10_1016_j_archoralbio_2018_08_007 crossref_primary_10_1016_j_bbrc_2009_11_084 crossref_primary_10_1155_2016_9612421 crossref_primary_10_1007_s11033_013_2621_4 crossref_primary_10_1111_prd_12021 crossref_primary_10_1002_JLB_4MA0720_698RR crossref_primary_10_1371_journal_pone_0087023 crossref_primary_10_1016_j_cden_2024_05_003 crossref_primary_10_3390_genes14051073 crossref_primary_10_1111_j_1600_0765_2011_01387_x crossref_primary_10_1016_j_humimm_2013_08_286 crossref_primary_10_1111_j_1600_0757_2011_00415_x crossref_primary_10_1111_j_1601_0825_2010_01731_x crossref_primary_10_1134_S1022795413010031 crossref_primary_10_1016_j_cyto_2011_03_006 crossref_primary_10_1111_j_1600_051X_2010_01648_x crossref_primary_10_1111_jcpe_12942 crossref_primary_10_1111_jre_12505 crossref_primary_10_1902_jop_2010_100054 crossref_primary_10_1111_jre_12389 crossref_primary_10_1111_jre_12784 crossref_primary_10_1111_prd_12357 crossref_primary_10_1007_s00784_012_0804_3 crossref_primary_10_1002_JPER_16_0712 crossref_primary_10_1111_odi_12352 crossref_primary_10_1186_s12903_019_0715_7 crossref_primary_10_2174_0109298673323591240923051742 crossref_primary_10_1111_odi_12075 crossref_primary_10_1016_j_archoralbio_2012_07_003 |
| Cites_doi | 10.1111/j.1365-2249.2007.03327.x 10.1111/j.1529-8817.2005.00225.x 10.1038/sj.gene.6364186 10.1373/clinchem.2007.097360 10.1111/j.1600-051X.1997.tb01187.x 10.1177/154405910708600505 10.1902/jop.2006.050058 10.1111/j.1600-051X.2007.01188.x 10.1093/hmg/ddl113 10.1034/j.1600-051X.2003.20016.x 10.1177/154405910508401211 10.1373/clinchem.2004.037531 10.1373/clinchem.2007.098608 10.1023/B:BEGE.0000013734.39266.a3 10.1902/annals.1999.4.1.53 10.1902/jop.2004.75.1.30 10.1111/j.1600-051X.2007.01067.x |
| ContentType | Journal Article |
| Copyright | 2008 Elsevier Ltd |
| Copyright_xml | – notice: 2008 Elsevier Ltd |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 8FD FR3 H94 P64 RC3 7X8 |
| DOI | 10.1016/j.cyto.2008.10.016 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts Genetics Abstracts Immunology Abstracts Engineering Research Database Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1096-0023 |
| EndPage | 54 |
| ExternalDocumentID | 19084430 10_1016_j_cyto_2008_10_016 S1043466608007734 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: British Heart Foundation grantid: RG/08/008/25291 – fundername: Department of Health |
| GroupedDBID | --- --K --M .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29F 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ 9JM AAAJQ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AAXUO ABBQC ABFNM ABFRF ABGSF ABJNI ABLJU ABLVK ABMAC ABMZM ABOCM ABUDA ABXDB ABYKQ ACDAQ ACGFO ACGFS ACRLP ADBBV ADEZE ADFGL ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGEKW AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 CAG CJTIS COF CS3 DM4 DOVZS DU5 EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDU HLW HMG HMK HMO HVGLF HX~ HZ~ IHE J1W KOM LCYCR LG5 LUGTX LX2 LZ5 M29 M41 MO0 N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SBG SCC SDF SDG SDP SES SEW SIN SPCBC SSH SSI SSU SSZ T5K TEORI UNMZH WUQ XPP ZMT ~G- 9DU AATTM AAXKI AAYWO AAYXX ACIEU ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AGCQF AGRNS CGR CUY CVF ECM EIF NPM 7T5 8FD FR3 H94 P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c451t-e82c7c0edfa1a0ca9ed692d33f8d693c9426e0c7bd902f6bf913a09bc32b5c843 |
| ISICitedReferencesCount | 68 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000262771200009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1043-4666 1096-0023 |
