Inferring cortical function in the mouse visual system through large-scale systems neuroscience

The scientific mission of the Project MindScope is to understand neocortex, the part of the mammalian brain that gives rise to perception, memory, intelligence, and consciousness. We seek to quantitatively evaluate the hypothesis that neocortex is a relatively homogeneous tissue, with smaller functi...

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Published in:Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 27; p. 7337
Main Authors: Hawrylycz, Michael, Anastassiou, Costas, Arkhipov, Anton, Berg, Jim, Buice, Michael, Cain, Nicholas, Gouwens, Nathan W, Gratiy, Sergey, Iyer, Ramakrishnan, Lee, Jung Hoon, Mihalas, Stefan, Mitelut, Catalin, Olsen, Shawn, Reid, R Clay, Teeter, Corinne, de Vries, Saskia, Waters, Jack, Zeng, Hongkui, Koch, Christof
Format: Journal Article
Language:English
Published: United States 05.07.2016
Subjects:
Animals
Male
Mice
Mice, Inbred C57BL
Models, Neurological
Neurons - physiology
Neurosciences - methods
Systems Analysis
Visual Cortex - physiology
visual system
neocortex
simulation
neural coding
computation
ISSN:1091-6490, 1091-6490
Online Access:Get more information
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Summary:The scientific mission of the Project MindScope is to understand neocortex, the part of the mammalian brain that gives rise to perception, memory, intelligence, and consciousness. We seek to quantitatively evaluate the hypothesis that neocortex is a relatively homogeneous tissue, with smaller functional modules that perform a common computational function replicated across regions. We here focus on the mouse as a mammalian model organism with genetics, physiology, and behavior that can be readily studied and manipulated in the laboratory. We seek to describe the operation of cortical circuitry at the computational level by comprehensively cataloging and characterizing its cellular building blocks along with their dynamics and their cell type-specific connectivities. The project is also building large-scale experimental platforms (i.e., brain observatories) to record the activity of large populations of cortical neurons in behaving mice subject to visual stimuli. A primary goal is to understand the series of operations from visual input in the retina to behavior by observing and modeling the physical transformations of signals in the corticothalamic system. We here focus on the contribution that computer modeling and theory make to this long-term effort.
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.1512901113