Circulating tumor DNA status and dynamics predict recurrence in patients with resected extrahepatic cholangiocarcinoma

Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longi...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 82; no. 5; pp. 861 - 870
Main Authors:	Yoo, Changhoon, Jeong, Hyehyun, Jeong, Jae Ho, Kim, Kyu-pyo, Lee, Seonmin, Ryoo, Baek-Yeol, Hwang, Dae Wook, Lee, Jae Hoon, Moon, Deog-Bog, Kim, Ki-Hun, Lee, Sang Soo, Song, Tae Jun, Oh, Dongwook, Lee, Myung Ah, Chon, Hong Jae, Lee, Ji Sung, Laliotis, George, Rivero-Hinojosa, Samuel, Spickard, Erik, Renner, Derrick, Dutta, Punashi, Palsuledesai, Charuta C., Sharma, Shruti, Malhotra, Meenakshi, Jurdi, Adham, Liu, Minetta C.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2025
Subjects:	adjuvant capecitabine Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bile Duct Neoplasms - blood Bile Duct Neoplasms - drug therapy Bile Duct Neoplasms - surgery Biomarkers, Tumor - blood Capecitabine - administration & dosage Capecitabine - therapeutic use Chemotherapy, Adjuvant - methods Cholangiocarcinoma - blood Cholangiocarcinoma - drug therapy Cholangiocarcinoma - genetics Cholangiocarcinoma - mortality Cholangiocarcinoma - surgery Circulating Tumor DNA - blood Cisplatin - administration & dosage Cisplatin - therapeutic use ctDNA Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Disease-Free Survival extrahepatic cholangiocarcinoma Female Gemcitabine gemcitabine plus cisplatin Humans Male Middle Aged Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - diagnosis Neoplasm, Residual Prognosis prognostic biomarker adjuvant capecitabine prognostic biomarker gemcitabine plus cisplatin extrahepatic cholangiocarcinoma ctDNA
ISSN:	0168-8278, 1600-0641, 1600-0641
Online Access:	Get full text
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