p53 methylation-the Arg-ument is clear

p53 activity is of critical importance in suppressing human cancer formation, highlighted by the fact that the majority of human tumours have defective or inactive p53. In normal cells, p53 is held at low levels in a latent form and, following DNA damage, is stabilized which usually results in apopt...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Vol. 8; no. 6; pp. 801 - 802
Main Authors: Durant, Stephen T., Cho, Er Chieh, La Thangue, Nicholas B.
Format: Journal Article
Language:English
Published: United States Taylor & Francis 15.03.2009
Subjects:
Animals
Arginine - metabolism
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
DNA Damage - physiology
Humans
Landes
Methylation
Neoplasms - metabolism
Organogenesis
Phosphorylation
Protein Methyltransferases - metabolism
Protein Processing, Post-Translational
Proteins
Tumor Suppressor Protein p53 - metabolism
ISSN:1538-4101, 1551-4005, 1551-4005
Online Access:Get full text
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Summary:p53 activity is of critical importance in suppressing human cancer formation, highlighted by the fact that the majority of human tumours have defective or inactive p53. In normal cells, p53 is held at low levels in a latent form and, following DNA damage, is stabilized which usually results in apoptosis or cell cycle arrest. Most functions of p53 can be ascribed to its role as a sequence specific transcription factor, and an extensive repertoire of downstream responsive genes have been identified. p53 activity is influenced by post-translational modifications, including phosphorylation and lysine methylation. Most recently, arginine methylation mediated by PRMT5, has been identified as an additional and important p53 modification. DNA damage induced p53 arginine methylation impacts on the biochemical properties and functional outcome of the p53 response.
Bibliography:ObjectType-Article-1
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ISSN:1538-4101
1551-4005
1551-4005
DOI:10.4161/cc.8.6.7850