Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis

Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic study of AD with deeply sequenced RNA-sequencing samples using long (126-bp) paired-end reads. In addition to the comparis...

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Vydáno v:	Journal of investigative dermatology Ročník 139; číslo 7; s. 1480
Hlavní autoři:	Tsoi, Lam C, Rodriguez, Elke, Degenhardt, Frauke, Baurecht, Hansjörg, Wehkamp, Ulrike, Volks, Natalie, Szymczak, Silke, Swindell, William R, Sarkar, Mrinal K, Raja, Kalpana, Shao, Shuai, Patrick, Matthew, Gao, Yilin, Uppala, Ranjitha, Perez White, Bethany E, Getsios, Spiro, Harms, Paul W, Maverakis, Emanual, Elder, James T, Franke, Andre, Gudjonsson, Johann E, Weidinger, Stephan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2019
Témata:	Cohort Studies Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Gene Expression Profiling Humans Interleukin-13 - genetics Interleukin-13 - metabolism Interleukin-4 - metabolism Organ Specificity - genetics Psoriasis - genetics Psoriasis - immunology RNA - genetics RNA, Long Noncoding - genetics Sequence Analysis, RNA Signal Transduction Skin - metabolism Skin - pathology Th2 Cells - immunology Transcriptome
ISSN:	1523-1747, 1523-1747
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