Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells

To identify therapeutic targets and prognostic markers for basal breast cancers, breast cancer cell lines were subjected to mass spectrometry-based profiling of protein tyrosine phosphorylation events. This revealed that luminal and basal breast cancer cells exhibit distinct tyrosine phosphorylation...

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Vydáno v:	Cancer research (Chicago, Ill.) Ročník 70; číslo 22; s. 9391
Hlavní autoři:	Hochgräfe, Falko, Zhang, Luxi, O'Toole, Sandra A, Browne, Brigid C, Pinese, Mark, Porta Cubas, Ana, Lehrbach, Gillian M, Croucher, David R, Rickwood, Danny, Boulghourjian, Alice, Shearer, Robert, Nair, Radhika, Swarbrick, Alexander, Faratian, Dana, Mullen, Peter, Harrison, David J, Biankin, Andrew V, Sutherland, Robert L, Raftery, Mark J, Daly, Roger J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.11.2010
Témata:	Animals Apoptosis - drug effects Blotting, Western Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Cluster Analysis Female Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans Kaplan-Meier Estimate Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mice Neoplasms, Basal Cell - genetics Neoplasms, Basal Cell - metabolism Neoplasms, Basal Cell - pathology Phosphoproteins - classification Phosphoproteins - metabolism Phosphorylation Protein Kinase Inhibitors - pharmacology Proteomics Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism RNA Interference Signal Transduction src-Family Kinases - genetics src-Family Kinases - metabolism Tyrosine - metabolism
ISSN:	1538-7445, 1538-7445
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