| IngestDate | Thu Oct 02 18:51:14 EDT 2025 Wed Oct 01 13:59:55 EDT 2025 Mon Jul 21 06:05:59 EDT 2025 Tue Nov 18 22:35:32 EST 2025 Sat Nov 29 05:37:11 EST 2025 Fri Feb 23 02:34:21 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Haplotypes Genetic Periodontitis Interleukin-6 Polymorphism |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c451t-e82c7c0edfa1a0ca9ed692d33f8d693c9426e0c7bd902f6bf913a09bc32b5c843 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 19084430 |
| PQID | 20386461 |
| PQPubID | 23462 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_66777229 proquest_miscellaneous_20386461 pubmed_primary_19084430 crossref_primary_10_1016_j_cyto_2008_10_016 crossref_citationtrail_10_1016_j_cyto_2008_10_016 elsevier_sciencedirect_doi_10_1016_j_cyto_2008_10_016 |
| PublicationCentury | 2000 |
| PublicationDate | 2009 2009-1-00 2009-Jan 20090101 |
| PublicationDateYYYYMMDD | 2009-01-01 |
| PublicationDate_xml | – year: 2009 text: 2009 |
| PublicationDecade | 2000 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Cytokine (Philadelphia, Pa.) |
| PublicationTitleAlternate | Cytokine |
| PublicationYear | 2009 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Sham, Rijsdijk, Knight, Makoff, North, Curtis (bib14) 2004; 34 Brett, Zygogianni, Griffiths, Tomaz, Parkar, D’Aiuto (bib8) 2005; 84 Wohfahrt, Wu, Hodges, Hinrichs, Michalowicz (bib17) 2006; 77 Tervonen, Raunio, Knuuttila, Karttunen (bib19) 2007; 34 Moreira, Lima, Sathler, Imanishi, Costa, Gomez (bib9) 2007; 148 Nibali, Ready, Parkar, Brett, Wilson, Tonetti (bib11) 2007; 86 Nibali, Griffiths, Donos, Parkar, D’Aiuto, Tonetti (bib10) 2008; 35 Park, Pillinger (bib1) 2007; 65 Smith, D’Aiuto, Palmen, Cooper, Samuel, Thompson (bib5) 2008 Fishman, Faulds, Jeffery, Mohammed-Ali, Humphries, Woo (bib3) 1998; 9 Fife, Ogilvie, Kelberman, Samuel, Gutierrez, Humphries (bib15) 2005; 6 Curtis, Knight, Sham (bib13) 2006; 70 Holla, Fassmann, Stejskalova, Znojil, Vanek, Vacha (bib18) 2004; 75 Packard, Libby (bib2) 2008; 54 Lang, Bartold, Cullinan, Jeffcoat, Mombelli, Murakami (bib12) 1999; 4 Qi, van Dam, Meigs, Manson, Hunter, Hu (bib16) 2006; 15 Kornman, Crane, Wang, diGiovine, Newman, Pirk (bib6) 1997; 24 Trevilatto, Scarel-Caminaga, de Brito, de Souza, Line (bib7) 2003; 30 Bennermo, Held, Stemme, Ericsson, Silveira, Green (bib4) 2004; 50 Sham (10.1016/j.cyto.2008.10.016_bib14) 2004; 34 Fife (10.1016/j.cyto.2008.10.016_bib15) 2005; 6 Wohfahrt (10.1016/j.cyto.2008.10.016_bib17) 2006; 77 Trevilatto (10.1016/j.cyto.2008.10.016_bib7) 2003; 30 Qi (10.1016/j.cyto.2008.10.016_bib16) 2006; 15 Nibali (10.1016/j.cyto.2008.10.016_bib10) 2008; 35 Packard (10.1016/j.cyto.2008.10.016_bib2) 2008; 54 Curtis (10.1016/j.cyto.2008.10.016_bib13) 2006; 70 Brett (10.1016/j.cyto.2008.10.016_bib8) 2005; 84 Moreira (10.1016/j.cyto.2008.10.016_bib9) 2007; 148 Tervonen (10.1016/j.cyto.2008.10.016_bib19) 2007; 34 Bennermo (10.1016/j.cyto.2008.10.016_bib4) 2004; 50 Nibali (10.1016/j.cyto.2008.10.016_bib11) 2007; 86 Fishman (10.1016/j.cyto.2008.10.016_bib3) 1998; 9 Lang (10.1016/j.cyto.2008.10.016_bib12) 1999; 4 Holla (10.1016/j.cyto.2008.10.016_bib18) 2004; 75 Smith (10.1016/j.cyto.2008.10.016_bib5) 2008 Park (10.1016/j.cyto.2008.10.016_bib1) 2007; 65 Kornman (10.1016/j.cyto.2008.10.016_bib6) 1997; 24 |
