In vitro vs. in vivo tape stripping: Validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions

In vitro tape stripping on porcine ear skin and in vivo tape stripping on human forearm skin yield comparable results. Porcine ear skin is frequently used as a substitute for human skin in dermatological research and is especially useful for tape stripping experiments where the penetration of active...

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Vydané v:	European journal of pharmaceutics and biopharmaceutics Ročník 80; číslo 3; s. 604 - 614
Hlavní autori:	Klang, Victoria, Schwarz, Julia C., Lenobel, Barbara, Nadj, Martina, Auböck, Josef, Wolzt, Michael, Valenta, Claudia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Amsterdam Elsevier B.V 01.04.2012 Elsevier
Predmet:	Adolescent Adult Animals Biological and medical sciences Curcumin - administration & dosage Ear, External Emulsions - administration & dosage Female Fluorescein - administration & dosage Forearm General pharmacology Humans Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage Male Medical sciences Nanoemulsion Nanotechnology - methods Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porcine ears Skin - metabolism Skin Absorption - drug effects Skin penetration Sucrose - administration & dosage Sucrose - analogs & derivatives Sucrose stearate Surface Properties - drug effects Swine Tape stripping Young Adult SC Porcine ears Skin penetration TEWL NIR-densitometry Sucrose stearate Nanoemulsion Tape stripping Validation Evaluation Pharmaceutical technology Sucrose Stearate Adhesive tape In vitro Pig In vivo Vertebrata Mammalia Emulsion Penetration Animal Ear Skin Artiodactyla Ungulata
ISSN:	0939-6411, 1873-3441, 1873-3441
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