Age-related differences in appetitive trace conditioning and novel object recognition procedures

•Longitudinal study of middle age in the rat with matched younger control cohort.•Appetitive trace conditioning and novel object recognition tests of working memory.•Transient between-groups working memory impairments aged 12 compared with 2 months.•Object exploration reduced with age but working me...

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Vydáno v:Neurobiology of learning and memory Ročník 164; s. 107041
Hlavní autoři: Marshall, Hayley J., Pezze, Marie A., Fone, Kevin C.F., Cassaday, Helen J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.10.2019
Academic Press
Témata:
Animals
Appetitive Behavior - physiology
Conditioning, Operant - physiology
Corpus Striatum - metabolism
Dorsal striatum
HPLC-ED
Hydroxyindoleacetic Acid - metabolism
Male
Medial prefrontal cortex
Memory, Short-Term - physiology
Nucleus accumbens
Rat
Rats, Wistar
Recognition, Psychology - physiology
Serotonin - metabolism
Trace conditioning
Nucleus accumbens
Medial prefrontal cortex
Rat
Trace conditioning
Dorsal striatum
HPLC-ED
ISSN:1074-7427, 1095-9564, 1095-9564
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Shrnutí:•Longitudinal study of middle age in the rat with matched younger control cohort.•Appetitive trace conditioning and novel object recognition tests of working memory.•Transient between-groups working memory impairments aged 12 compared with 2 months.•Object exploration reduced with age but working memory recovered.•Object exploration and ITI nosepoking showed some correlation with 5-HIAA/5-HT. Appetitive trace conditioning (TC) was examined over 6 months in younger-adult (2–8 months) and middle-aged (12–18 months) male Wistar RccHan rats, to test for early age-related impairment in working memory. Novel object recognition (NOR) was included as a comparison task, to provide a positive control in the event that the expected impairment in TC was not demonstrated. The results showed that TC improved at both ages at the 2 s but not at the 10 s trace interval. There was, however, evidence for reduced improvement from one day to the next in the middle-aged cohort tested with the 2 s trace conditioned stimulus. Moreover, within the 10 s trace, responding progressively distributed later in the trace interval, in the younger-adult but not the middle-aged cohort. Middle-aged rats showed NOR discriminative impairment at a 24 h but not at a 10 min retention interval. Object exploration was overall reduced in middle-aged rats and further reduced longitudinally. At the end of the study, assessing neurochemistry by HPLC-ED showed reduced 5-HIAA/5-HT in the dorsal striatum of the middle-aged rats and some correlations between striatal 5-HIAA/5-HT and activity parameters. Overall the results suggest that, taken in isolation, age-related impairments may be overcome by experience. This recovery in performance was seen despite the drop in activity levels in older animals, which might be expected to contribute to cognitive decline.
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ISSN:1074-7427
1095-9564
1095-9564
DOI:10.1016/j.nlm.2019.107041