| References_xml | – volume: 54 start-page: 24 year: 2008 end-page: 38 ident: bib2 article-title: Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction publication-title: Clin Chem – volume: 50 start-page: 2136 year: 2004 end-page: 2140 ident: bib4 article-title: Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases? publication-title: Clin Chem – volume: 30 start-page: 438 year: 2003 end-page: 442 ident: bib7 article-title: Polymorphism at position-174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population publication-title: J Clin Periodontol – volume: 15 start-page: 1914 year: 2006 end-page: 1920 ident: bib16 article-title: Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis publication-title: Hum Mol Genet – year: 2008 ident: bib5 article-title: Serum levels of interleukin-6 (IL-6) are associated with a functional IL6-6331T>C polymorphism publication-title: Clin Chem – volume: 34 start-page: 207 year: 2004 end-page: 214 ident: bib14 article-title: Haplotype association analysis of discrete and continuous traits using mixture of regression models publication-title: Behav Genet – volume: 34 start-page: 377 year: 2007 end-page: 383 ident: bib19 article-title: Polymorphisms in the CD14 and IL-6 genes associated with periodontal disease publication-title: J Clin Periodontol – volume: 35 start-page: 193 year: 2008 end-page: 198 ident: bib10 article-title: Association between interleukin-6 promoter haplotypes and aggressive periodontitis publication-title: J Clin Periodontol – volume: 75 start-page: 30 year: 2004 end-page: 36 ident: bib18 article-title: Analysis of the interleukin-6 gene promoter polymorphisms in Czech patients with chronic periodontitis publication-title: J Periodontol – volume: 84 start-page: 1149 year: 2005 end-page: 1153 ident: bib8 article-title: Functional gene polymorphisms in aggressive and chronic periodontitis publication-title: J Dent Res – volume: 4 start-page: 53 year: 1999 ident: bib12 article-title: Consensus report: aggressive periodontitis publication-title: Ann Periodontol – volume: 65 start-page: S4 year: 2007 end-page: S10 ident: bib1 article-title: Interleukin-6 in the pathogenesis of rheumatoid arthritis publication-title: Bull NYU Hosp Jt Dis – volume: 24 start-page: 72 year: 1997 end-page: 77 ident: bib6 article-title: The interleukin-1 genotype as a severity factor in adult periodontal disease publication-title: J Clin Periodontol – volume: 9 start-page: 364 year: 1998 ident: bib3 article-title: An interleukin-6 promoter polymorphism that influences gene transcription, plasma IL-6 levels and is associated with systemic-onset juvenile chronic arthritis publication-title: Eur Cytokine Netw – volume: 86 start-page: 416 year: 2007 end-page: 420 ident: bib11 article-title: Gene polymorphisms and the prevalence of key periodontal pathogens publication-title: J Dent Res – volume: 148 start-page: 119 year: 2007 end-page: 126 ident: bib9 article-title: Interleukin-6 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals publication-title: Clin Exp Immunol – volume: 70 start-page: 277 year: 2006 end-page: 279 ident: bib13 article-title: Program report: GENECOUNTING support programs publication-title: Ann Hum Genet – volume: 77 start-page: 426 year: 2006 end-page: 436 ident: bib17 article-title: No association between selected candidate gene polymorphisms and severe chronic periodontitis publication-title: J Periodontol – volume: 6 start-page: 367 year: 2005 end-page: 370 ident: bib15 article-title: Novel IL-6 haplotypes and disease association publication-title: Genes Immun – volume: 148 