Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

In response to viral infection, cells mount a potent inflammatory response that relies on ISG15 and ubiquitin posttranslational modifications. Many viruses use deubiquitinases and deISGylases that reverse these modifications and antagonize host signaling processes. We here reveal that the leader pro...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 10; p. 2371
Main Authors:	Swatek, Kirby N, Aumayr, Martina, Pruneda, Jonathan N, Visser, Linda J, Berryman, Stephen, Kueck, Anja F, Geurink, Paul P, Ovaa, Huib, van Kuppeveld, Frank J M, Tuthill, Tobias J, Skern, Tim, Komander, David
Format:	Journal Article
Language:	English
Published:	United States 06.03.2018
Subjects:	Crystallography Cytokines - chemistry Cytokines - metabolism Endopeptidases - chemistry Endopeptidases - metabolism HeLa Cells Host-Pathogen Interactions Humans Models, Molecular Protein Binding Substrate Specificity Ubiquitin - metabolism Ubiquitins - chemistry Ubiquitins - metabolism FMDV viral signaling ISG15 structure ubiquitin
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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