start-page: 119 year: 2007 ident: 10.1016/j.cyto.2008.10.016_bib9 article-title: Interleukin-6 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2007.03327.x – volume: 9 start-page: 364 year: 1998 ident: 10.1016/j.cyto.2008.10.016_bib3 article-title: An interleukin-6 promoter polymorphism that influences gene transcription, plasma IL-6 levels and is associated with systemic-onset juvenile chronic arthritis publication-title: Eur Cytokine Netw – volume: 70 start-page: 277 year: 2006 ident: 10.1016/j.cyto.2008.10.016_bib13 article-title: Program report: GENECOUNTING support programs publication-title: Ann Hum Genet doi: 10.1111/j.1529-8817.2005.00225.x – volume: 6 start-page: 367 year: 2005 ident: 10.1016/j.cyto.2008.10.016_bib15 article-title: Novel IL-6 haplotypes and disease association publication-title: Genes Immun doi: 10.1038/sj.gene.6364186 – volume: 54 start-page: 24 year: 2008 ident: 10.1016/j.cyto.2008.10.016_bib2 article-title: Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction publication-title: Clin Chem doi: 10.1373/clinchem.2007.097360 – volume: 24 start-page: 72 year: 1997 ident: 10.1016/j.cyto.2008.10.016_bib6 article-title: The interleukin-1 genotype as a severity factor in adult periodontal disease publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.1997.tb01187.x – volume: 86 start-page: 416 year: 2007 ident: 10.1016/j.cyto.2008.10.016_bib11 article-title: Gene polymorphisms and the prevalence of key periodontal pathogens publication-title: J Dent Res doi: 10.1177/154405910708600505 – volume: 77 start-page: 426 year: 2006 ident: 10.1016/j.cyto.2008.10.016_bib17 article-title: No association between selected candidate gene polymorphisms and severe chronic periodontitis publication-title: J Periodontol doi: 10.1902/jop.2006.050058 – volume: 35 start-page: 193 year: 2008 ident: 10.1016/j.cyto.2008.10.016_bib10 article-title: Association between interleukin-6 promoter haplotypes and aggressive periodontitis publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2007.01188.x – volume: 15 start-page: 1914 year: 2006 ident: 10.1016/j.cyto.2008.10.016_bib16 article-title: Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis publication-title: Hum Mol Genet doi: 10.1093/hmg/ddl113 – volume: 30 start-page: 438 year: 2003 ident: 10.1016/j.cyto.2008.10.016_bib7 article-title: Polymorphism at position-174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population publication-title: J Clin Periodontol doi: 10.1034/j.1600-051X.2003.20016.x – volume: 84 start-page: 1149 year: 2005 ident: 10.1016/j.cyto.2008.10.016_bib8 article-title: Functional gene polymorphisms in aggressive and chronic periodontitis publication-title: J Dent Res doi: 10.1177/154405910508401211 – volume: 50 start-page: 2136 year: 2004 ident: 10.1016/j.cyto.2008.10.016_bib4 article-title: Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases? publication-title: Clin Chem doi: 10.1373/clinchem.2004.037531 – volume: 65 start-page: S4 issue: Suppl. 1 year: 2007 ident: 10.1016/j.cyto.2008.10.016_bib1 article-title: Interleukin-6 in the pathogenesis of rheumatoid arthritis publication-title: Bull NYU Hosp Jt Dis – year: 2008 ident: 10.1016/j.cyto.2008.10.016_bib5 article-title: Serum levels of interleukin-6 (IL-6) are associated with a functional IL6-6331T>C polymorphism publication-title: Clin Chem doi: 10.1373/clinchem.2007.098608 – volume: 34 start-page: 207 year: 2004 ident: 10.1016/j.cyto.2008.10.016_bib14 article-title: Haplotype association analysis of discrete and continuous traits using mixture of regression models publication-title: Behav Genet doi: 10.1023/B:BEGE.0000013734.39266.a3 – volume: 4 start-page: 53 year: 1999 ident: 10.1016/j.cyto.2008.10.016_bib12 article-title: Consensus report: aggressive periodontitis publication-title: Ann Periodontol doi: 10.1902/annals.1999.4.1.53 – volume: 75 start-page: 30 year: 2004 ident: 10.1016/j.cyto.2008.10.016_bib18 article-title: Analysis of the interleukin-6 gene promoter polymorphisms in Czech patients with chronic periodontitis publication-title: J Periodontol doi: 10.1902/jop.2004.75.1.30 – volume: 34 start-page: 377 year: 2007 ident: 10.1016/j.cyto.2008.10.016_bib19 article-title: Polymorphisms in the CD14 and IL-6 genes associated with periodontal disease publication-title: J Clin Periodontol doi: 10.1111/j.1600-051X.2007.01067.x |
| SSID | ssj0009377 |
| Score | 2.1689816 |
| Snippet | We recently reported an association between interleukin-6 (
IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study... We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 50 |
| SubjectTerms | Adult Aged Alleles Female Genetic Genetic Predisposition to Disease Genotype Haplotypes Humans Interleukin-6 Interleukin-6 - genetics Linkage Disequilibrium Male Middle Aged Periodontitis Periodontitis - genetics Polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic |
| Title | Association between periodontitis and common variants in the promoter of the interleukin-6 gene |
| URI | https://dx.doi.org/10.1016/j.cyto.2008.10.016 https://www.ncbi.nlm.nih.gov/pubmed/19084430 https://www.proquest.com/docview/20386461 https://www.proquest.com/docview/66777229 |
| Volume | 45 |
| WOSCitedRecordID | wos000262771200009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1096-0023 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0009377 issn: 1043-4666 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELe6DhAvCAZj5WP4gbcqVRIn_nis0MaHRDVpQ-pb5DiO6FalVddW2x-z_5VzbCftUCdA4iVKr07i-n61z5ff3SH0kSRFUoMX_tQ0SJguAxlFMuAF2CJ5mYZK5HWxCTYa8fFYnHU6dz4WZj1lVcVvbsT8v6oaZKBsEzr7F-pubgoCOAelwxHUDsc_UvzGgLcsLHgw7D_r_KnXPpQNetRfw1a5ZsI4uuO8ZufphacOmGwSi6leXU2qgJpyy9upDW6XsytnphrPjEk5Of9p6bdncrDhZRhNcukCsQeN7eyJFmI4WdXVnPqn7ZczRwAcNaLPzr9kffmD88GWx6KdEZsgmpaxZOZcQwBIKHUZsZ3McKNDG4rsJ2qbd3ILkHbWtalr3fptc1L_tjJYJ8XlQMHIWAqtIfVF99Jw1wv7uemR6ZCxphkjyR7aj1kqeBftD7-ejL-1WZ1JXdqz-QUuKssSCO8_aZfls2tnU1s4F8_RM7c1wUMLqReoo6sD9NgWK709QE--OxrGS5RtYAw7jOEtjGHAGLYYwx5jeFJhwBT2GMOzsv68hTFsMPYK_Tg9ufj0JXCVOgKVpNEy0DxWTIW6KGUkQyWFLqiIC0JKDidECbADdahYXogwLmEOEBGRocgVifNU8YQcom41q_QRwiySVFJCVVSWCdWwfdGCSq5kqhQty7SHIj-KmXJp7E01lWnm-YqXmRl5W18VZCDqoX5zzdwmcXmwdeqVkzkz1JqXGWDpwes-eE1mMEebF2-y0rPVNTQinCY02t2CUgbb3Fj00GsLgbafIuRJQsI3_9irt-ipfQFqvIbvUHe5WOn36JFaAxYWx2iPjfmxg_Uv1QDMYg |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+between+periodontitis+and+common+variants+in+the+promoter+of+the+interleukin-6+gene&rft.jtitle=Cytokine+%28Philadelphia%2C+Pa.%29&rft.au=Nibali%2C+L.&rft.au=D%E2%80%99Aiuto%2C+F.&rft.au=Donos%2C+N.&rft.au=Griffiths%2C+G.S.&rft.date=2009&rft.pub=Elsevier+Ltd&rft.issn=1043-4666&rft.eissn=1096-0023&rft.volume=45&rft.issue=1&rft.spage=50&rft.epage=54&rft_id=info:doi/10.1016%2Fj.cyto.2008.10.016&rft.externalDocID=S1043466608007734 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1043-4666&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1043-4666&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1043-4666&client=summon |